Causal effects of educational attainment on temporomandibular disorders and the mediating pathways : A Mendelian randomization study
© 2024 John Wiley & Sons Ltd..
BACKGROUND: As one of the most important indicators of socioeconomic status, educational attainment (EA) exhibits a strong association with temporomandibular disorders (TMDs). Despite this link, there is a lack of evidence regarding the causal role of EA in either facilitating or preventing TMDs.
OBJECTIVE: This study aimed to investigate the causal effect of education on TMDs and explore potential mediating pathways.
METHODS: Utilizing summary statistics from genome-wide association studies on years of schooling (N = 766 345) and TMDs (N = 211 023), we conducted Mendelian randomization (MR) to assess the overall effect of education. Additionally, a two-step MR approach was employed to evaluate 30 potential mediators and calculate the mediation proportions in the association. Comprehensive sensitivity analyses were used to verify the robustness, heterogeneity, and pleiotropy.
RESULTS: Univariable MR analyses revealed a causal effect of lower EA on an increased risk of TMDs (OR: 0.53, 95% CI: 0.43-0.66, p < .001). Five out of 30 modifiable factors were identified as causal mediators in the associations of EA with TMDs, including feeling nervous (mediation proportion: 11.6%), feeling tense (10.2%), depression (9.6%), feeling worry (7.6%) and daily smoking (8.9%). Meanwhile, no pleiotropy was detected in the analyses (p > .05).
CONCLUSION: Our findings supported that higher EA has a protective effect on the onset of TMDs, with partial mediation by psychological disorders and daily smoking. Interventions on these factors thus have the potential of substantially reducing the burden of TMDs attributed to low education.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
|---|---|
| Enthalten in: |
Journal of oral rehabilitation - 51(2024), 5 vom: 18. Apr., Seite 817-826 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chen, Xin [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Educational status |
|---|
| Anmerkungen: |
Date Completed 09.04.2024 Date Revised 26.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/joor.13654 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM36696173X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM36696173X | ||
| 003 | DE-627 | ||
| 005 | 20240427232033.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240114s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/joor.13654 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1390.xml |
| 035 | |a (DE-627)NLM36696173X | ||
| 035 | |a (NLM)38205584 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chen, Xin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Causal effects of educational attainment on temporomandibular disorders and the mediating pathways |b A Mendelian randomization study |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 09.04.2024 | ||
| 500 | |a Date Revised 26.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: As one of the most important indicators of socioeconomic status, educational attainment (EA) exhibits a strong association with temporomandibular disorders (TMDs). Despite this link, there is a lack of evidence regarding the causal role of EA in either facilitating or preventing TMDs | ||
| 520 | |a OBJECTIVE: This study aimed to investigate the causal effect of education on TMDs and explore potential mediating pathways | ||
| 520 | |a METHODS: Utilizing summary statistics from genome-wide association studies on years of schooling (N = 766 345) and TMDs (N = 211 023), we conducted Mendelian randomization (MR) to assess the overall effect of education. Additionally, a two-step MR approach was employed to evaluate 30 potential mediators and calculate the mediation proportions in the association. Comprehensive sensitivity analyses were used to verify the robustness, heterogeneity, and pleiotropy | ||
| 520 | |a RESULTS: Univariable MR analyses revealed a causal effect of lower EA on an increased risk of TMDs (OR: 0.53, 95% CI: 0.43-0.66, p < .001). Five out of 30 modifiable factors were identified as causal mediators in the associations of EA with TMDs, including feeling nervous (mediation proportion: 11.6%), feeling tense (10.2%), depression (9.6%), feeling worry (7.6%) and daily smoking (8.9%). Meanwhile, no pleiotropy was detected in the analyses (p > .05) | ||
| 520 | |a CONCLUSION: Our findings supported that higher EA has a protective effect on the onset of TMDs, with partial mediation by psychological disorders and daily smoking. Interventions on these factors thus have the potential of substantially reducing the burden of TMDs attributed to low education | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Mendelian randomization analysis | |
| 650 | 4 | |a educational status | |
| 650 | 4 | |a mediation analysis | |
| 650 | 4 | |a risk factors | |
| 650 | 4 | |a temporomandibular disorders | |
| 650 | 4 | |a temporomandibular joint disorders | |
| 700 | 1 | |a Cheng, Zheng |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Junyu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Qianyi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Zhibai |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Qianglin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of oral rehabilitation |d 1974 |g 51(2024), 5 vom: 18. Apr., Seite 817-826 |w (DE-627)NLM000367508 |x 1365-2842 |7 nnns |
| 773 | 1 | 8 | |g volume:51 |g year:2024 |g number:5 |g day:18 |g month:04 |g pages:817-826 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/joor.13654 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 51 |j 2024 |e 5 |b 18 |c 04 |h 817-826 | ||