Ruthenium-Catalyzed Carbonylation of α-Aminoaryl-Tethered Alkylidenecyclopropanes : Synthesis of Eight-Membered Benzolactams
The synthesis of medium-sized lactams is a great challenge because of the unfavorable transannular interactions and entropic barriers in the transition state. We have developed a ruthenium-catalyzed carbonylation of α-aminoaryl-tethered alkylidenecyclopropanes (ACPs) that allows for the efficient preparation of valuable eight-membered benzolactams under ligand-free conditions. The amino group served a dual role of both directing group and nucleophile to facilitate the metallacycle formation and the carbonylation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Organic letters - 26(2024), 1 vom: 12. Jan., Seite 231-235 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ji, Miao-Miao [VerfasserIn] |
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| Anmerkungen: |
Date Revised 12.01.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.orglett.3c03913 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM36655767X |
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| 100 | 1 | |a Ji, Miao-Miao |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ruthenium-Catalyzed Carbonylation of α-Aminoaryl-Tethered Alkylidenecyclopropanes |b Synthesis of Eight-Membered Benzolactams |
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| 500 | |a Date Revised 12.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a The synthesis of medium-sized lactams is a great challenge because of the unfavorable transannular interactions and entropic barriers in the transition state. We have developed a ruthenium-catalyzed carbonylation of α-aminoaryl-tethered alkylidenecyclopropanes (ACPs) that allows for the efficient preparation of valuable eight-membered benzolactams under ligand-free conditions. The amino group served a dual role of both directing group and nucleophile to facilitate the metallacycle formation and the carbonylation | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Liu, Peng-Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Jun-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a He, Yong-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Hongguang |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Ai-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Jin-Bao |e verfasserin |4 aut | |
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