Muscle abnormalities worsen after post-exertional malaise in long COVID
© 2024. The Author(s)..
A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is post-exertional malaise, which is associated with a worsening of fatigue- and pain-related symptoms after acute mental or physical exercise, but its underlying pathophysiology is unclear. With this longitudinal case-control study (NCT05225688), we provide new insights into the pathophysiology of post-exertional malaise in patients with long COVID. We show that skeletal muscle structure is associated with a lower exercise capacity in patients, and local and systemic metabolic disturbances, severe exercise-induced myopathy and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID worsen after induction of post-exertional malaise. This study highlights novel pathways that help to understand the pathophysiology of post-exertional malaise in patients suffering from long COVID and other post-infectious diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Nature communications - 15(2024), 1 vom: 04. Jan., Seite 17 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Appelman, Brent [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 08.01.2024 Date Revised 18.04.2024 published: Electronic ClinicalTrials.gov: NCT05225688 Citation Status MEDLINE |
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| doi: |
10.1038/s41467-023-44432-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a ClinicalTrials.gov: NCT05225688 | ||
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| 520 | |a © 2024. The Author(s). | ||
| 520 | |a A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is post-exertional malaise, which is associated with a worsening of fatigue- and pain-related symptoms after acute mental or physical exercise, but its underlying pathophysiology is unclear. With this longitudinal case-control study (NCT05225688), we provide new insights into the pathophysiology of post-exertional malaise in patients with long COVID. We show that skeletal muscle structure is associated with a lower exercise capacity in patients, and local and systemic metabolic disturbances, severe exercise-induced myopathy and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID worsen after induction of post-exertional malaise. This study highlights novel pathways that help to understand the pathophysiology of post-exertional malaise in patients suffering from long COVID and other post-infectious diseases | ||
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| 700 | 1 | |a Goulding, Richie P |e verfasserin |4 aut | |
| 700 | 1 | |a Kerkhoff, Tom J |e verfasserin |4 aut | |
| 700 | 1 | |a Breedveld, Ellen A |e verfasserin |4 aut | |
| 700 | 1 | |a Noort, Wendy |e verfasserin |4 aut | |
| 700 | 1 | |a Offringa, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Bloemers, Frank W |e verfasserin |4 aut | |
| 700 | 1 | |a van Weeghel, Michel |e verfasserin |4 aut | |
| 700 | 1 | |a Schomakers, Bauke V |e verfasserin |4 aut | |
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| 700 | 1 | |a van Vugt, Michèle |e verfasserin |4 aut | |
| 700 | 1 | |a Wüst, Rob C I |e verfasserin |4 aut | |
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