Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
© 2024 Bastard et al..
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:221 |
|---|---|
| Enthalten in: |
The Journal of experimental medicine - 221(2024), 2 vom: 05. Feb. |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
Autoantibodies |
|---|
| Anmerkungen: |
Date Completed 08.01.2024 Date Revised 26.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1084/jem.20231353 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM366665820 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM366665820 | ||
| 003 | DE-627 | ||
| 005 | 20240426233518.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240108s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1084/jem.20231353 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1388.xml |
| 035 | |a (DE-627)NLM366665820 | ||
| 035 | |a (NLM)38175961 | ||
| 035 | |a (PII)e20231353 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Bastard, Paul |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.01.2024 | ||
| 500 | |a Date Revised 26.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 Bastard et al. | ||
| 520 | |a We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Interferon-alpha |2 NLM | |
| 650 | 7 | |a Interferon Type I |2 NLM | |
| 650 | 7 | |a Autoantibodies |2 NLM | |
| 700 | 1 | |a Gervais, Adrian |e verfasserin |4 aut | |
| 700 | 1 | |a Taniguchi, Maki |e verfasserin |4 aut | |
| 700 | 1 | |a Saare, Liisa |e verfasserin |4 aut | |
| 700 | 1 | |a Särekannu, Karita |e verfasserin |4 aut | |
| 700 | 1 | |a Le Voyer, Tom |e verfasserin |4 aut | |
| 700 | 1 | |a Philippot, Quentin |e verfasserin |4 aut | |
| 700 | 1 | |a Rosain, Jérémie |e verfasserin |4 aut | |
| 700 | 1 | |a Bizien, Lucy |e verfasserin |4 aut | |
| 700 | 1 | |a Asano, Takaki |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia-Prat, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Parra-Martínez, Alba |e verfasserin |4 aut | |
| 700 | 1 | |a Migaud, Mélanie |e verfasserin |4 aut | |
| 700 | 1 | |a Tsumura, Miyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Conti, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Belot, Alexandre |e verfasserin |4 aut | |
| 700 | 1 | |a Rivière, Jacques G |e verfasserin |4 aut | |
| 700 | 1 | |a Morio, Tomohiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Junko |e verfasserin |4 aut | |
| 700 | 1 | |a Javouhey, Etienne |e verfasserin |4 aut | |
| 700 | 1 | |a Haerynck, Filomeen |e verfasserin |4 aut | |
| 700 | 1 | |a Duvlis, Sotirija |e verfasserin |4 aut | |
| 700 | 1 | |a Ozcelik, Tayfun |e verfasserin |4 aut | |
| 700 | 1 | |a Keles, Sevgi |e verfasserin |4 aut | |
| 700 | 1 | |a Tandjaoui-Lambiotte, Yacine |e verfasserin |4 aut | |
| 700 | 1 | |a Escoda, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Husain, Maya |e verfasserin |4 aut | |
| 700 | 1 | |a Pan-Hammarström, Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Hammarström, Lennart |e verfasserin |4 aut | |
| 700 | 1 | |a Ahlijah, Gloria |e verfasserin |4 aut | |
| 700 | 1 | |a Abi Haidar, Anthony |e verfasserin |4 aut | |
| 700 | 1 | |a Soudee, Camille |e verfasserin |4 aut | |
| 700 | 1 | |a Arseguel, Vincent |e verfasserin |4 aut | |
| 700 | 1 | |a Abolhassani, Hassan |e verfasserin |4 aut | |
| 700 | 1 | |a Sahanic, Sabina |e verfasserin |4 aut | |
| 700 | 1 | |a Tancevski, Ivan |e verfasserin |4 aut | |
| 700 | 1 | |a Nukui, Yoko |e verfasserin |4 aut | |
| 700 | 1 | |a Hayakawa, Seiichi |e verfasserin |4 aut | |
| 700 | 1 | |a Chrousos, George P |e verfasserin |4 aut | |
| 700 | 1 | |a Michos, Athanasios |e verfasserin |4 aut | |
| 700 | 1 | |a Tatsi, Elizabeth-Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Filippatos, Filippos |e verfasserin |4 aut | |
| 700 | 1 | |a Rodriguez-Palmero, Agusti |e verfasserin |4 aut | |
| 700 | 1 | |a Troya, Jesus |e verfasserin |4 aut | |
| 700 | 1 | |a Tipu, Imran |e verfasserin |4 aut | |
| 700 | 1 | |a Meyts, Isabelle |e verfasserin |4 aut | |
| 700 | 1 | |a Roussel, Lucie |e verfasserin |4 aut | |
| 700 | 1 | |a Ostrowski, Sisse Rye |e verfasserin |4 aut | |
| 700 | 1 | |a Schidlowski, Laire |e verfasserin |4 aut | |
| 700 | 1 | |a Prando, Carolina |e verfasserin |4 aut | |
| 700 | 1 | |a Condino-Neto, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Cheikh, Nathalie |e verfasserin |4 aut | |
| 700 | 1 | |a Bousfiha, Ahmed A |e verfasserin |4 aut | |
| 700 | 1 | |a El Bakkouri, Jalila |e verfasserin |4 aut | |
| 700 | 0 | |a COVID Clinicians |e verfasserin |4 aut | |
| 700 | 0 | |a GEN-COVID Study Group |e verfasserin |4 aut | |
| 700 | 0 | |a COVID Human Genetic Effort |e verfasserin |4 aut | |
| 700 | 1 | |a Peterson, Pärt |e verfasserin |4 aut | |
| 700 | 1 | |a Pujol, Aurora |e verfasserin |4 aut | |
| 700 | 1 | |a Lévy, Romain |e verfasserin |4 aut | |
| 700 | 1 | |a Quartier, Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Vinh, Donald C |e verfasserin |4 aut | |
| 700 | 1 | |a Boisson, Bertrand |e verfasserin |4 aut | |
| 700 | 1 | |a Béziat, Vivien |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Shen-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Borghesi, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Pession, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Andreakos, Evangelos |e verfasserin |4 aut | |
| 700 | 1 | |a Marr, Nico |e verfasserin |4 aut | |
| 700 | 1 | |a Mentis, Alexios-Fotios A |e verfasserin |4 aut | |
| 700 | 1 | |a Mogensen, Trine H |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Gallego, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Soler-Palacin, Pere |e verfasserin |4 aut | |
| 700 | 1 | |a Colobran, Roger |e verfasserin |4 aut | |
| 700 | 1 | |a Tillmann, Vallo |e verfasserin |4 aut | |
| 700 | 1 | |a Neven, Bénédicte |e verfasserin |4 aut | |
| 700 | 1 | |a Trouillet-Assant, Sophie |e verfasserin |4 aut | |
| 700 | 1 | |a Brodin, Petter |e verfasserin |4 aut | |
| 700 | 1 | |a Abel, Laurent |e verfasserin |4 aut | |
| 700 | 1 | |a Jouanguy, Emmanuelle |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Martinón-Torres, Federico |e verfasserin |4 aut | |
| 700 | 1 | |a Salas, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez-Carballa, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Gonzalez-Granado, Luis I |e verfasserin |4 aut | |
| 700 | 1 | |a Kisand, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Okada, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Puel, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Cobat, Aurélie |e verfasserin |4 aut | |
| 700 | 1 | |a Casanova, Jean-Laurent |e verfasserin |4 aut | |
| 700 | 1 | |a Aguilera-Albesa, Sergio |e investigator |4 oth | |
| 700 | 1 | |a AlKhater, Suzan A |e investigator |4 oth | |
| 700 | 1 | |a Alkan, Gulsum |e investigator |4 oth | |
| 700 | 1 | |a Castagnoli, Riccardo |e investigator |4 oth | |
| 700 | 1 | |a Cyrus, Cyril |e investigator |4 oth | |
| 700 | 1 | |a Elmas Bozdemir, Sefika |e investigator |4 oth | |
| 700 | 1 | |a Emiroglu, Melike |e investigator |4 oth | |
| 700 | 1 | |a Gulhan, Belgin |e investigator |4 oth | |
| 700 | 1 | |a Erdeniz, Emine Hafize |e investigator |4 oth | |
| 700 | 1 | |a Hatipoglu, Nevin |e investigator |4 oth | |
| 700 | 1 | |a Bayhan, Gülsün Iclal |e investigator |4 oth | |
| 700 | 1 | |a Jabandziev, Petr |e investigator |4 oth | |
| 700 | 1 | |a Kanik Yuksek, Saliha |e investigator |4 oth | |
| 700 | 1 | |a Karbuz, Adem |e investigator |4 oth | |
| 700 | 1 | |a Tüter Öz, Şadiye Kübra |e investigator |4 oth | |
| 700 | 1 | |a Marseglia, Gian Luigi |e investigator |4 oth | |
| 700 | 1 | |a Metin Akcan, Ozge |e investigator |4 oth | |
| 700 | 1 | |a Kılıç, Ahmet Osman |e investigator |4 oth | |
| 700 | 1 | |a Ozkaya Parlakay, Aslinur |e investigator |4 oth | |
| 700 | 1 | |a Papadaki, Maria |e investigator |4 oth | |
| 700 | 1 | |a Slaba, Katerina |e investigator |4 oth | |
| 700 | 1 | |a Sevketoglu, Esra |e investigator |4 oth | |
| 700 | 1 | |a Valencia-Ramos, Juan |e investigator |4 oth | |
| 700 | 1 | |a Yahşi, Aysun |e investigator |4 oth | |
| 700 | 1 | |a Aguilera Guirao, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Álvarez Escudero, Julián |e investigator |4 oth | |
| 700 | 1 | |a Antela López, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Barbeito Castiñeiras, Gema |e investigator |4 oth | |
| 700 | 1 | |a Bello Paderne, Xabier |e investigator |4 oth | |
| 700 | 1 | |a Ben García, Miriam |e investigator |4 oth | |
| 700 | 1 | |a Carral García, María Victoria |e investigator |4 oth | |
| 700 | 1 | |a Cebey López, Miriam |e investigator |4 oth | |
| 700 | 1 | |a Coira Nieto, Amparo |e investigator |4 oth | |
| 700 | 1 | |a Conde Pájaro, Mónica |e investigator |4 oth | |
| 700 | 1 | |a Costa Alcalde, José Javier |e investigator |4 oth | |
| 700 | 1 | |a Currás Tuala, María José |e investigator |4 oth | |
| 700 | 1 | |a Dacosta Urbieta, Ana Isabel |e investigator |4 oth | |
| 700 | 1 | |a Díaz Esteban, Blanca |e investigator |4 oth | |
| 700 | 1 | |a Domínguez Santalla, María Jesús |e investigator |4 oth | |
| 700 | 1 | |a Fernández Pérez, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Fernández Villaverde, Juan |e investigator |4 oth | |
| 700 | 1 | |a Galbán Rodríguez, Cristóbal |e investigator |4 oth | |
| 700 | 1 | |a García Allut, José Luis |e investigator |4 oth | |
| 700 | 1 | |a García Vicente, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Giráldez Vázquez, Elena |e investigator |4 oth | |
| 700 | 1 | |a Gómez Carballa, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Gómez Rial, José |e investigator |4 oth | |
| 700 | 1 | |a González Barcala, Francisco Javier |e investigator |4 oth | |
| 700 | 1 | |a Guerra Liñares, Beatriz |e investigator |4 oth | |
| 700 | 1 | |a Leboráns Iglesias, Pilar |e investigator |4 oth | |
| 700 | 1 | |a Lence Massa, Beatriz |e investigator |4 oth | |
| 700 | 1 | |a Lendoiro Fuentes, Marta |e investigator |4 oth | |
| 700 | 1 | |a López Franco, Montserrat |e investigator |4 oth | |
| 700 | 1 | |a López Lago, Ana |e investigator |4 oth | |
| 700 | 1 | |a Martinón-Torres, Federico |e investigator |4 oth | |
| 700 | 1 | |a Salas, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Navarro De la Cruz, Daniel |e investigator |4 oth | |
| 700 | 1 | |a Núñez Masid, Eloína |e investigator |4 oth | |
| 700 | 1 | |a Ortolá Devesa, Juan Bautista |e investigator |4 oth | |
| 700 | 1 | |a Pardo Seco, Jacobo |e investigator |4 oth | |
| 700 | 1 | |a Pazo Núñez, María |e investigator |4 oth | |
| 700 | 1 | |a Pérez Del Molino Bernal, Marisa |e investigator |4 oth | |
| 700 | 1 | |a Pérez Freixo, Hugo |e investigator |4 oth | |
| 700 | 1 | |a Piñeiro Rodríguez, Lidia |e investigator |4 oth | |
| 700 | 1 | |a Pischedda, Sara |e investigator |4 oth | |
| 700 | 1 | |a Portela Romero, Manuel |e investigator |4 oth | |
| 700 | 1 | |a Pose Reino, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Prada Hervella, Gloria María |e investigator |4 oth | |
| 700 | 1 | |a Queiro Verdes, Teresa |e investigator |4 oth | |
| 700 | 1 | |a Redondo Collazo, Lorenzo |e investigator |4 oth | |
| 700 | 1 | |a Regueiro Casuso, Patricia |e investigator |4 oth | |
| 700 | 1 | |a Rey García, Susana |e investigator |4 oth | |
| 700 | 1 | |a Rey Vázquez, Sara |e investigator |4 oth | |
| 700 | 1 | |a Riveiro Blanco, Vanessa |e investigator |4 oth | |
| 700 | 1 | |a Rivero Calle, Irene |e investigator |4 oth | |
| 700 | 1 | |a Rivero Velasco, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez Núñez, Nuria |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-Tenreiro Sánchez, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Saborido Paz, Eva |e investigator |4 oth | |
| 700 | 1 | |a Sadiki Orayyou, José Miguel |e investigator |4 oth | |
| 700 | 1 | |a Saito Villanueva, Carla |e investigator |4 oth | |
| 700 | 1 | |a Serén Fernández, Sonia |e investigator |4 oth | |
| 700 | 1 | |a Souto Sanmartín, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Taboada Muñiz, Manuel |e investigator |4 oth | |
| 700 | 1 | |a Trastoy Pena, Rocío |e investigator |4 oth | |
| 700 | 1 | |a Treviño Castellano, Mercedes |e investigator |4 oth | |
| 700 | 1 | |a Valdés Cuadrado, Luis |e investigator |4 oth | |
| 700 | 1 | |a Varela García, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Vilas Iglesias, María Soledad |e investigator |4 oth | |
| 700 | 1 | |a Viz Lasheras, Sandra |e investigator |4 oth | |
| 700 | 1 | |a Ferreiro-Iglesias, Rocio |e investigator |4 oth | |
| 700 | 1 | |a Bastón-Rey, Iria |e investigator |4 oth | |
| 700 | 1 | |a Calviño-Suárez, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Abel, Laurent |e investigator |4 oth | |
| 700 | 1 | |a Aiuti, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Al-Muhsen, Saleh |e investigator |4 oth | |
| 700 | 1 | |a Al-Mulla, Fahd |e investigator |4 oth | |
| 700 | 1 | |a Amara, Ali |e investigator |4 oth | |
| 700 | 1 | |a Anderson, Mark S |e investigator |4 oth | |
| 700 | 1 | |a Andreakos, Evangelos |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of experimental medicine |d 1896 |g 221(2024), 2 vom: 05. Feb. |w (DE-627)NLM000005967 |x 1540-9538 |7 nnns |
| 773 | 1 | 8 | |g volume:221 |g year:2024 |g number:2 |g day:05 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1084/jem.20231353 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 221 |j 2024 |e 2 |b 05 |c 02 | ||