Exploring antithrombin : insights into its physiological features, clinical implications and analytical techniques
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved..
Antithrombin is an essential protein that acts as a natural anticoagulant in the human body. It is synthesized by the liver and belongs to the serine protease inhibitors, which are commonly referred to as the SERPINS superfamily. The antithrombin molecule comprises 432 amino acids and has a molecular weight of approximately 58 200 D. It consists of three domains, including an amino-terminal domain, a carbohydrate-rich domain, and a carboxyl-terminal domain. The amino-terminal domain binds with heparin, whereas the carboxyl-terminal domain binds with serine protease. Antithrombin is a crucial natural anticoagulant that contributes approximately 60-80% of plasma anticoagulant activities in the human body. Moreover, antithrombin has anti-inflammatory effects that can be divided into coagulation-dependent and coagulation-independent effects. Furthermore, it exhibits antitumor activity and possesses a broad range of antiviral properties. Inherited type I antithrombin deficiency is a quantitative disorder that is characterized by low antithrombin activity due to low plasma levels. On the other hand, inherited type II antithrombin deficiency is a qualitative disorder that is characterized by defects in the antithrombin molecule. Acquired antithrombin deficiencies are more common than hereditary deficiencies and are associated with various clinical conditions due to reduced synthesis, increased loss, or enhanced consumption. The purpose of this review was to provide an update on the structure, functions, clinical implications, and methods of detection of antithrombin.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
---|---|
Enthalten in: |
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 35(2024), 2 vom: 01. März, Seite 43-48 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Saboor, Muhammad [VerfasserIn] |
---|
Links: |
---|
Themen: |
9000-94-6 |
---|
Anmerkungen: |
Date Completed 05.02.2024 Date Revised 08.03.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1097/MBC.0000000000001271 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM366703293 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM366703293 | ||
003 | DE-627 | ||
005 | 20240308232312.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240108s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1097/MBC.0000000000001271 |2 doi | |
028 | 5 | 2 | |a pubmed24n1320.xml |
035 | |a (DE-627)NLM366703293 | ||
035 | |a (NLM)38179715 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Saboor, Muhammad |e verfasserin |4 aut | |
245 | 1 | 0 | |a Exploring antithrombin |b insights into its physiological features, clinical implications and analytical techniques |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 05.02.2024 | ||
500 | |a Date Revised 08.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. | ||
520 | |a Antithrombin is an essential protein that acts as a natural anticoagulant in the human body. It is synthesized by the liver and belongs to the serine protease inhibitors, which are commonly referred to as the SERPINS superfamily. The antithrombin molecule comprises 432 amino acids and has a molecular weight of approximately 58 200 D. It consists of three domains, including an amino-terminal domain, a carbohydrate-rich domain, and a carboxyl-terminal domain. The amino-terminal domain binds with heparin, whereas the carboxyl-terminal domain binds with serine protease. Antithrombin is a crucial natural anticoagulant that contributes approximately 60-80% of plasma anticoagulant activities in the human body. Moreover, antithrombin has anti-inflammatory effects that can be divided into coagulation-dependent and coagulation-independent effects. Furthermore, it exhibits antitumor activity and possesses a broad range of antiviral properties. Inherited type I antithrombin deficiency is a quantitative disorder that is characterized by low antithrombin activity due to low plasma levels. On the other hand, inherited type II antithrombin deficiency is a qualitative disorder that is characterized by defects in the antithrombin molecule. Acquired antithrombin deficiencies are more common than hereditary deficiencies and are associated with various clinical conditions due to reduced synthesis, increased loss, or enhanced consumption. The purpose of this review was to provide an update on the structure, functions, clinical implications, and methods of detection of antithrombin | ||
650 | 4 | |a Review | |
650 | 4 | |a Journal Article | |
650 | 7 | |a Antithrombins |2 NLM | |
650 | 7 | |a Antithrombin III |2 NLM | |
650 | 7 | |a 9000-94-6 |2 NLM | |
650 | 7 | |a Anticoagulants |2 NLM | |
650 | 7 | |a Heparin |2 NLM | |
650 | 7 | |a 9005-49-6 |2 NLM | |
700 | 1 | |a Hamali, Hassan A |e verfasserin |4 aut | |
700 | 1 | |a Mobarki, Abdullah A |e verfasserin |4 aut | |
700 | 1 | |a Madkhali, Aymen M |e verfasserin |4 aut | |
700 | 1 | |a Dboie, Gasim |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis |d 1992 |g 35(2024), 2 vom: 01. März, Seite 43-48 |w (DE-627)NLM012606456 |x 1473-5733 |7 nnns |
773 | 1 | 8 | |g volume:35 |g year:2024 |g number:2 |g day:01 |g month:03 |g pages:43-48 |
856 | 4 | 0 | |u http://dx.doi.org/10.1097/MBC.0000000000001271 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 35 |j 2024 |e 2 |b 01 |c 03 |h 43-48 |