The effect of deoxycholic acid-based hydrogels on hepatic, muscle and pancreatic beta cells
Aim: The aim of this study is to test the biocompatibility of hydrogels with polysaccharides and bile acids on three murine cell lines. Materials & methods: Novel hydrogels containing poloxamer 407, polysaccharides (starch, pectin, acacia, carboxymethyl and methyl 2-hydroxyethyl cellulose) and deoxycholic acid were prepared using cold method, sterilized and used in biological assays to determine effects on hepatic, muscle, and pancreatic beta cells. Results and conclusion: Hydrogels with deoxycholic acid had tissue-depending effects on cellular survival and bioenergetics, resulting in the best cellular viability and bioenergetics within pancreatic beta cells. Further research is needed as proposed hydrogels may be beneficial for cell delivery systems of pancreatic beta cells.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Therapeutic delivery - (2024) vom: 05. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kovacevic, Bozica [VerfasserIn] |
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| Links: |
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| Themen: |
Cellulose |
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| Anmerkungen: |
Date Revised 05.01.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.4155/tde-2023-0054 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366706160 |
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| 100 | 1 | |a Kovacevic, Bozica |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The effect of deoxycholic acid-based hydrogels on hepatic, muscle and pancreatic beta cells |
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| 500 | |a Date Revised 05.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Aim: The aim of this study is to test the biocompatibility of hydrogels with polysaccharides and bile acids on three murine cell lines. Materials & methods: Novel hydrogels containing poloxamer 407, polysaccharides (starch, pectin, acacia, carboxymethyl and methyl 2-hydroxyethyl cellulose) and deoxycholic acid were prepared using cold method, sterilized and used in biological assays to determine effects on hepatic, muscle, and pancreatic beta cells. Results and conclusion: Hydrogels with deoxycholic acid had tissue-depending effects on cellular survival and bioenergetics, resulting in the best cellular viability and bioenergetics within pancreatic beta cells. Further research is needed as proposed hydrogels may be beneficial for cell delivery systems of pancreatic beta cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a cellulose | |
| 650 | 4 | |a deoxycholic acid | |
| 650 | 4 | |a hydrogel | |
| 650 | 4 | |a pancreatic beta cells | |
| 650 | 4 | |a polysaccharide | |
| 700 | 1 | |a Jones, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Wagle, Susbin Raj |e verfasserin |4 aut | |
| 700 | 1 | |a Ionescu, Corina Mihaela |e verfasserin |4 aut | |
| 700 | 1 | |a Foster, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Đanić, Maja |e verfasserin |4 aut | |
| 700 | 1 | |a Mikov, Momir |e verfasserin |4 aut | |
| 700 | 1 | |a Mooranian, Armin |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Salami, Hani |e verfasserin |4 aut | |
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