Hyperferritinemia as a factor associated with poor prognosis in COVID-19 patients

Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to  assess  the  relationship  between  the  severity of Covid-19 and different clinical and laboratory parameters. A total number of 466 Arabs have willingly joined this prospective cohort. Out of the total number, 297 subjects (63.7%) had negative COVID-19 tests, and thus, they were recruited as controls, while 169 subjects (36.3%) who tested positive for COVID-19 were enrolled as cases. Out of the total number of COVID-19 patients, 127 (75.15%) presented with mild symptoms, and 42 (24.85%) had severe symptoms. The age range for the participants was 20 to 82 years. Compared with controls, the severity of the disease was associated with significantly high ferritin levels (P < 0.001). The severity of the disease was also associated with a significant increase in C-reactive protein (P < 0.001), D-dimer (P < 0.001), white blood cell count (WBC) (P < 0.01), IgM (P < 0.001), and Granulocytes (P < 0.01). In addition, severe COVID-19 symptoms in the current study were associated with a significant decrease in lymphocytes (P < 0.01). There was a four-fold increase in serum ferritin levels in COVID-19 patients presented with severe symptoms upon admission. The former was associated with significantly high levels of CRP and D-dimer. Thus, hyperferritinemia, together with high CRP and D-dimer concentrations, may serve as reliable predictors for disease severity and poor prognosis in Arabs with COVID-19.

Medienart:

Artikel

Erscheinungsjahr:

2024

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - volume:73

Enthalten in:

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti - 73(2024), 1 vom: 07., Seite 223-232

Sprache:

Englisch

Weiterer Titel:

Hyperferitinemie jako faktor spojený se špatnou prognózou u pacientů s COVID-19

Beteiligte Personen:

Al-Dulaimi, Nuhad Mohammed [VerfasserIn]
Mohammed, Mahmood Jassim [VerfasserIn]
Mutlk, Saad T [VerfasserIn]
Al-Rawi, Khalid F [VerfasserIn]
Ali, Hameed Hussein [VerfasserIn]
Aldahham, Bilal J M [VerfasserIn]
Al-Ani, Faisal [VerfasserIn]
Al-Ani, Osamah [VerfasserIn]
Hamed, Yaqout A [VerfasserIn]
Ali, Aus T [VerfasserIn]

Themen:

9007-73-2
COVID-19
Ferritin
Ferritins
Journal Article
Mild symptoms
Poor prognosis
Severe symptoms

Anmerkungen:

Date Completed 09.01.2024

Date Revised 09.01.2024

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM366762583