Recipient-associated risk factors for post-liver transplantation biliary complications : A cohort study
© 2024. Indian Society of Gastroenterology..
INTRODUCTION: Biliary complications (BCs) are a well-documented post-liver transplantation concern with potential implications for patient survival. This study aims at identifying risk factors associated with the development of BCs in recipients after liver transplantation (LT) and exploring strategies for their management.
METHODS: We conducted a retrospective analysis of 1595 adult patients (age > 18 years) who underwent LT surgery between 2019 and 2021. The study assessed the incidence of BCs in this cohort.
RESULTS: Of 1595 patients, 178 (11.1%) experienced BCs, while 1417 (88.8%) did not exhibit any signs of such complications. Patients who developed BCs were found to have a significantly lower average age (p < 0.001) and longer cold ischemic times (p < 0.001) compared to those without BCs. Variables such as sex, body mass index (BMI), model for end-stage liver disease (MELD) score, primary diagnosis, type of anastomosis, hepatectomy technique, type of transplanted liver and mortality did not demonstrate statistically significant differences between the two groups (p > 0.05). Univariate logistic regression analysis revealed that a cold ischemic time exceeding 12 hours and duct-to-duct anastomosis were positive predictors for BC development (odds ratios of 6.23 [CI 4.29-9.02] and 1.47 [CI 0.94-2.30], respectively). Conversely, increasing age was associated with a protective effect against BC development, with an odds ratio of 0.64 (CI 0.46-0.89).
CONCLUSION: Our multi-variate analysis identified cold ischemia time (CIT) as the sole significant predictor of post-liver transplantation biliary complications. Additionally, this study observed that advancing patient age had a protective influence in this context. Notably, no significant disparities were detected between hepatectomy techniques and the etiology of liver disease types in the two study groups.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology - (2024) vom: 03. Jan. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mosallaie Pour, Hamid Reza [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Biliary tract diseases |
|---|
| Anmerkungen: |
Date Revised 03.01.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1007/s12664-023-01479-w |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM366630806 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM366630806 | ||
| 003 | DE-627 | ||
| 005 | 20240108141926.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240108s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12664-023-01479-w |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1248.xml |
| 035 | |a (DE-627)NLM366630806 | ||
| 035 | |a (NLM)38172464 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mosallaie Pour, Hamid Reza |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Recipient-associated risk factors for post-liver transplantation biliary complications |b A cohort study |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 03.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2024. Indian Society of Gastroenterology. | ||
| 520 | |a INTRODUCTION: Biliary complications (BCs) are a well-documented post-liver transplantation concern with potential implications for patient survival. This study aims at identifying risk factors associated with the development of BCs in recipients after liver transplantation (LT) and exploring strategies for their management | ||
| 520 | |a METHODS: We conducted a retrospective analysis of 1595 adult patients (age > 18 years) who underwent LT surgery between 2019 and 2021. The study assessed the incidence of BCs in this cohort | ||
| 520 | |a RESULTS: Of 1595 patients, 178 (11.1%) experienced BCs, while 1417 (88.8%) did not exhibit any signs of such complications. Patients who developed BCs were found to have a significantly lower average age (p < 0.001) and longer cold ischemic times (p < 0.001) compared to those without BCs. Variables such as sex, body mass index (BMI), model for end-stage liver disease (MELD) score, primary diagnosis, type of anastomosis, hepatectomy technique, type of transplanted liver and mortality did not demonstrate statistically significant differences between the two groups (p > 0.05). Univariate logistic regression analysis revealed that a cold ischemic time exceeding 12 hours and duct-to-duct anastomosis were positive predictors for BC development (odds ratios of 6.23 [CI 4.29-9.02] and 1.47 [CI 0.94-2.30], respectively). Conversely, increasing age was associated with a protective effect against BC development, with an odds ratio of 0.64 (CI 0.46-0.89) | ||
| 520 | |a CONCLUSION: Our multi-variate analysis identified cold ischemia time (CIT) as the sole significant predictor of post-liver transplantation biliary complications. Additionally, this study observed that advancing patient age had a protective influence in this context. Notably, no significant disparities were detected between hepatectomy techniques and the etiology of liver disease types in the two study groups | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biliary tract diseases | |
| 650 | 4 | |a Cohort studies | |
| 650 | 4 | |a Liver donors | |
| 650 | 4 | |a Liver transplantation | |
| 650 | 4 | |a Post-operative complications | |
| 700 | 1 | |a Sivandzadeh, Gholam Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Ejtehadi, Fardad |e verfasserin |4 aut | |
| 700 | 1 | |a Safarpour, Ali Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Shahramian, Iraj |e verfasserin |4 aut | |
| 700 | 1 | |a Tahani, Masoud |e verfasserin |4 aut | |
| 700 | 1 | |a Taghavi, Seyed Alireza |e verfasserin |4 aut | |
| 700 | 1 | |a Aminisefat, Alireza |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology |d 1993 |g (2024) vom: 03. Jan. |w (DE-627)NLM012713031 |x 0975-0711 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:03 |g month:01 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s12664-023-01479-w |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 03 |c 01 | ||