Carnosine supplementation improves glucose control in adults with pre-diabetes and type 2 diabetes : A randomised controlled trial
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved..
BACKGROUND AND AIMS: Type 2 diabetes (T2DM) is a major cause of morbidity and mortality globally. Carnosine, a naturally occurring dipeptide, has anti-inflammatory, antioxidant, and anti-glycating effects, with preliminary evidence suggesting it may improve important chronic disease risk factors in adults with cardiometabolic conditions.
METHODS AND RESULTS: In this randomised controlled trial, 43 adults (30%F) living with prediabetes or T2DM consumed carnosine (2 g) or a matching placebo daily for 14 weeks to evaluate its effect on glucose metabolism assessed via a 2-h 75 g oral glucose tolerance test. Secondary outcomes included body composition analysis by dual energy x-ray absorptiometry (DEXA), calf muscle density by pQCT, and anthropometry. Carnosine supplementation decreased blood glucose at 90 min (-1.31 mmol/L; p = 0.02) and 120 min (-1.60 mmol/L, p = 0.02) and total glucose area under the curve (-3.30 mmol/L; p = 0.04) following an oral glucose tolerance test. There were no additional changes in secondary outcomes. The carnosine group results remained significant before and after adjustment for age, sex, and change in weight (all>0.05), and in further sensitivity analyses accounting for missing data. There were no significant changes in insulin levels.
CONCLUSION: This study provides preliminary support for larger trials evaluating carnosine as a potential treatment for prediabetes and the initial stages of T2DM. Likely mechanisms may include changes to hepatic glucose output explaining the observed reduction in blood glucose without changes in insulin secretion following carnosine supplementation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Nutrition, metabolism, and cardiovascular diseases : NMCD - 34(2024), 2 vom: 29. Feb., Seite 485-496 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hariharan, Rohit [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
8HO6PVN24W |
|---|
| Anmerkungen: |
Date Completed 04.03.2024 Date Revised 01.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.numecd.2023.10.012 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM366626205 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM366626205 | ||
| 003 | DE-627 | ||
| 005 | 20240401232506.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240108s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.numecd.2023.10.012 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1359.xml |
| 035 | |a (DE-627)NLM366626205 | ||
| 035 | |a (NLM)38172006 | ||
| 035 | |a (PII)S0939-4753(23)00419-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hariharan, Rohit |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Carnosine supplementation improves glucose control in adults with pre-diabetes and type 2 diabetes |b A randomised controlled trial |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 04.03.2024 | ||
| 500 | |a Date Revised 01.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND AND AIMS: Type 2 diabetes (T2DM) is a major cause of morbidity and mortality globally. Carnosine, a naturally occurring dipeptide, has anti-inflammatory, antioxidant, and anti-glycating effects, with preliminary evidence suggesting it may improve important chronic disease risk factors in adults with cardiometabolic conditions | ||
| 520 | |a METHODS AND RESULTS: In this randomised controlled trial, 43 adults (30%F) living with prediabetes or T2DM consumed carnosine (2 g) or a matching placebo daily for 14 weeks to evaluate its effect on glucose metabolism assessed via a 2-h 75 g oral glucose tolerance test. Secondary outcomes included body composition analysis by dual energy x-ray absorptiometry (DEXA), calf muscle density by pQCT, and anthropometry. Carnosine supplementation decreased blood glucose at 90 min (-1.31 mmol/L; p = 0.02) and 120 min (-1.60 mmol/L, p = 0.02) and total glucose area under the curve (-3.30 mmol/L; p = 0.04) following an oral glucose tolerance test. There were no additional changes in secondary outcomes. The carnosine group results remained significant before and after adjustment for age, sex, and change in weight (all>0.05), and in further sensitivity analyses accounting for missing data. There were no significant changes in insulin levels | ||
| 520 | |a CONCLUSION: This study provides preliminary support for larger trials evaluating carnosine as a potential treatment for prediabetes and the initial stages of T2DM. Likely mechanisms may include changes to hepatic glucose output explaining the observed reduction in blood glucose without changes in insulin secretion following carnosine supplementation | ||
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anthropometry | |
| 650 | 4 | |a Carnosine | |
| 650 | 4 | |a Clinical trial | |
| 650 | 4 | |a Diabetes | |
| 650 | 4 | |a Diabetes treatment | |
| 650 | 4 | |a Histidine containing dipeptides | |
| 650 | 4 | |a Muscle quality | |
| 650 | 7 | |a Blood Glucose |2 NLM | |
| 650 | 7 | |a Carnosine |2 NLM | |
| 650 | 7 | |a 8HO6PVN24W |2 NLM | |
| 650 | 7 | |a Glucose |2 NLM | |
| 650 | 7 | |a IY9XDZ35W2 |2 NLM | |
| 700 | 1 | |a Cameron, James |e verfasserin |4 aut | |
| 700 | 1 | |a Menon, Kirthi |e verfasserin |4 aut | |
| 700 | 1 | |a Mesinovic, Jakub |e verfasserin |4 aut | |
| 700 | 1 | |a Jansons, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Scott, David |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Zhong X |e verfasserin |4 aut | |
| 700 | 1 | |a de Courten, Maximilian |e verfasserin |4 aut | |
| 700 | 1 | |a Feehan, Jack |e verfasserin |4 aut | |
| 700 | 1 | |a de Courten, Barbora |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nutrition, metabolism, and cardiovascular diseases : NMCD |d 1997 |g 34(2024), 2 vom: 29. Feb., Seite 485-496 |w (DE-627)NLM090675177 |x 1590-3729 |7 nnns |
| 773 | 1 | 8 | |g volume:34 |g year:2024 |g number:2 |g day:29 |g month:02 |g pages:485-496 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.numecd.2023.10.012 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 34 |j 2024 |e 2 |b 29 |c 02 |h 485-496 | ||