MCP-5 suppresses osteoclast differentiation through Ccr5 upregulation
© 2024 Wiley Periodicals LLC..
Human monocyte chemoattractant protein-1 (MCP-1) in mice has two orthologs, MCP-1 and MCP-5. MCP-1, which is highly expressed in osteoclasts rather than in osteoclast precursor cells, is an important factor in osteoclast differentiation. However, the roles of MCP-5 in osteoclasts are completely unknown. In this study, contrary to MCP-1, MCP-5 was downregulated during receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast differentiation and was considered an inhibitory factor in osteoclast differentiation. The inhibitory role of MCP-5 in osteoclast differentiation was closely related to the increase in Ccr5 expression and the inhibition of IκB degradation by RANKL. Transgenic mice expressing MCP-5 controlled by Mx-1 promoter exhibited an increased bone mass because of a decrease in osteoclasts. This result strongly supported that MCP-5 negatively regulated osteoclast differentiation. MCP-5 also prevented severe bone loss caused by RANKL.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:239 |
---|---|
Enthalten in: |
Journal of cellular physiology - 239(2024), 2 vom: 15. Feb., Seite e31171 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Kim, Jung Ha [VerfasserIn] |
---|
Links: |
---|
Themen: |
CCR5 protein, mouse |
---|
Anmerkungen: |
Date Completed 16.02.2024 Date Revised 16.02.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1002/jcp.31171 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM367046520 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM367046520 | ||
003 | DE-627 | ||
005 | 20240216232727.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240114s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1002/jcp.31171 |2 doi | |
028 | 5 | 2 | |a pubmed24n1295.xml |
035 | |a (DE-627)NLM367046520 | ||
035 | |a (NLM)38214098 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Kim, Jung Ha |e verfasserin |4 aut | |
245 | 1 | 0 | |a MCP-5 suppresses osteoclast differentiation through Ccr5 upregulation |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 16.02.2024 | ||
500 | |a Date Revised 16.02.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2024 Wiley Periodicals LLC. | ||
520 | |a Human monocyte chemoattractant protein-1 (MCP-1) in mice has two orthologs, MCP-1 and MCP-5. MCP-1, which is highly expressed in osteoclasts rather than in osteoclast precursor cells, is an important factor in osteoclast differentiation. However, the roles of MCP-5 in osteoclasts are completely unknown. In this study, contrary to MCP-1, MCP-5 was downregulated during receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast differentiation and was considered an inhibitory factor in osteoclast differentiation. The inhibitory role of MCP-5 in osteoclast differentiation was closely related to the increase in Ccr5 expression and the inhibition of IκB degradation by RANKL. Transgenic mice expressing MCP-5 controlled by Mx-1 promoter exhibited an increased bone mass because of a decrease in osteoclasts. This result strongly supported that MCP-5 negatively regulated osteoclast differentiation. MCP-5 also prevented severe bone loss caused by RANKL | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Ccr5 | |
650 | 4 | |a JNK | |
650 | 4 | |a MCP-5 | |
650 | 4 | |a NF-κB | |
650 | 4 | |a osteoclast | |
650 | 7 | |a Membrane Glycoproteins |2 NLM | |
650 | 7 | |a NF-kappa B |2 NLM | |
650 | 7 | |a RANK Ligand |2 NLM | |
650 | 7 | |a Receptor Activator of Nuclear Factor-kappa B |2 NLM | |
650 | 7 | |a Monocyte Chemoattractant Proteins |2 NLM | |
650 | 7 | |a CCR5 protein, mouse |2 NLM | |
700 | 1 | |a Kim, Kabsun |e verfasserin |4 aut | |
700 | 1 | |a Kim, Inyoung |e verfasserin |4 aut | |
700 | 1 | |a Seong, Semun |e verfasserin |4 aut | |
700 | 1 | |a Koh, Jeong-Tae |e verfasserin |4 aut | |
700 | 1 | |a Kim, Nacksung |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of cellular physiology |d 1965 |g 239(2024), 2 vom: 15. Feb., Seite e31171 |w (DE-627)NLM000005304 |x 1097-4652 |7 nnns |
773 | 1 | 8 | |g volume:239 |g year:2024 |g number:2 |g day:15 |g month:02 |g pages:e31171 |
856 | 4 | 0 | |u http://dx.doi.org/10.1002/jcp.31171 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 239 |j 2024 |e 2 |b 15 |c 02 |h e31171 |