Impact of anticancer drugs on the therapeutic efficacy and side effects of hepatic arterial embolization for hepatocellular carcinoma
© 2023 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd..
Background and Aim: Transcatheter arterial chemoembolization (TACE) using various anticancer drugs is often performed to treat hepatocellular carcinoma (HCC). We aimed to compare the therapeutic efficacy and side effects of TACE with anticancer drugs versus transcatheter arterial embolization (TAE) without anticancer drugs for HCC.
Methods: Patients with HCC were randomized to either the TACE or TAE group. Up to five target nodules were treated in each patient. Lipiodol (Lp; 10 mL), contrast media (CM; 10 mL), epirubicin (40 mg), mitomycin C (10 mg), miliplatin (70 mg), and 1-2-mm 2-day soluble gelatin sponge particles (2D-SGS) were injected into the TACE group, whereas Lp (10 mL), CM (10 mL), and 2D-SGS were injected into the TAE group. Treatment effect (TE) of the target nodules was graded (TE1-TE4) and patient responses were assessed. Three months after treatment, blood tests were performed to compare tumor markers and adverse events.
Results: Fifty-four patients and 161 target nodules were included; 75 nodules in 28 patients were treated by TACE, and 86 nodules in 26 patients were treated by TAE. The number of nodules graded TE1, TE2, TE3, and TE4 was 1, 28, 7, and 39, respectively, in the TACE group and 2, 25, 7, and 52, respectively, in the TAE group. The response rates were 89% (25/28) and 73% (19/26) in the TACE and TAE groups, respectively. There were no significant differences in TE, response rates, or blood test results between the two groups.
Conclusion: In hepatic arterial embolization for HCC, anticancer drugs did not have any impact on the therapeutic efficacy or side effects at 3 months after embolization.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
JGH open : an open access journal of gastroenterology and hepatology - 7(2023), 12 vom: 26. Dez., Seite 884-888 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ihira, Hironobu [VerfasserIn] |
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| Links: |
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| Themen: |
Gelatin sponge |
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| Anmerkungen: |
Date Revised 03.01.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1002/jgh3.12997 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366534882 |
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| 100 | 1 | |a Ihira, Hironobu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of anticancer drugs on the therapeutic efficacy and side effects of hepatic arterial embolization for hepatocellular carcinoma |
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| 520 | |a © 2023 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. | ||
| 520 | |a Background and Aim: Transcatheter arterial chemoembolization (TACE) using various anticancer drugs is often performed to treat hepatocellular carcinoma (HCC). We aimed to compare the therapeutic efficacy and side effects of TACE with anticancer drugs versus transcatheter arterial embolization (TAE) without anticancer drugs for HCC | ||
| 520 | |a Methods: Patients with HCC were randomized to either the TACE or TAE group. Up to five target nodules were treated in each patient. Lipiodol (Lp; 10 mL), contrast media (CM; 10 mL), epirubicin (40 mg), mitomycin C (10 mg), miliplatin (70 mg), and 1-2-mm 2-day soluble gelatin sponge particles (2D-SGS) were injected into the TACE group, whereas Lp (10 mL), CM (10 mL), and 2D-SGS were injected into the TAE group. Treatment effect (TE) of the target nodules was graded (TE1-TE4) and patient responses were assessed. Three months after treatment, blood tests were performed to compare tumor markers and adverse events | ||
| 520 | |a Results: Fifty-four patients and 161 target nodules were included; 75 nodules in 28 patients were treated by TACE, and 86 nodules in 26 patients were treated by TAE. The number of nodules graded TE1, TE2, TE3, and TE4 was 1, 28, 7, and 39, respectively, in the TACE group and 2, 25, 7, and 52, respectively, in the TAE group. The response rates were 89% (25/28) and 73% (19/26) in the TACE and TAE groups, respectively. There were no significant differences in TE, response rates, or blood test results between the two groups | ||
| 520 | |a Conclusion: In hepatic arterial embolization for HCC, anticancer drugs did not have any impact on the therapeutic efficacy or side effects at 3 months after embolization | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a gelatin sponge | |
| 650 | 4 | |a therapeutic chemoembolization | |
| 650 | 4 | |a therapeutic embolization | |
| 700 | 1 | |a Sonomura, Tetsuo |e verfasserin |4 aut | |
| 700 | 1 | |a Makitani, Ayano |e verfasserin |4 aut | |
| 700 | 1 | |a Makitani, Kazuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Fukuda, Kodai |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Ryota |e verfasserin |4 aut | |
| 700 | 1 | |a Koyama, Takao |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Hirotatsu |e verfasserin |4 aut | |
| 700 | 1 | |a Wan, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Ueno, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ida, Yoshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kawai, Nobuyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Minamiguchi, Hiroki |e verfasserin |4 aut | |
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