Exploring the in vivo anti-cancer potential of Neosetophomone B in leukemic cells using a zebrafish xenograft model
Copyright © 2024 Elsevier Inc. All rights reserved..
Neosetophomone B (NSP-B) is a unique meroterpenoid fungal secondary metabolite that has previously demonstrated promising anti-cancer properties against various cancer cell lines in vitro. However, its in vivo anti-cancer potential remaines unexplored. To fill this gap in our knowledge, we tested NSP-B's in vivo anti-cancer activity using a zebrafish model, an organism that has gained significant traction in biomedical research due to its genetic similarities with humans and its transparent nature, allowing real-time tumor growth observation. For our experiments, we employed the K562-injected zebrafish xenograft model. Upon treating these zebrafish with NSP-B, we observed a marked reduction in the size and number of tumor xenografts. Delving deeper, our analyses indicated that NSP-B curtailed tumor growth and proliferation of leukemic grafted xenograft within the zebrafish. These results show that NSP-B possesses potent in vivo anti-cancer properties, making it a potential novel therapeutic agent for addressing hematological malignancies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:435 |
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| Enthalten in: |
Experimental cell research - 435(2024), 1 vom: 01. Jan., Seite 113907 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kuttikrishnan, Shilpa [VerfasserIn] |
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| Links: |
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| Themen: |
Cell proliferation |
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| Anmerkungen: |
Date Completed 29.01.2024 Date Revised 29.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.yexcr.2023.113907 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Neosetophomone B (NSP-B) is a unique meroterpenoid fungal secondary metabolite that has previously demonstrated promising anti-cancer properties against various cancer cell lines in vitro. However, its in vivo anti-cancer potential remaines unexplored. To fill this gap in our knowledge, we tested NSP-B's in vivo anti-cancer activity using a zebrafish model, an organism that has gained significant traction in biomedical research due to its genetic similarities with humans and its transparent nature, allowing real-time tumor growth observation. For our experiments, we employed the K562-injected zebrafish xenograft model. Upon treating these zebrafish with NSP-B, we observed a marked reduction in the size and number of tumor xenografts. Delving deeper, our analyses indicated that NSP-B curtailed tumor growth and proliferation of leukemic grafted xenograft within the zebrafish. These results show that NSP-B possesses potent in vivo anti-cancer properties, making it a potential novel therapeutic agent for addressing hematological malignancies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cell proliferation | |
| 650 | 4 | |a Fungal secondary metabolites | |
| 650 | 4 | |a Leukemia | |
| 650 | 4 | |a Neosetophomone B | |
| 650 | 4 | |a Xenograft model | |
| 650 | 4 | |a Zebrafish | |
| 700 | 1 | |a Hasan, Maram |e verfasserin |4 aut | |
| 700 | 1 | |a Prabhu, Kirti S |e verfasserin |4 aut | |
| 700 | 1 | |a El-Elimat, Tamam |e verfasserin |4 aut | |
| 700 | 1 | |a Oberlies, Nicholas H |e verfasserin |4 aut | |
| 700 | 1 | |a Pearce, Cedric J |e verfasserin |4 aut | |
| 700 | 1 | |a Alali, Feras Q |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmad, Aamir |e verfasserin |4 aut | |
| 700 | 1 | |a Pourkarimi, Ehsan |e verfasserin |4 aut | |
| 700 | 1 | |a Bhat, Ajaz A |e verfasserin |4 aut | |
| 700 | 1 | |a Yalcin, Huseyin C |e verfasserin |4 aut | |
| 700 | 1 | |a Uddin, Shahab |e verfasserin |4 aut | |
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