Antifungal efficacy of scorpion derived peptide K1K8 against Candida albicans in vitro and in vivo
Copyright © 2023 Elsevier Ltd. All rights reserved..
As an alternative class of antimicrobial agents, antimicrobial peptides (AMPs) have gained significant attention. In this study, K1K8, a scorpion AMP derivative, showed effective activity against Candida albicans including clinically resistant strains. K1K8 killed C. albicans cells mainly by damaging the cell membrane and inducing necrosis via an ROS-related pathway. K1K8 could also interact with DNA after damaging the nuclear envelope. Moreover, K1K8 inhibited hyphal development and biofilm formation of C. albicans in a dose-dependent manner. In the mouse skin infection model, K1K8 significantly decreased the counts of C. albicans cells in the infection area. Overall, K1K8 is a potential anti-infective agent against skin infections caused by C. albicans.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:238 |
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| Enthalten in: |
Toxicon : official journal of the International Society on Toxinology - 238(2024) vom: 01. Jan., Seite 107593 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shui, Yingbin [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Infective Agents |
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| Anmerkungen: |
Date Completed 22.01.2024 Date Revised 22.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.toxicon.2023.107593 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a As an alternative class of antimicrobial agents, antimicrobial peptides (AMPs) have gained significant attention. In this study, K1K8, a scorpion AMP derivative, showed effective activity against Candida albicans including clinically resistant strains. K1K8 killed C. albicans cells mainly by damaging the cell membrane and inducing necrosis via an ROS-related pathway. K1K8 could also interact with DNA after damaging the nuclear envelope. Moreover, K1K8 inhibited hyphal development and biofilm formation of C. albicans in a dose-dependent manner. In the mouse skin infection model, K1K8 significantly decreased the counts of C. albicans cells in the infection area. Overall, K1K8 is a potential anti-infective agent against skin infections caused by C. albicans | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Chen, Yunqi |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Yixuan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Shasha |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wenlu |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wanwu |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Pengfei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zhongjie |e verfasserin |4 aut | |
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