Investigation Into the Effects of Intra-Articular Steroid on Post-Traumatic Osteoarthritis in Distal Radius Fractures : A Randomized Controlled Pilot Study
Copyright © 2023 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved..
PURPOSE: The aim of this prospective, randomized, controlled, double-blinded pilot study was to determine the rates of post-traumatic osteoarthritis and assess joint space width in the presence or absence of a single intra-articular injection of corticosteroid after an acute, intra-articular distal radius fracture (DRF).
METHODS: Forty patients received a single, intra-articular, radiocarpal joint injection of 4 mg of dexamethasone (DEX) (n = 19) or normal saline placebo (n = 21) within 2 weeks of a surgically or nonsurgically treated intra-articular DRF. The primary outcome measure was minimum radiocarpal joint space width (mJSW) on noncontrast computed tomography scans at 2 years postinjection. Secondary outcomes were obtained at 3 months, 6 months, 1 year, and 2 years postinjection and included Disabilities of the Arm, Shoulder, and Hand; Michigan Hand Questionnaire; Patient-Rated Wrist Evaluation; wrist range of motion; and grip strength.
RESULTS: At 2-year follow-up, there was no difference in mean mJSW between the DEX group (2.2 mm; standard deviation, 0.6; range, 1.4-3.2) and the placebo group (2.3 mm; standard deviation, 0.7; range, 0.9-3.9). Further, there were no differences in any secondary outcome measures at any postinjection follow-up interval.
CONCLUSIONS: Radiocarpal joint injection of corticosteroid within 2 weeks of an intra-articular DRF does not appear to affect the development of post-traumatic osteoarthritis within 2 years follow-up in a small pilot cohort.
TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic II.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
The Journal of hand surgery - (2024) vom: 03. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Logli, Anthony L [VerfasserIn] |
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| Links: |
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| Themen: |
Corticosteroid |
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| Anmerkungen: |
Date Revised 05.01.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.jhsa.2023.11.026 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366710257 |
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| 100 | 1 | |a Logli, Anthony L |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Investigation Into the Effects of Intra-Articular Steroid on Post-Traumatic Osteoarthritis in Distal Radius Fractures |b A Randomized Controlled Pilot Study |
| 264 | 1 | |c 2024 | |
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| 520 | |a Copyright © 2023 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a PURPOSE: The aim of this prospective, randomized, controlled, double-blinded pilot study was to determine the rates of post-traumatic osteoarthritis and assess joint space width in the presence or absence of a single intra-articular injection of corticosteroid after an acute, intra-articular distal radius fracture (DRF) | ||
| 520 | |a METHODS: Forty patients received a single, intra-articular, radiocarpal joint injection of 4 mg of dexamethasone (DEX) (n = 19) or normal saline placebo (n = 21) within 2 weeks of a surgically or nonsurgically treated intra-articular DRF. The primary outcome measure was minimum radiocarpal joint space width (mJSW) on noncontrast computed tomography scans at 2 years postinjection. Secondary outcomes were obtained at 3 months, 6 months, 1 year, and 2 years postinjection and included Disabilities of the Arm, Shoulder, and Hand; Michigan Hand Questionnaire; Patient-Rated Wrist Evaluation; wrist range of motion; and grip strength | ||
| 520 | |a RESULTS: At 2-year follow-up, there was no difference in mean mJSW between the DEX group (2.2 mm; standard deviation, 0.6; range, 1.4-3.2) and the placebo group (2.3 mm; standard deviation, 0.7; range, 0.9-3.9). Further, there were no differences in any secondary outcome measures at any postinjection follow-up interval | ||
| 520 | |a CONCLUSIONS: Radiocarpal joint injection of corticosteroid within 2 weeks of an intra-articular DRF does not appear to affect the development of post-traumatic osteoarthritis within 2 years follow-up in a small pilot cohort | ||
| 520 | |a TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic II | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Corticosteroid | |
| 650 | 4 | |a dexamethasone (DEX) | |
| 650 | 4 | |a distal radius fracture (DRF) | |
| 650 | 4 | |a post-traumatic osteoarthritis (PTOA) | |
| 650 | 4 | |a randomized controlled trial (RCT) | |
| 700 | 1 | |a Evans, Christopher H |e verfasserin |4 aut | |
| 700 | 1 | |a Duryea, Jeffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Larson, Dirk R |e verfasserin |4 aut | |
| 700 | 1 | |a Bakri, Karim |e verfasserin |4 aut | |
| 700 | 1 | |a Carlsen, Brian T |e verfasserin |4 aut | |
| 700 | 1 | |a Dennison, David G |e verfasserin |4 aut | |
| 700 | 1 | |a Karim, Kristin E |e verfasserin |4 aut | |
| 700 | 1 | |a Pulos, Nicholas A |e verfasserin |4 aut | |
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| 700 | 1 | |a Elhassan, Bassem T |e verfasserin |4 aut | |
| 700 | 1 | |a Kakar, Sanjeev |e verfasserin |4 aut | |
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