The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial
© 2023 The Authors..
Objective: Primary purpose was to examine the effects of exercise and use of a spinal orthosis on quality of life (QoL). Secondary, to explore the effects of above-mentioned interventions on plasma levels of potential markers of pain: substance P (SP), calcitonin gene-related peptide (CGRP), and interleukin-6 (IL-6).
Design: Randomized controlled trial.
Setting: Community-dwelling women in Stockholm.
Participants: A total of 113 women aged 60-93 years suffering from back pain and self-reported osteoporosis (n=113).
Interventions: The randomized controlled trial was 3-armed: participation in an equipment exercise group, treatment with an activating spinal orthosis or controls. The intervention time was 6 months.
Main Outcome Measures: QoL (QUALEFFO-41 and SF-36), plasma levels of SP, CGRP, and IL-6 measured at baseline and after 6 months in all 3 arms.
Results: No improvement of QoL was found. Comparing change in mobility (QUALEFFO-41), the effect in least squares means was lower in the spinal orthosis group compared with controls. In the exercise group, the role emotional score (SF-36) deteriorated during the intervention. Effect size varied between 0.02 and 0.6. There was no change in the levels of CGRP or SP, while IL-6 levels were lower at 6 months in the spinal orthosis group compared with the other groups. At least 1 previous vertebral fracture was verified by X-ray in 46 women.
Conclusion: The interventions showed none or negative effect on QoL, which was unexpected. The modest effect size may prompt a cautious interpretation. We found a lowering of IL-6 levels in the spinal orthosis group, but more studies are needed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Archives of rehabilitation research and clinical translation - 5(2023), 4 vom: 01. Dez., Seite 100297 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Uzunel, Elin [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarkers |
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| Anmerkungen: |
Date Revised 03.01.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.arrct.2023.100297 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36653680X |
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| 100 | 1 | |a Uzunel, Elin |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 03.01.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Authors. | ||
| 520 | |a Objective: Primary purpose was to examine the effects of exercise and use of a spinal orthosis on quality of life (QoL). Secondary, to explore the effects of above-mentioned interventions on plasma levels of potential markers of pain: substance P (SP), calcitonin gene-related peptide (CGRP), and interleukin-6 (IL-6) | ||
| 520 | |a Design: Randomized controlled trial | ||
| 520 | |a Setting: Community-dwelling women in Stockholm | ||
| 520 | |a Participants: A total of 113 women aged 60-93 years suffering from back pain and self-reported osteoporosis (n=113) | ||
| 520 | |a Interventions: The randomized controlled trial was 3-armed: participation in an equipment exercise group, treatment with an activating spinal orthosis or controls. The intervention time was 6 months | ||
| 520 | |a Main Outcome Measures: QoL (QUALEFFO-41 and SF-36), plasma levels of SP, CGRP, and IL-6 measured at baseline and after 6 months in all 3 arms | ||
| 520 | |a Results: No improvement of QoL was found. Comparing change in mobility (QUALEFFO-41), the effect in least squares means was lower in the spinal orthosis group compared with controls. In the exercise group, the role emotional score (SF-36) deteriorated during the intervention. Effect size varied between 0.02 and 0.6. There was no change in the levels of CGRP or SP, while IL-6 levels were lower at 6 months in the spinal orthosis group compared with the other groups. At least 1 previous vertebral fracture was verified by X-ray in 46 women | ||
| 520 | |a Conclusion: The interventions showed none or negative effect on QoL, which was unexpected. The modest effect size may prompt a cautious interpretation. We found a lowering of IL-6 levels in the spinal orthosis group, but more studies are needed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Osteoporosis | |
| 650 | 4 | |a Pain | |
| 650 | 4 | |a Quality of life | |
| 650 | 4 | |a Rehabilitation | |
| 650 | 4 | |a Women | |
| 700 | 1 | |a Kronhed, Ann-Charlotte Grahn |e verfasserin |4 aut | |
| 700 | 1 | |a Alin, Christina Kaijser |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmed, Aisha Siddiqah |e verfasserin |4 aut | |
| 700 | 1 | |a Wändell, Per |e verfasserin |4 aut | |
| 700 | 1 | |a Salminen, Helena |e verfasserin |4 aut | |
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