Molecular effects of polystyrene nanoplastics on human neural stem cells
Copyright: © 2024 Martin-Folgar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..
Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs´ mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) after 4 days of exposure to 30 nm polystyrene (PS) NPs (0.5, 2.5 and 10 μg/mL). Our results showed that NPs can induce oxidative stress, cellular stress, DNA damage, alterations in inflammatory response, and apoptosis, which could lead to tissue damage and neurodevelopmental diseases.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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Enthalten in: |
PloS one - 19(2024), 1 vom: 31., Seite e0295816 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Martin-Folgar, Raquel [VerfasserIn] |
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Themen: |
Journal Article |
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Anmerkungen: |
Date Completed 05.01.2024 Date Revised 06.01.2024 published: Electronic-eCollection Citation Status MEDLINE |
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doi: |
10.1371/journal.pone.0295816 |
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funding: |
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PPN (Katalog-ID): |
NLM366613227 |
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520 | |a Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs´ mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) after 4 days of exposure to 30 nm polystyrene (PS) NPs (0.5, 2.5 and 10 μg/mL). Our results showed that NPs can induce oxidative stress, cellular stress, DNA damage, alterations in inflammatory response, and apoptosis, which could lead to tissue damage and neurodevelopmental diseases | ||
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700 | 1 | |a Liste, Isabel |e verfasserin |4 aut | |
700 | 1 | |a Morales, Mónica |e verfasserin |4 aut | |
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