Polyvinylpyrrolidone/chitosan-loaded dihydromyricetin-based nanofiber membrane promotes diabetic wound healing by anti-inflammatory and regulating autophagy-associated protein expression
Copyright © 2024 Elsevier B.V. All rights reserved..
The healing of wounds in diabetics is commonly delayed by recurring infections and persistent inflammation at the wound site. For this reason, we conducted a study using the electrospinning technique to create nanofiber membranes consisting of polyvinylpyrrolidone/chitosan (PVP/CS) and incorporated dihydromyricetin (DHM) into them. Infrared Fourier transform spectroscopy and scanning electron microscopy were used to analyze the nanofiber membrane. Experimental results in vitro have shown that PVP/CS/DHM has exceptional properties such as hydrophilicity, porosity, water vapor transport rate, antioxidant capacity, and antibacterial activity. Moreover, our study has demonstrated that the application of PVP/CS/DHM can significantly improve wound healing in diabetic mice. After an 18-day treatment period, a remarkable wound closure rate of 88.63 ± 1.37 % was achieved. The in vivo experiments revealed that PVP/CS/DHM can promote diabetic wound healing by suppressing the activation of TLR4/MyD88/NF-κB signaling pathway and enhancing autophagy-related protein as well as CD31 and HIF-1α expression in skin tissues. This study showed that PVP/CS/DHM is a promising wound dressing.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:259 |
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Enthalten in: |
International journal of biological macromolecules - 259(2024), Pt 1 vom: 12. Feb., Seite 129160 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Liu, Xinglong [VerfasserIn] |
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Links: |
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Themen: |
9012-76-4 |
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Anmerkungen: |
Date Completed 22.02.2024 Date Revised 22.02.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.ijbiomac.2023.129160 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM366725246 |
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520 | |a The healing of wounds in diabetics is commonly delayed by recurring infections and persistent inflammation at the wound site. For this reason, we conducted a study using the electrospinning technique to create nanofiber membranes consisting of polyvinylpyrrolidone/chitosan (PVP/CS) and incorporated dihydromyricetin (DHM) into them. Infrared Fourier transform spectroscopy and scanning electron microscopy were used to analyze the nanofiber membrane. Experimental results in vitro have shown that PVP/CS/DHM has exceptional properties such as hydrophilicity, porosity, water vapor transport rate, antioxidant capacity, and antibacterial activity. Moreover, our study has demonstrated that the application of PVP/CS/DHM can significantly improve wound healing in diabetic mice. After an 18-day treatment period, a remarkable wound closure rate of 88.63 ± 1.37 % was achieved. The in vivo experiments revealed that PVP/CS/DHM can promote diabetic wound healing by suppressing the activation of TLR4/MyD88/NF-κB signaling pathway and enhancing autophagy-related protein as well as CD31 and HIF-1α expression in skin tissues. This study showed that PVP/CS/DHM is a promising wound dressing | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Diabetic wound healing | |
650 | 4 | |a Dihydromyricetin | |
650 | 4 | |a Nanofiber membranes | |
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700 | 1 | |a Wang, Shijie |e verfasserin |4 aut | |
700 | 1 | |a Ding, Chuanbo |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Yingchun |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Shuai |e verfasserin |4 aut | |
700 | 1 | |a Sun, Shuwen |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Lifeng |e verfasserin |4 aut | |
700 | 1 | |a Ma, Shuang |e verfasserin |4 aut | |
700 | 1 | |a Ding, Qiteng |e verfasserin |4 aut | |
700 | 1 | |a Liu, Wencong |e verfasserin |4 aut | |
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