Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studies
© 2023 The Authors..
Recent advances in heart-on-a-chip systems hold great promise to facilitate cardiac physiological, pathological, and pharmacological studies. This review focuses on the development of heart-on-a-chip systems with tissue-specific functionalities. For one thing, the strategies for developing cardiac microtissues on heart-on-a-chip systems that closely mimic the structures and behaviors of the native heart are analyzed, including the imitation of cardiac structural and functional characteristics. For another, the development of techniques for real-time monitoring of biophysical and biochemical signals from cardiac microtissues on heart-on-a-chip systems is introduced, incorporating cardiac electrophysiological signals, contractile activity, and biomarkers. Furthermore, the applications of heart-on-a-chip systems in intelligent cardiac studies are discussed regarding physiological/pathological research and pharmacological assessment. Finally, the future development of heart-on-a-chip toward a higher level of systematization, integration, and maturation is proposed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Materials today. Bio - 24(2024) vom: 24. Jan., Seite 100914 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gu, Bingsong [VerfasserIn] |
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| Links: |
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| Themen: |
Biosensing |
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| Anmerkungen: |
Date Revised 06.01.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.mtbio.2023.100914 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366700448 |
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| 520 | |a © 2023 The Authors. | ||
| 520 | |a Recent advances in heart-on-a-chip systems hold great promise to facilitate cardiac physiological, pathological, and pharmacological studies. This review focuses on the development of heart-on-a-chip systems with tissue-specific functionalities. For one thing, the strategies for developing cardiac microtissues on heart-on-a-chip systems that closely mimic the structures and behaviors of the native heart are analyzed, including the imitation of cardiac structural and functional characteristics. For another, the development of techniques for real-time monitoring of biophysical and biochemical signals from cardiac microtissues on heart-on-a-chip systems is introduced, incorporating cardiac electrophysiological signals, contractile activity, and biomarkers. Furthermore, the applications of heart-on-a-chip systems in intelligent cardiac studies are discussed regarding physiological/pathological research and pharmacological assessment. Finally, the future development of heart-on-a-chip toward a higher level of systematization, integration, and maturation is proposed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Biosensing | |
| 650 | 4 | |a Cardiac tissue | |
| 650 | 4 | |a Heart-on-a-chip | |
| 650 | 4 | |a Pathological modeling | |
| 650 | 4 | |a Pharmacological study | |
| 650 | 4 | |a Physiological behavior | |
| 700 | 1 | |a Han, Kang |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Hanbo |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Xinxin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiao |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Mao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Hu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Dichen |e verfasserin |4 aut | |
| 700 | 1 | |a He, Jiankang |e verfasserin |4 aut | |
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