Infectious complications following major heart surgery from the day of the surgery to hospital discharge
© 2024. The Author(s)..
BACKGROUND: At some point in their lives, many people will require major heart surgery (MHS). Patients are generally older adults with various risk factors for infection. However, the incidence of infection after MHS is poorly known, as reported infection data are frequently biased due to different factors like the surgical procedure, postoperative timing, and infectious syndromes or etiologic agents, among others. In addition, most patient data are retrospectively obtained.
PURPOSE AND METHODS: Data were prospectively collected regarding the incidence of all nosocomial infections produced from the time of surgery to hospital discharge in a cohort of 800 adults consecutively undergoing a MHS procedure.
RESULTS: During postoperative hospitalization, 124 of the 800 participants developed one or more infections (15.5%): during their ICU stay in 68 patients (54.8%), during their stay on the general ward post ICU in 50 (40.3%), and during their stay in both wards in 6 (4.8%). The most common infections were pneumonia (related or not to mechanical ventilation), surgical site and bloodstream. As etiological agents, 193 pathogens were isolated: mostly Gram-negative bacilli (54.4%), followed by Gram-positive bacteria (30%), viruses (4.6%) and fungi (1.5%). In our cohort, all-cause mortality was recorded in 33 participants (4.1%) and 9 infection-related deaths (1.1%) were produced. Among subjects who developed infections, overall mortality was 13.7% and in those who did not, this was only 2.3%.
CONCLUSION: Infection following MHS remains frequent and severe. Our data suggest that hospital-acquired infection studies should consider episodes of infection in all populations during their entire hospital stay and not only those related to specific clinical syndromes or acquired while the patient is in intensive care.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
BMC infectious diseases - 24(2024), 1 vom: 11. Jan., Seite 73 |
| Sprache: |
Englisch |
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| Links: |
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| Themen: |
Bloodstream infections |
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| Anmerkungen: |
Date Completed 12.01.2024 Date Revised 13.01.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12879-023-08972-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM366910159 |
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| 100 | 1 | |a Pérez-Granda, Maria Jesús |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Infectious complications following major heart surgery from the day of the surgery to hospital discharge |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 12.01.2024 | ||
| 500 | |a Date Revised 13.01.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a BACKGROUND: At some point in their lives, many people will require major heart surgery (MHS). Patients are generally older adults with various risk factors for infection. However, the incidence of infection after MHS is poorly known, as reported infection data are frequently biased due to different factors like the surgical procedure, postoperative timing, and infectious syndromes or etiologic agents, among others. In addition, most patient data are retrospectively obtained | ||
| 520 | |a PURPOSE AND METHODS: Data were prospectively collected regarding the incidence of all nosocomial infections produced from the time of surgery to hospital discharge in a cohort of 800 adults consecutively undergoing a MHS procedure | ||
| 520 | |a RESULTS: During postoperative hospitalization, 124 of the 800 participants developed one or more infections (15.5%): during their ICU stay in 68 patients (54.8%), during their stay on the general ward post ICU in 50 (40.3%), and during their stay in both wards in 6 (4.8%). The most common infections were pneumonia (related or not to mechanical ventilation), surgical site and bloodstream. As etiological agents, 193 pathogens were isolated: mostly Gram-negative bacilli (54.4%), followed by Gram-positive bacteria (30%), viruses (4.6%) and fungi (1.5%). In our cohort, all-cause mortality was recorded in 33 participants (4.1%) and 9 infection-related deaths (1.1%) were produced. Among subjects who developed infections, overall mortality was 13.7% and in those who did not, this was only 2.3% | ||
| 520 | |a CONCLUSION: Infection following MHS remains frequent and severe. Our data suggest that hospital-acquired infection studies should consider episodes of infection in all populations during their entire hospital stay and not only those related to specific clinical syndromes or acquired while the patient is in intensive care | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bloodstream infections | |
| 650 | 4 | |a Major heart surgery | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Nosocomial infections | |
| 650 | 4 | |a Pneumonia | |
| 650 | 4 | |a Postoperative infections | |
| 650 | 4 | |a Surgical site infections | |
| 650 | 4 | |a Ventilator associated pneumonia | |
| 700 | 1 | |a Barrio, José María |e verfasserin |4 aut | |
| 700 | 1 | |a Cuerpo, Gregorio |e verfasserin |4 aut | |
| 700 | 1 | |a Valerio, Maricela |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Hortal, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Pinto, Angel González |e verfasserin |4 aut | |
| 700 | 1 | |a Bouza, Emilio |e verfasserin |4 aut | |
| 700 | 0 | |a Cardiovascular Infection Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Quintana, Begoña |e investigator |4 oth | |
| 700 | 1 | |a Sánchez, Alejandro Garrido |e investigator |4 oth | |
| 700 | 1 | |a Barranco, Mónica |e investigator |4 oth | |
| 700 | 1 | |a Perez, Eduardo Sánchez |e investigator |4 oth | |
| 700 | 1 | |a Moraga, Francisco |e investigator |4 oth | |
| 700 | 1 | |a López, Alba |e investigator |4 oth | |
| 700 | 1 | |a Bono, Patricia |e investigator |4 oth | |
| 700 | 1 | |a López, Ignacio Fernández |e investigator |4 oth | |
| 700 | 1 | |a Bernal, Guillermo Rodríguez |e investigator |4 oth | |
| 700 | 1 | |a Novoa, Enma |e investigator |4 oth | |
| 700 | 1 | |a Abella, Roberto Hugo Rodríguez |e investigator |4 oth | |
| 700 | 1 | |a Ruiz, Manolo |e investigator |4 oth | |
| 700 | 1 | |a Pedraz, Alvaro |e investigator |4 oth | |
| 700 | 1 | |a Diaz, Diego Monzón |e investigator |4 oth | |
| 700 | 1 | |a Fortuny, Ramón |e investigator |4 oth | |
| 700 | 1 | |a Lega, Javier Rodríguez |e investigator |4 oth | |
| 700 | 1 | |a Gallardo, Maria Yolanda Villa |e investigator |4 oth | |
| 700 | 1 | |a Calvo, Laura Diaz |e investigator |4 oth | |
| 700 | 1 | |a Gallego, Sara Solís |e investigator |4 oth | |
| 700 | 1 | |a Mere, Carmen Garcia |e investigator |4 oth | |
| 700 | 1 | |a Tomás, Alvaro Alvarez |e investigator |4 oth | |
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