Modeling undetected poliovirus circulation following the 2022 outbreak in the United States
BACKGROUND: New York State (NYS) reported a polio case (June 2022) and outbreak of imported type 2 circulating vaccine-derived poliovirus (cVDPV2) (last positive wastewater detection in February 2023), for which uncertainty remains about potential ongoing undetected transmission.
RESEARCH DESIGN AND METHODS: Extending a prior deterministic model, we apply an established stochastic modeling approach to characterize the confidence about no circulation (CNC) of cVDPV2 as a function of time since the last detected signal of transmission (i.e. poliovirus positive acute flaccid myelitis case or wastewater sample).
RESULTS: With the surveillance coverage for the NYS population majority and its focus on outbreak counties, modeling suggests a high CNC (95%) within 3-10 months of the last positive surveillance signal, depending on surveillance sensitivity and population mixing patterns. Uncertainty about surveillance sensitivity implies longer durations required to achieve higher CNC.
CONCLUSIONS: In populations that maintain high overall immunization coverage with inactivated poliovirus vaccine (IPV), rare polio cases may occur in un(der)-vaccinated individuals. Modeling demonstrates the unlikeliness of type 2 outbreaks reestablishing endemic transmission or resulting in large absolute numbers of paralytic cases. Achieving and maintaining high immunization coverage with IPV remains the most effective measure to prevent outbreaks and shorten the duration of imported poliovirus transmission.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Expert review of vaccines - 23(2024), 1 vom: 23. Jan., Seite 186-195 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kalkowska, Dominika A [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 05.01.2024 Date Revised 25.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14760584.2023.2299401 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366553348 |
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| 100 | 1 | |a Kalkowska, Dominika A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Modeling undetected poliovirus circulation following the 2022 outbreak in the United States |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Completed 05.01.2024 | ||
| 500 | |a Date Revised 25.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: New York State (NYS) reported a polio case (June 2022) and outbreak of imported type 2 circulating vaccine-derived poliovirus (cVDPV2) (last positive wastewater detection in February 2023), for which uncertainty remains about potential ongoing undetected transmission | ||
| 520 | |a RESEARCH DESIGN AND METHODS: Extending a prior deterministic model, we apply an established stochastic modeling approach to characterize the confidence about no circulation (CNC) of cVDPV2 as a function of time since the last detected signal of transmission (i.e. poliovirus positive acute flaccid myelitis case or wastewater sample) | ||
| 520 | |a RESULTS: With the surveillance coverage for the NYS population majority and its focus on outbreak counties, modeling suggests a high CNC (95%) within 3-10 months of the last positive surveillance signal, depending on surveillance sensitivity and population mixing patterns. Uncertainty about surveillance sensitivity implies longer durations required to achieve higher CNC | ||
| 520 | |a CONCLUSIONS: In populations that maintain high overall immunization coverage with inactivated poliovirus vaccine (IPV), rare polio cases may occur in un(der)-vaccinated individuals. Modeling demonstrates the unlikeliness of type 2 outbreaks reestablishing endemic transmission or resulting in large absolute numbers of paralytic cases. Achieving and maintaining high immunization coverage with IPV remains the most effective measure to prevent outbreaks and shorten the duration of imported poliovirus transmission | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a IPV | |
| 650 | 4 | |a Polio | |
| 650 | 4 | |a dynamic modeling | |
| 650 | 4 | |a eradication | |
| 650 | 4 | |a outbreak response | |
| 650 | 7 | |a Poliovirus Vaccine, Oral |2 NLM | |
| 650 | 7 | |a Wastewater |2 NLM | |
| 650 | 7 | |a Poliovirus Vaccine, Inactivated |2 NLM | |
| 700 | 1 | |a Badizadegan, Kamran |e verfasserin |4 aut | |
| 700 | 1 | |a Routh, Janell A |e verfasserin |4 aut | |
| 700 | 1 | |a Burns, Cara C |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenberg, Eli S |e verfasserin |4 aut | |
| 700 | 1 | |a Brenner, I Ravi |e verfasserin |4 aut | |
| 700 | 1 | |a Zucker, Jane R |e verfasserin |4 aut | |
| 700 | 1 | |a Langdon-Embry, Marisa |e verfasserin |4 aut | |
| 700 | 1 | |a Thompson, Kimberly M |e verfasserin |4 aut | |
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