A bis-boron boramino acid PET tracer for brain tumor diagnosis
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
PURPOSE: Boramino acids are a class of amino acid biomimics that replace the carboxylate group with trifluoroborate and can achieve the 18F-labeled positron emission tomography (PET) and boron neutron capture therapy (BNCT) with identical chemical structure.
METHODS: This study reports a trifluoroborate-derived boronophenylalanine (BBPA), a derived boronophenylalanine (BPA) for BNCT, as a promising PET tracer for tumor imaging.
RESULTS: Competition inhibition assays in cancer cells suggested the cell accumulation of [18F]BBPA is through large neutral amino acid transporter type-1 (LAT-1). Of note, [18F]BBPA is a pan-cancer probe that shows notable tumor uptake in B16-F10 tumor-bearing mice. In the patients with gliomas and metastatic brain tumors, [18F]BBPA-PET shows good tumor uptake and notable tumor-to-normal brain ratio (T/N ratio, 18.7 ± 5.5, n = 11), higher than common amino acid PET tracers. The [18F]BBPA-PET quantitative parameters exhibited no difference in diverse contrast-enhanced status (P = 0.115-0.687) suggesting the [18F]BBPA uptake was independent from MRI contrast-enhancement.
CONCLUSION: This study outlines a clinical trial with [18F]BBPA to achieve higher tumor-specific accumulation for PET, provides a potential technique for brain tumor diagnosis, and might facilitate the BNCT of brain tumors.
| Errataetall: |
ErratumIn: Eur J Nucl Med Mol Imaging. 2024 Mar 22;:. - PMID 38517519 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
European journal of nuclear medicine and molecular imaging - 51(2024), 6 vom: 08. Apr., Seite 1703-1712 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Zhu [VerfasserIn] |
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| Links: |
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| Themen: |
Boramino acid |
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| Anmerkungen: |
Date Completed 24.04.2024 Date Revised 25.04.2024 published: Print-Electronic ErratumIn: Eur J Nucl Med Mol Imaging. 2024 Mar 22;:. - PMID 38517519 Citation Status MEDLINE |
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| doi: |
10.1007/s00259-024-06600-5 |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 2 | |a A bis-boron boramino acid PET tracer for brain tumor diagnosis |
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| 500 | |a ErratumIn: Eur J Nucl Med Mol Imaging. 2024 Mar 22;:. - PMID 38517519 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a PURPOSE: Boramino acids are a class of amino acid biomimics that replace the carboxylate group with trifluoroborate and can achieve the 18F-labeled positron emission tomography (PET) and boron neutron capture therapy (BNCT) with identical chemical structure | ||
| 520 | |a METHODS: This study reports a trifluoroborate-derived boronophenylalanine (BBPA), a derived boronophenylalanine (BPA) for BNCT, as a promising PET tracer for tumor imaging | ||
| 520 | |a RESULTS: Competition inhibition assays in cancer cells suggested the cell accumulation of [18F]BBPA is through large neutral amino acid transporter type-1 (LAT-1). Of note, [18F]BBPA is a pan-cancer probe that shows notable tumor uptake in B16-F10 tumor-bearing mice. In the patients with gliomas and metastatic brain tumors, [18F]BBPA-PET shows good tumor uptake and notable tumor-to-normal brain ratio (T/N ratio, 18.7 ± 5.5, n = 11), higher than common amino acid PET tracers. The [18F]BBPA-PET quantitative parameters exhibited no difference in diverse contrast-enhanced status (P = 0.115-0.687) suggesting the [18F]BBPA uptake was independent from MRI contrast-enhancement | ||
| 520 | |a CONCLUSION: This study outlines a clinical trial with [18F]BBPA to achieve higher tumor-specific accumulation for PET, provides a potential technique for brain tumor diagnosis, and might facilitate the BNCT of brain tumors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Boramino acid | |
| 650 | 4 | |a Brain tumor | |
| 650 | 4 | |a Positron emission tomography | |
| 650 | 7 | |a Boron Compounds |2 NLM | |
| 650 | 7 | |a Radioactive Tracers |2 NLM | |
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| 700 | 1 | |a Chen, Junyi |e verfasserin |4 aut | |
| 700 | 1 | |a Kong, Ziren |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Yixin |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Mengxin |e verfasserin |4 aut | |
| 700 | 1 | |a Mu, Bo-Shuai |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Wenbin |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Zhi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zhibo |e verfasserin |4 aut | |
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