Impact of 2021 European Academy of Neurology/Peripheral Nerve Society diagnostic criteria on diagnosis and therapy of chronic inflammatory demyelinating polyradiculoneuropathy variants
© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology..
BACKGROUND AND PURPOSE: There are different criteria for the diagnosis of different variants of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The 2021 European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) guidelines provide specific clinical criteria for each CIDP variant even if their therapeutical impact has not been investigated.
METHODS: We applied the clinical criteria for CIDP variants of the 2021 EAN/PNS guidelines to 369 patients included in the Italian CIDP database who fulfilled the 2021 EAN/PNS electrodiagnostic criteria for CIDP.
RESULTS: According to the 2021 EAN/PNS clinical criteria, 245 patients achieved a clinical diagnosis of typical CIDP or CIDP variant (66%). We identified 106 patients with typical CIDP (29%), 62 distal CIDP (17%), 28 multifocal or focal CIDP (7%), four sensory CIDP (1%), 27 sensory-predominant CIDP (7%), 10 motor CIDP (3%), and eight motor-predominant CIDP (2%). Patients with multifocal, distal, and sensory CIDP had milder impairment and symptoms. Patients with multifocal CIDP had less frequently reduced conduction velocity and prolonged F-wave latency and had lower levels of cerebrospinal fluid protein. Patients with distal CIDP more frequently had reduced distal compound muscle action potentials. Patients with motor CIDP did not improve after steroid therapy, whereas those with motor-predominant CIDP did. None of the patients with sensory CIDP responded to steroids, whereas most of those with sensory-predominant CIDP did.
CONCLUSIONS: The 2021 EAN/PNS criteria for CIDP allow a better characterization of CIDP variants, permitting their distinction from typical CIDP and more appropriate treatment for patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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| Enthalten in: |
European journal of neurology - 31(2024), 4 vom: 13. März, Seite e16190 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
De Lorenzo, Alberto [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.03.2024 Date Revised 14.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/ene.16190 |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. | ||
| 520 | |a BACKGROUND AND PURPOSE: There are different criteria for the diagnosis of different variants of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The 2021 European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) guidelines provide specific clinical criteria for each CIDP variant even if their therapeutical impact has not been investigated | ||
| 520 | |a METHODS: We applied the clinical criteria for CIDP variants of the 2021 EAN/PNS guidelines to 369 patients included in the Italian CIDP database who fulfilled the 2021 EAN/PNS electrodiagnostic criteria for CIDP | ||
| 520 | |a RESULTS: According to the 2021 EAN/PNS clinical criteria, 245 patients achieved a clinical diagnosis of typical CIDP or CIDP variant (66%). We identified 106 patients with typical CIDP (29%), 62 distal CIDP (17%), 28 multifocal or focal CIDP (7%), four sensory CIDP (1%), 27 sensory-predominant CIDP (7%), 10 motor CIDP (3%), and eight motor-predominant CIDP (2%). Patients with multifocal, distal, and sensory CIDP had milder impairment and symptoms. Patients with multifocal CIDP had less frequently reduced conduction velocity and prolonged F-wave latency and had lower levels of cerebrospinal fluid protein. Patients with distal CIDP more frequently had reduced distal compound muscle action potentials. Patients with motor CIDP did not improve after steroid therapy, whereas those with motor-predominant CIDP did. None of the patients with sensory CIDP responded to steroids, whereas most of those with sensory-predominant CIDP did | ||
| 520 | |a CONCLUSIONS: The 2021 EAN/PNS criteria for CIDP allow a better characterization of CIDP variants, permitting their distinction from typical CIDP and more appropriate treatment for patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a European Academy of Neurology | |
| 650 | 4 | |a Lewis-Sumner syndrome | |
| 650 | 4 | |a Peripheral Nerve Society | |
| 650 | 4 | |a chronic inflammatory demyelinating polyradiculoneuropathy | |
| 650 | 4 | |a chronic inflammatory demyelinating polyradiculoneuropathy variants | |
| 650 | 4 | |a diagnostic criteria | |
| 650 | 4 | |a intravenous immunoglobulin | |
| 650 | 4 | |a steroids | |
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| 700 | 1 | |a Doneddu, Pietro Emiliano |e verfasserin |4 aut | |
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| 700 | 1 | |a Cocito, Dario |e verfasserin |4 aut | |
| 700 | 1 | |a Briani, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Fazio, Raffaella |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzeo, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Schenone, Angelo |e verfasserin |4 aut | |
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| 700 | 1 | |a Cosentino, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Marfia, Girolama Alessandra |e verfasserin |4 aut | |
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| 700 | 1 | |a Filosto, Massimiliano |e verfasserin |4 aut | |
| 700 | 1 | |a Antonini, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Clerici, Angelo Maurizio |e verfasserin |4 aut | |
| 700 | 1 | |a Luigetti, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Matà, Sabrina |e verfasserin |4 aut | |
| 700 | 1 | |a Rosso, Tiziana |e verfasserin |4 aut | |
| 700 | 1 | |a Lucchetta, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Siciliano, Gabriele |e verfasserin |4 aut | |
| 700 | 1 | |a Lauria Pinter, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Cavaletti, Guido |e verfasserin |4 aut | |
| 700 | 1 | |a Inghilleri, Maurizio |e verfasserin |4 aut | |
| 700 | 1 | |a Cantisani, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Notturno, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Ricciardi, Dario |e verfasserin |4 aut | |
| 700 | 1 | |a Habetswallner, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Spina, Emanuele |e verfasserin |4 aut | |
| 700 | 1 | |a Peci, Erdita |e verfasserin |4 aut | |
| 700 | 1 | |a Salvalaggio, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Falzone, Yuri |e verfasserin |4 aut | |
| 700 | 1 | |a Strano, Camilla |e verfasserin |4 aut | |
| 700 | 1 | |a Gentile, Luca |e verfasserin |4 aut | |
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| 700 | 0 | |a Italian CIDP Database Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Doneddu, Pietro Emiliano |e investigator |4 oth | |
| 700 | 1 | |a De Lorenzo, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Liberatore, Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a -Orazio, Eduardo Nobile |e investigator |4 oth | |
| 700 | 1 | |a Cocito, Dario |e investigator |4 oth | |
| 700 | 1 | |a Manganelli, Fiore |e investigator |4 oth | |
| 700 | 1 | |a Spina, Emanuele |e investigator |4 oth | |
| 700 | 1 | |a Pisano, Enrica |e investigator |4 oth | |
| 700 | 1 | |a Santoro, Lucio |e investigator |4 oth | |
| 700 | 1 | |a Velardo, Daniele |e investigator |4 oth | |
| 700 | 1 | |a Strano, Camilla |e investigator |4 oth | |
| 700 | 1 | |a Fazio, Raffaella |e investigator |4 oth | |
| 700 | 1 | |a Ruiz, Marta |e investigator |4 oth | |
| 700 | 1 | |a Cacciavillani, Mario |e investigator |4 oth | |
| 700 | 1 | |a Castellani, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Briani, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Caria, Filomena |e investigator |4 oth | |
| 700 | 1 | |a Filosto, Massimiliano |e investigator |4 oth | |
| 700 | 1 | |a Bianchi, Elisa |e investigator |4 oth | |
| 700 | 1 | |a Beghi, Ettore |e investigator |4 oth | |
| 700 | 1 | |a Verrengia, Elena Pinuccia |e investigator |4 oth | |
| 700 | 1 | |a Jann, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Toscano, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Gentile, Luca |e investigator |4 oth | |
| 700 | 1 | |a Russo, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Mazzeo, Anna |e investigator |4 oth | |
| 700 | 1 | |a Leonardi, Luca |e investigator |4 oth | |
| 700 | 1 | |a Antonini, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Cosentino, Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Callegari, Ilaria |e investigator |4 oth | |
| 700 | 1 | |a Cortese, Andrea |e investigator |4 oth | |
| 700 | 1 | |a Mataluni, Giorgia |e investigator |4 oth | |
| 700 | 1 | |a Marfia, Girolama Alessandra |e investigator |4 oth | |
| 700 | 1 | |a Clerici, Angelo Maurizio |e investigator |4 oth | |
| 700 | 1 | |a Scrascia, Federica |e investigator |4 oth | |
| 700 | 1 | |a Carpo, Marinella |e investigator |4 oth | |
| 700 | 1 | |a Schenone, Angelo |e investigator |4 oth | |
| 700 | 1 | |a Benedetti, Luana |e investigator |4 oth | |
| 700 | 1 | |a Cabona, Corrado |e investigator |4 oth | |
| 700 | 1 | |a Beronio, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Schirinzi, Erika |e investigator |4 oth | |
| 700 | 1 | |a Siciliano, Gabriele |e investigator |4 oth | |
| 700 | 1 | |a Luigetti, Marco |e investigator |4 oth | |
| 700 | 1 | |a Dacci, Patrizia |e investigator |4 oth | |
| 700 | 1 | |a Lauria, Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Rosso, Tiziana |e investigator |4 oth | |
| 700 | 1 | |a Balducci, Claudia |e investigator |4 oth | |
| 700 | 1 | |a Cavaletti, Guido |e investigator |4 oth | |
| 700 | 1 | |a Sabatelli, Mario |e investigator |4 oth | |
| 700 | 1 | |a Peci, Erdita |e investigator |4 oth | |
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