Differences in PPD- and mitogen-induced T-cell activation marker expression characterize immunopathology in acute tuberculosis patients
© 2024. The Author(s)..
Impaired T-cell responses to mitogens and high T-cell activation marker (TAM) expression on Mycobacterium tuberculosis-specific T-cells characterize immunopathology in patients with tuberculosis (TB). In a study of patients with TB (n = 60) and asymptomatic contacts (controls, n = 37), we found that TB patients had higher CD38+ T-cell proportions specific for M. tuberculosis protein (PPDMtb), yet total proportions of PPDMtb-specific T-cells were comparable. Notably, both activated (CD38+) and total IFN-γ+ T-cells from TB patients had lower mitogen (phytohemagglutinin, PHA)-induced responses. This impaired mitogen response improved the classification efficacy of the TAM-TB assay, especially employing the PPD/PHA-induced T-cell ratio.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 43(2024), 3 vom: 02. März, Seite 611-616 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Acheampong, Isaac [VerfasserIn] |
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| Links: |
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| Themen: |
Anergy |
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| Anmerkungen: |
Date Completed 07.03.2024 Date Revised 09.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10096-023-04741-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366586157 |
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| 520 | |a © 2024. The Author(s). | ||
| 520 | |a Impaired T-cell responses to mitogens and high T-cell activation marker (TAM) expression on Mycobacterium tuberculosis-specific T-cells characterize immunopathology in patients with tuberculosis (TB). In a study of patients with TB (n = 60) and asymptomatic contacts (controls, n = 37), we found that TB patients had higher CD38+ T-cell proportions specific for M. tuberculosis protein (PPDMtb), yet total proportions of PPDMtb-specific T-cells were comparable. Notably, both activated (CD38+) and total IFN-γ+ T-cells from TB patients had lower mitogen (phytohemagglutinin, PHA)-induced responses. This impaired mitogen response improved the classification efficacy of the TAM-TB assay, especially employing the PPD/PHA-induced T-cell ratio | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Immunopathology | |
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| 650 | 4 | |a T-cell activation marker | |
| 650 | 4 | |a Tuberculosis | |
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| 700 | 1 | |a Laing, Edwin F |e verfasserin |4 aut | |
| 700 | 1 | |a Frimpong, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Vivekanandan, Monika M |e verfasserin |4 aut | |
| 700 | 1 | |a Yeboah, Augustine |e verfasserin |4 aut | |
| 700 | 1 | |a Adankwah, Ernest |e verfasserin |4 aut | |
| 700 | 1 | |a Aniagyei, Wilfred |e verfasserin |4 aut | |
| 700 | 1 | |a Arthur, Joseph F |e verfasserin |4 aut | |
| 700 | 1 | |a Lamptey, Millicent |e verfasserin |4 aut | |
| 700 | 1 | |a Abass, Mohammed K |e verfasserin |4 aut | |
| 700 | 1 | |a Kumbel, Francis |e verfasserin |4 aut | |
| 700 | 1 | |a Osei-Yeboah, Francis |e verfasserin |4 aut | |
| 700 | 1 | |a Gawusu, Amidu |e verfasserin |4 aut | |
| 700 | 1 | |a Debrah, Linda Batsa |e verfasserin |4 aut | |
| 700 | 1 | |a Owusu, Dorcas O |e verfasserin |4 aut | |
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| 700 | 1 | |a Phillips, Richard O |e verfasserin |4 aut | |
| 700 | 1 | |a Jacobsen, Marc |e verfasserin |4 aut | |
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