Evaluation of the mannan antigen assay in neonates with or without Candida albicans colonization
© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology..
Mannan antigen (MA) in neonates as a marker of invasive candidemia is not well studied, although 4% of all neonatal intensive care unit admissions are attributed to Candida spp. infections. The aim of this case-control study was to evaluate the performance of MA (Platelia™ Candida AgPluskit, Bio-Rad) in neonates who had rectal Candida colonization or in non-colonized controls. We cultured 340 rectal swabs of neonates and MA was negative in 24/25 C. albicans colonized (96% specificity) and in 30/30 non-colonized neonates (100% specificity). The results indicate a high specificity of the assay, which could be useful in neonates with possible candidemia.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
Medical mycology - 62(2024), 2 vom: 27. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bourika, Vasiliki [VerfasserIn] |
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| Links: |
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| Themen: |
Antigens |
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| Anmerkungen: |
Date Completed 29.01.2024 Date Revised 29.01.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/mmy/myad138 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Mannan antigen (MA) in neonates as a marker of invasive candidemia is not well studied, although 4% of all neonatal intensive care unit admissions are attributed to Candida spp. infections. The aim of this case-control study was to evaluate the performance of MA (Platelia™ Candida AgPluskit, Bio-Rad) in neonates who had rectal Candida colonization or in non-colonized controls. We cultured 340 rectal swabs of neonates and MA was negative in 24/25 C. albicans colonized (96% specificity) and in 30/30 non-colonized neonates (100% specificity). The results indicate a high specificity of the assay, which could be useful in neonates with possible candidemia | ||
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