Non-prescription drug-associated out-of-hospital cardiac arrest : Changes in incidence over time and the odds of receiving resuscitation
Copyright © 2023 Elsevier B.V. All rights reserved..
BACKGROUND: Multiple jurisdictions reported a significant increase in out-of-hospital cardiac arrest (OHCA) incidence over the past decade, however the reasons for this remain unclear. We investigated how drug-associated OHCA (DA-OHCA) contributed to overall OHCA incidence, and whether the likelihood of treatment by emergency medical services (EMS) was associated with DA-OHCA classification.
METHODS: Using a large provincial cardiac arrest registry, we included consecutive, non-traumatic adult OHCA from 2016-2022. We classified as drug-associated if there were historical accounts of non-prescription drug use within the preceding 24 hours or evidence of paraphernalia at the scene. We examined year-by-year trends in OHCA and DA-OHCA incidence. We also investigated the association between DA-OHCA and odds of EMS treatment using an adjusted logistic regression model.
RESULTS: Of 33,365 EMS-assessed cases, 1,985/18,591 (11%) of EMS-treated OHCA and 887/9,200 (9.6%) of EMS-untreated OHCA were DA-OHCA. Of EMS-treated DA-OHCA, the median age was 40 years (IQR 31-51), 1,059 (53%) had a known history of non-prescription drug use, and 570 (29%) were public-location. From 2016 to 2022, EMS-treated OHCA incidence increased from 60 to 79 per 100,000 person-years; EMS-treated DA-OHCA incidence increased from 3.7 to 9.1 per 100,000 person-years. The proportion of overall OHCA classified as DA-OHCA increased from 6.1% to 11.5%. DA-OHCA was associated with greater odds of EMS treatment (AOR 1.34; 95%CI 1.13-1.58).
CONCLUSION: Although EMS-treated DA-OHCA incidence increased by nearly three-fold, it comprised a minority of the overall OHCA increase during the study period. DA-OHCA was associated with an increased likelihood of EMS treatment.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:195 |
|---|---|
| Enthalten in: |
Resuscitation - 195(2024) vom: 29. Feb., Seite 110107 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mok, Valerie [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cardiac arrest |
|---|
| Anmerkungen: |
Date Completed 19.02.2024 Date Revised 19.02.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.resuscitation.2023.110107 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM366515470 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM366515470 | ||
| 003 | DE-627 | ||
| 005 | 20240219231945.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240108s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.resuscitation.2023.110107 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1299.xml |
| 035 | |a (DE-627)NLM366515470 | ||
| 035 | |a (NLM)38160902 | ||
| 035 | |a (PII)S0300-9572(23)00843-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mok, Valerie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Non-prescription drug-associated out-of-hospital cardiac arrest |b Changes in incidence over time and the odds of receiving resuscitation |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 19.02.2024 | ||
| 500 | |a Date Revised 19.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Multiple jurisdictions reported a significant increase in out-of-hospital cardiac arrest (OHCA) incidence over the past decade, however the reasons for this remain unclear. We investigated how drug-associated OHCA (DA-OHCA) contributed to overall OHCA incidence, and whether the likelihood of treatment by emergency medical services (EMS) was associated with DA-OHCA classification | ||
| 520 | |a METHODS: Using a large provincial cardiac arrest registry, we included consecutive, non-traumatic adult OHCA from 2016-2022. We classified as drug-associated if there were historical accounts of non-prescription drug use within the preceding 24 hours or evidence of paraphernalia at the scene. We examined year-by-year trends in OHCA and DA-OHCA incidence. We also investigated the association between DA-OHCA and odds of EMS treatment using an adjusted logistic regression model | ||
| 520 | |a RESULTS: Of 33,365 EMS-assessed cases, 1,985/18,591 (11%) of EMS-treated OHCA and 887/9,200 (9.6%) of EMS-untreated OHCA were DA-OHCA. Of EMS-treated DA-OHCA, the median age was 40 years (IQR 31-51), 1,059 (53%) had a known history of non-prescription drug use, and 570 (29%) were public-location. From 2016 to 2022, EMS-treated OHCA incidence increased from 60 to 79 per 100,000 person-years; EMS-treated DA-OHCA incidence increased from 3.7 to 9.1 per 100,000 person-years. The proportion of overall OHCA classified as DA-OHCA increased from 6.1% to 11.5%. DA-OHCA was associated with greater odds of EMS treatment (AOR 1.34; 95%CI 1.13-1.58) | ||
| 520 | |a CONCLUSION: Although EMS-treated DA-OHCA incidence increased by nearly three-fold, it comprised a minority of the overall OHCA increase during the study period. DA-OHCA was associated with an increased likelihood of EMS treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cardiac arrest | |
| 650 | 4 | |a Cardiopulmonary resuscitation | |
| 650 | 4 | |a Drug toxicity | |
| 650 | 4 | |a Out-of-hospital cardiac arrest | |
| 650 | 4 | |a Substance use disorder | |
| 700 | 1 | |a Brebner, Callahan |e verfasserin |4 aut | |
| 700 | 1 | |a Yap, Justin |e verfasserin |4 aut | |
| 700 | 1 | |a Asamoah-Boaheng, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Hutton, Jacob |e verfasserin |4 aut | |
| 700 | 1 | |a Haines, Morgan |e verfasserin |4 aut | |
| 700 | 1 | |a Scheuermeyer, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Kawano, Takahisa |e verfasserin |4 aut | |
| 700 | 1 | |a Christenson, Jim |e verfasserin |4 aut | |
| 700 | 1 | |a Grunau, Brian |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Resuscitation |d 1972 |g 195(2024) vom: 29. Feb., Seite 110107 |w (DE-627)NLM000010049 |x 1873-1570 |7 nnns |
| 773 | 1 | 8 | |g volume:195 |g year:2024 |g day:29 |g month:02 |g pages:110107 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.resuscitation.2023.110107 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 195 |j 2024 |b 29 |c 02 |h 110107 | ||