The 4th NextGen therapies of SJIA and MAS, part 4 : it is time for IL-18 based trials in systemic juvenile idiopathic arthritis?
© 2023. The Author(s)..
Since IL-18 has recently emerged as a biomarker associated with refractory disease course in SJIA, the focus of the discussion was the feasibility of the biomarker-driven drug development to SJIA. Overall, there was broad agreement on the conclusion that IL-18 is a uniquely specific biomarker for many of the subsets of SJIA most in need of new therapies, and it may define a class of diseases mediated by IL-18 excess. The consensus was that leveraging IL-18 remains our most promising "lead" for use in refractory SJIA as it may mechanistically explain the disease pathophysiology and lead to more targeted therapies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Pediatric rheumatology online journal - 21(2024), Suppl 1 vom: 05. Jan., Seite 79 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Canna, Scott W [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarker driven trials |
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| Anmerkungen: |
Date Completed 08.01.2024 Date Revised 03.02.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12969-023-00867-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366736744 |
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| 245 | 1 | 4 | |a The 4th NextGen therapies of SJIA and MAS, part 4 |b it is time for IL-18 based trials in systemic juvenile idiopathic arthritis? |
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| 500 | |a Date Revised 03.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a Since IL-18 has recently emerged as a biomarker associated with refractory disease course in SJIA, the focus of the discussion was the feasibility of the biomarker-driven drug development to SJIA. Overall, there was broad agreement on the conclusion that IL-18 is a uniquely specific biomarker for many of the subsets of SJIA most in need of new therapies, and it may define a class of diseases mediated by IL-18 excess. The consensus was that leveraging IL-18 remains our most promising "lead" for use in refractory SJIA as it may mechanistically explain the disease pathophysiology and lead to more targeted therapies | ||
| 650 | 4 | |a Journal Article | |
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