The distal-proximal relationships among the human moonlighting proteins : Evolutionary hotspots and Darwinian checkpoints
Copyright © 2024 Elsevier B.V. All rights reserved..
Moonlighting proteins, known for their ability to perform multiple, often unrelated functions within a single polypeptide chain, challenge the traditional "one gene, one protein, one function" paradigm. As organisms evolved, their genomes remained relatively stable in size, but the introduction of post-translational modifications and sub-strategies like protein promiscuity and intrinsic disorder enabled multifunctionality. Enzymes, in particular, exemplify this phenomenon, engaging in unrelated processes alongside their primary catalytic roles. This study employs a systematic, quantitative informatics approach to shed light on human moonlighting protein sequences. Phylogenetic analyses of human moonlighting proteins are presented, elucidating the distal-proximal relationships among these proteins based on sequence-derived quantitative features. The findings unveil the captivating world of human moonlighting proteins, urging further investigations in the emerging field of moonlighting proteomics, with the potential for significant contributions to our understanding of multifunctional proteins and their roles in diverse cellular processes and diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:259 |
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| Enthalten in: |
International journal of biological macromolecules - 259(2024), Pt 1 vom: 05. Feb., Seite 128998 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nawn, Debaleena [VerfasserIn] |
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| Links: |
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| Themen: |
Distal-proximal |
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| Anmerkungen: |
Date Completed 22.02.2024 Date Revised 22.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijbiomac.2023.128998 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a Moonlighting proteins, known for their ability to perform multiple, often unrelated functions within a single polypeptide chain, challenge the traditional "one gene, one protein, one function" paradigm. As organisms evolved, their genomes remained relatively stable in size, but the introduction of post-translational modifications and sub-strategies like protein promiscuity and intrinsic disorder enabled multifunctionality. Enzymes, in particular, exemplify this phenomenon, engaging in unrelated processes alongside their primary catalytic roles. This study employs a systematic, quantitative informatics approach to shed light on human moonlighting protein sequences. Phylogenetic analyses of human moonlighting proteins are presented, elucidating the distal-proximal relationships among these proteins based on sequence-derived quantitative features. The findings unveil the captivating world of human moonlighting proteins, urging further investigations in the emerging field of moonlighting proteomics, with the potential for significant contributions to our understanding of multifunctional proteins and their roles in diverse cellular processes and diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Distal-proximal | |
| 650 | 4 | |a Moonlighting proteins | |
| 650 | 4 | |a Phylogeny | |
| 650 | 4 | |a Promiscuous proteins | |
| 650 | 4 | |a Signature-features | |
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| 700 | 1 | |a Hassan, Sk Sarif |e verfasserin |4 aut | |
| 700 | 1 | |a Sil, Moumita |e verfasserin |4 aut | |
| 700 | 1 | |a Ghosh, Ankita |e verfasserin |4 aut | |
| 700 | 1 | |a Goswami, Arunava |e verfasserin |4 aut | |
| 700 | 1 | |a Basu, Pallab |e verfasserin |4 aut | |
| 700 | 1 | |a Dayhoff, Guy W |c 2nd |e verfasserin |4 aut | |
| 700 | 1 | |a Lundstrom, Kenneth |e verfasserin |4 aut | |
| 700 | 1 | |a Uversky, Vladimir N |e verfasserin |4 aut | |
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