Validation of Echocardiographic Measurements in Patients with Pulmonary Embolism in the RIETE Registry
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ )..
Background In acute pulmonary embolism (PE), echocardiographic identification of right ventricular (RV) dysfunction will inform prognostication and clinical decision-making. Registro Informatizado Enfermedad TromboEmbolica (RIETE) is the world's largest registry of patients with objectively confirmed PE. The reliability of site-reported RV echocardiographic measurements is unknown. We aimed to validate site-reported key RV echocardiographic measurements in the RIETE registry. Methods Fifty-one randomly chosen patients in RIETE who had transthoracic echocardiogram (TTE) performed for acute PE were included. TTEs were de-identified and analyzed by a core laboratory of two independent observers blinded to site-reported data. To investigate reliability, intraclass correlation coefficients (ICCs) and Bland-Altman plots between the two observers, and between an average of the two observers and the RIETE site-reported data were obtained. Results Core laboratory interobserver variations were very limited with correlation coefficients >0.8 for all TTE parameters. Agreement was substantial between core laboratory observers and site-reported data for key parameters including tricuspid annular plane systolic excursion (ICC 0.728; 95% confidence interval [CI], 0.594-0.862) and pulmonary arterial systolic pressure (ICC 0.726; 95% CI, 0.601-0.852). Agreement on right-to-left ventricular diameter ratio (ICC 0.739; 95% CI, 0.443-1.000) was validated, although missing data limited the precision of the estimates. Bland-Altman plots showed differences close to zero. Conclusion We showed substantial reliability of key RV site-reported measurements in the RIETE registry. Ascertaining the validity of such data adds confidence and reliability for subsequent investigations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
TH open : companion journal to thrombosis and haemostasis - 8(2024), 1 vom: 03. Jan., Seite e1-e8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lyhne, Mads Dam [VerfasserIn] |
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| Links: |
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| Themen: |
Echocardiography |
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| Anmerkungen: |
Date Revised 11.01.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1055/s-0043-1777765 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM366876104 |
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| 520 | |a The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ). | ||
| 520 | |a Background In acute pulmonary embolism (PE), echocardiographic identification of right ventricular (RV) dysfunction will inform prognostication and clinical decision-making. Registro Informatizado Enfermedad TromboEmbolica (RIETE) is the world's largest registry of patients with objectively confirmed PE. The reliability of site-reported RV echocardiographic measurements is unknown. We aimed to validate site-reported key RV echocardiographic measurements in the RIETE registry. Methods Fifty-one randomly chosen patients in RIETE who had transthoracic echocardiogram (TTE) performed for acute PE were included. TTEs were de-identified and analyzed by a core laboratory of two independent observers blinded to site-reported data. To investigate reliability, intraclass correlation coefficients (ICCs) and Bland-Altman plots between the two observers, and between an average of the two observers and the RIETE site-reported data were obtained. Results Core laboratory interobserver variations were very limited with correlation coefficients >0.8 for all TTE parameters. Agreement was substantial between core laboratory observers and site-reported data for key parameters including tricuspid annular plane systolic excursion (ICC 0.728; 95% confidence interval [CI], 0.594-0.862) and pulmonary arterial systolic pressure (ICC 0.726; 95% CI, 0.601-0.852). Agreement on right-to-left ventricular diameter ratio (ICC 0.739; 95% CI, 0.443-1.000) was validated, although missing data limited the precision of the estimates. Bland-Altman plots showed differences close to zero. Conclusion We showed substantial reliability of key RV site-reported measurements in the RIETE registry. Ascertaining the validity of such data adds confidence and reliability for subsequent investigations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a echocardiography | |
| 650 | 4 | |a pulmonary circulation | |
| 650 | 4 | |a reliability | |
| 650 | 4 | |a right ventricular function | |
| 650 | 4 | |a validity | |
| 700 | 1 | |a Bikdeli, Behnood |e verfasserin |4 aut | |
| 700 | 1 | |a Dudzinski, David M |e verfasserin |4 aut | |
| 700 | 1 | |a Muriel-García, Alfonso |e verfasserin |4 aut | |
| 700 | 1 | |a Kabrhel, Christopher |e verfasserin |4 aut | |
| 700 | 1 | |a Sancho-Bueso, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-David, Esther |e verfasserin |4 aut | |
| 700 | 1 | |a Lobo, José Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Alonso-Gómez, Ángel |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez, David |e verfasserin |4 aut | |
| 700 | 1 | |a Monreal, Manuel |e verfasserin |4 aut | |
| 700 | 0 | |a RIETE Investigators |e verfasserin |4 aut | |
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