Matrix Gla protein polymorphism rs1800802 is associated with atheroma plaque progression and with cardiovascular events in a chronic kidney disease cohort
© The Author(s) 2023. Published by Oxford University Press on behalf of the ERA..
Background: Chronic kidney disease (CKD) is associated with increased atherosclerotic burden and higher risk for cardiovascular events (CVE). Atherosclerosis has a significant genetic component and, in CKD, it is influenced by mineral metabolism alterations. Therefore, genetic modifications of mineral metabolism-related proteins could affect atherosclerosis in CKD patients. In the present study we investigated the role of single nucleotide polymorphisms (SNPs) of the matrix gamma-carboxy glutamic acid protein (MGP) on atherosclerosis progression and CVE in a CKD cohort.
Methods: A total of 2187 CKD patients from the Observatorio Nacional de Aterosclerosis en Nefrologia (NEFRONA) study were genotyped for SNPs present in the matrix gamma-carboxy glutamic acid (Gla) protein (MGP) gene. Atheromatosis was detected by vascular ultrasound. Progression of atheromatosis, defined as an increase in territories with plaque, was assessed after 24 months. Patients were followed for 48 months for CVE. Association of SNPs with plaque progression was assessed by logistic regression and their capacity to predict CVE by Cox regression.
Results: Three SNPs of the MGP gene were analyzed. No association of the rs4236 or the rs1800801 SNPs was detected with any of the outcomes. However, patients homozygotes for the minor allele of the rs1800802 SNP showed higher adjusted risk for plaque progression [odds ratio 2.3 (95% confidence interval 1.06-4.9)] and higher risk of suffering a CVE [hazard ratio 2.16 (95% confidence interval 1.13-4.12)] compared with the rest of genotypes. No association of the SNP with total or dp-ucMGP levels was found in a subsample.
Conclusions: The rs1800802 polymorphism of MGP is associated with plaque progression and CVE in CKD patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
|---|---|
| Enthalten in: |
Clinical kidney journal - 17(2024), 1 vom: 28. Jan., Seite sfad257 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
Atherosclerosis progression |
|---|
| Anmerkungen: |
Date Revised 09.01.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1093/ckj/sfad257 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM366775057 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM366775057 | ||
| 003 | DE-627 | ||
| 005 | 20240114233137.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240114s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/ckj/sfad257 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1253.xml |
| 035 | |a (DE-627)NLM366775057 | ||
| 035 | |a (NLM)38186884 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Cambray, Serafí |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Matrix Gla protein polymorphism rs1800802 is associated with atheroma plaque progression and with cardiovascular events in a chronic kidney disease cohort |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 09.01.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of the ERA. | ||
| 520 | |a Background: Chronic kidney disease (CKD) is associated with increased atherosclerotic burden and higher risk for cardiovascular events (CVE). Atherosclerosis has a significant genetic component and, in CKD, it is influenced by mineral metabolism alterations. Therefore, genetic modifications of mineral metabolism-related proteins could affect atherosclerosis in CKD patients. In the present study we investigated the role of single nucleotide polymorphisms (SNPs) of the matrix gamma-carboxy glutamic acid protein (MGP) on atherosclerosis progression and CVE in a CKD cohort | ||
| 520 | |a Methods: A total of 2187 CKD patients from the Observatorio Nacional de Aterosclerosis en Nefrologia (NEFRONA) study were genotyped for SNPs present in the matrix gamma-carboxy glutamic acid (Gla) protein (MGP) gene. Atheromatosis was detected by vascular ultrasound. Progression of atheromatosis, defined as an increase in territories with plaque, was assessed after 24 months. Patients were followed for 48 months for CVE. Association of SNPs with plaque progression was assessed by logistic regression and their capacity to predict CVE by Cox regression | ||
| 520 | |a Results: Three SNPs of the MGP gene were analyzed. No association of the rs4236 or the rs1800801 SNPs was detected with any of the outcomes. However, patients homozygotes for the minor allele of the rs1800802 SNP showed higher adjusted risk for plaque progression [odds ratio 2.3 (95% confidence interval 1.06-4.9)] and higher risk of suffering a CVE [hazard ratio 2.16 (95% confidence interval 1.13-4.12)] compared with the rest of genotypes. No association of the SNP with total or dp-ucMGP levels was found in a subsample | ||
| 520 | |a Conclusions: The rs1800802 polymorphism of MGP is associated with plaque progression and CVE in CKD patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a atherosclerosis progression | |
| 650 | 4 | |a cardiovascular events | |
| 650 | 4 | |a chronic kidney disease | |
| 650 | 4 | |a matrix gamma-carboxy glutamic acid (Gla) protein | |
| 650 | 4 | |a polymorphisms | |
| 700 | 1 | |a Bermúdez-López, Marcelino |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia-Carrasco, Alicia |e verfasserin |4 aut | |
| 700 | 1 | |a Valdivielso, Jose M |e verfasserin |4 aut | |
| 700 | 0 | |a NEFRONA investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Aladrén Regidor, Mª José |e investigator |4 oth | |
| 700 | 1 | |a Almirall, Jaume |e investigator |4 oth | |
| 700 | 1 | |a Ponz, Esther |e investigator |4 oth | |
| 700 | 1 | |a Coloma, Jesús Arteaga |e investigator |4 oth | |
| 700 | 1 | |a Rubio, Bajo |e investigator |4 oth | |
| 700 | 1 | |a Aladrén Regidor, Mª José |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez, Belart |e investigator |4 oth | |
| 700 | 1 | |a Gascón, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Sanjuan, Jordi Bover |e investigator |4 oth | |
| 700 | 1 | |a Artero, Josep Bronsoms |e investigator |4 oth | |
| 700 | 1 | |a Cabezuelo Romero, Juan B |e investigator |4 oth | |
| 700 | 1 | |a Cases, Muray |e investigator |4 oth | |
| 700 | 1 | |a Calviño Varela, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Acevedo, Pilar Caro |e investigator |4 oth | |
| 700 | 1 | |a Bassa, Jordi Carreras |e investigator |4 oth | |
| 700 | 1 | |a Amenós, Aleix Cases |e investigator |4 oth | |
| 700 | 1 | |a Jiménez, Elisabet Massó |e investigator |4 oth | |
| 700 | 1 | |a López, Rosario Moreno |e investigator |4 oth | |
| 700 | 1 | |a Guldris, Secundino Cigarrán |e investigator |4 oth | |
| 700 | 1 | |a Prieto, Saray López |e investigator |4 oth | |
| 700 | 1 | |a Mongay, Lourdes Comas |e investigator |4 oth | |
| 700 | 1 | |a Comerma, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Compte Jové, Mª Teresa |e investigator |4 oth | |
| 700 | 1 | |a Izquierdo, Marta Cuberes |e investigator |4 oth | |
| 700 | 1 | |a de Álvaro, Fernando |e investigator |4 oth | |
| 700 | 1 | |a Hevia Ojanguren, Covadonga |e investigator |4 oth | |
| 700 | 1 | |a de Arriba de la Fuente, Gabriel |e investigator |4 oth | |
| 700 | 1 | |a Del Pino Y Pino, Mª Dolores |e investigator |4 oth | |
| 700 | 1 | |a Diaz-Tejeiro Izquierdo, Rafael |e investigator |4 oth | |
| 700 | 1 | |a Dotori, Marta |e investigator |4 oth | |
| 700 | 1 | |a Duarte, Verónica |e investigator |4 oth | |
| 700 | 1 | |a Estupiñan Torres, Sara |e investigator |4 oth | |
| 700 | 1 | |a Fernández Reyes, Mª José |e investigator |4 oth | |
| 700 | 1 | |a Fernández Rodríguez, Mª Loreto |e investigator |4 oth | |
| 700 | 1 | |a Fernández, Guillermina |e investigator |4 oth | |
| 700 | 1 | |a Galán Serrano, Antonio |e investigator |4 oth | |
| 700 | 1 | |a García Cantón, Cesar |e investigator |4 oth | |
| 700 | 1 | |a García Herrera, Antonio L |e investigator |4 oth | |
| 700 | 1 | |a García Mena, Mercedes |e investigator |4 oth | |
| 700 | 1 | |a Gil Sacaluga, Luis |e investigator |4 oth | |
| 700 | 1 | |a Górriz, José Luis |e investigator |4 oth | |
| 700 | 1 | |a Huarte Loza, Emma |e investigator |4 oth | |
| 700 | 1 | |a Lerma, José Luis |e investigator |4 oth | |
| 700 | 1 | |a Liebana Cañada, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Marín Álvarez, Jesús Pedro |e investigator |4 oth | |
| 700 | 1 | |a Martín Alemany, Nàdia |e investigator |4 oth | |
| 700 | 1 | |a Martín García, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Martínez Castelao, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Martínez Villaescusa, María |e investigator |4 oth | |
| 700 | 1 | |a Martínez, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Moina Eguren, Iñigo |e investigator |4 oth | |
| 700 | 1 | |a Moreno Los Huertos, Silvia |e investigator |4 oth | |
| 700 | 1 | |a Mouzo Mirco, Ricardo |e investigator |4 oth | |
| 700 | 1 | |a Munar Vila, Antonia |e investigator |4 oth | |
| 700 | 1 | |a Muñoz Díaz, Ana Beatriz |e investigator |4 oth | |
| 700 | 1 | |a Navarro González, Juan F |e investigator |4 oth | |
| 700 | 1 | |a Nieto, Javier |e investigator |4 oth | |
| 700 | 1 | |a Carreño, Agustín |e investigator |4 oth | |
| 700 | 1 | |a Novoa Fernández, Enrique |e investigator |4 oth | |
| 700 | 1 | |a Ortiz, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Paraíso, Vicente |e investigator |4 oth | |
| 700 | 1 | |a Pérez Fontán, Miguel |e investigator |4 oth | |
| 700 | 1 | |a Peris Domingo, Ana |e investigator |4 oth | |
| 700 | 1 | |a Piñera Haces, Celestino |e investigator |4 oth | |
| 700 | 1 | |a Prados Garrido, Mª Dolores |e investigator |4 oth | |
| 700 | 1 | |a Prieto Velasco, Mario |e investigator |4 oth | |
| 700 | 1 | |a Puig Marí, Carmina |e investigator |4 oth | |
| 700 | 1 | |a Rivera Gorrín, Maite |e investigator |4 oth | |
| 700 | 1 | |a Rubio, Esther |e investigator |4 oth | |
| 700 | 1 | |a Ruiz, Pilar |e investigator |4 oth | |
| 700 | 1 | |a Salgueira Lazo, Mercedes |e investigator |4 oth | |
| 700 | 1 | |a Martínez Puerto, Ana Isabel |e investigator |4 oth | |
| 700 | 1 | |a Sánchez Tomero, José Antonio |e investigator |4 oth | |
| 700 | 1 | |a Sánchez, José Emilio |e investigator |4 oth | |
| 700 | 1 | |a Lorman, Ramon Sans |e investigator |4 oth | |
| 700 | 1 | |a Saracho, Ramon |e investigator |4 oth | |
| 700 | 1 | |a Sarrias, Maria |e investigator |4 oth | |
| 700 | 1 | |a Serón, Daniel |e investigator |4 oth | |
| 700 | 1 | |a Soler, María José |e investigator |4 oth | |
| 700 | 1 | |a Barrios, Clara |e investigator |4 oth | |
| 700 | 1 | |a Sousa, Fernando |e investigator |4 oth | |
| 700 | 1 | |a Toran, Daniel |e investigator |4 oth | |
| 700 | 1 | |a Molina, Fernando Tornero |e investigator |4 oth | |
| 700 | 1 | |a Carrasco, José Javier Usón |e investigator |4 oth | |
| 700 | 1 | |a Cortes, Ildefonso Valera |e investigator |4 oth | |
| 700 | 1 | |a Vilaprinyo Del Perugia, Mª Merce |e investigator |4 oth | |
| 700 | 1 | |a Virto Ruiz, Rafael C |e investigator |4 oth | |
| 700 | 1 | |a GilGil Área Básica Sanitaria de Arán, Inés |e investigator |4 oth | |
| 700 | 1 | |a Toro, Jose Mª Fernández |e investigator |4 oth | |
| 700 | 1 | |a Ibáñez, Juan Antonio Divisón Garrote Centro de Salud de Casas |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical kidney journal |d 2012 |g 17(2024), 1 vom: 28. Jan., Seite sfad257 |w (DE-627)NLM219739579 |x 2048-8505 |7 nnns |
| 773 | 1 | 8 | |g volume:17 |g year:2024 |g number:1 |g day:28 |g month:01 |g pages:sfad257 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/ckj/sfad257 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 17 |j 2024 |e 1 |b 28 |c 01 |h sfad257 | ||