Is Kidney Function Associated with Age-Related Macular Degeneration? : Findings from the Asian Eye Epidemiology Consortium
Copyright © 2024 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved..
PURPOSE: Chronic kidney disease (CKD) may elevate susceptibility to age-related macular degeneration (AMD) because of shared risk factors, pathogenic mechanisms, and genetic polymorphisms. Given the inconclusive findings in prior studies, we investigated this association using extensive datasets in the Asian Eye Epidemiology Consortium.
DESIGN: Cross-sectional study.
PARTICIPANTS: Fifty-one thousand two hundred fifty-three participants from 10 distinct population-based Asian studies.
METHODS: Age-related macular degeneration was defined using the Wisconsin Age-Related Maculopathy Grading System, the International Age-Related Maculopathy Epidemiological Study Group Classification, or the Beckman Clinical Classification. Chronic kidney disease was defined as estimated glomerular filtration rate (eGFR) of less than 60 ml/min per 1.73 m2. A pooled analysis using individual-level participant data was performed to examine the associations between CKD and eGFR with AMD (early and late), adjusting for age, sex, hypertension, diabetes, body mass index, smoking status, total cholesterol, and study groups.
MAIN OUTCOME MEASURES: Odds ratio (OR) of early and late AMD.
RESULTS: Among 51 253 participants (mean age, 54.1 ± 14.5 years), 5079 had CKD (9.9%). The prevalence of early AMD was 9.0%, and that of late AMD was 0.71%. After adjusting for confounders, individuals with CKD were associated with higher odds of late AMD (OR, 1.46; 95% confidence interval [CI], 1.11-1.93; P = 0.008). Similarly, poorer kidney function (per 10-unit eGFR decrease) was associated with late AMD (OR, 1.12; 95% CI, 1.05-1.19; P = 0.001). Nevertheless, CKD and eGFR were not associated significantly with early AMD (all P ≥ 0.149).
CONCLUSIONS: Pooled analysis from 10 distinct Asian population-based studies revealed that CKD and compromised kidney function are associated significantly with late AMD. This finding further underscores the importance of ocular examinations in patients with CKD.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
|---|---|
| Enthalten in: |
Ophthalmology - (2023) vom: 29. Dez. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Xue, Can Can [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Age-related macular degeneration |
|---|
| Anmerkungen: |
Date Revised 28.02.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.ophtha.2023.12.030 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM366515233 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM366515233 | ||
| 003 | DE-627 | ||
| 005 | 20240229170609.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240108s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ophtha.2023.12.030 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1310.xml |
| 035 | |a (DE-627)NLM366515233 | ||
| 035 | |a (NLM)38160880 | ||
| 035 | |a (PII)S0161-6420(23)00937-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Xue, Can Can |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Is Kidney Function Associated with Age-Related Macular Degeneration? |b Findings from the Asian Eye Epidemiology Consortium |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 28.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a PURPOSE: Chronic kidney disease (CKD) may elevate susceptibility to age-related macular degeneration (AMD) because of shared risk factors, pathogenic mechanisms, and genetic polymorphisms. Given the inconclusive findings in prior studies, we investigated this association using extensive datasets in the Asian Eye Epidemiology Consortium | ||
| 520 | |a DESIGN: Cross-sectional study | ||
| 520 | |a PARTICIPANTS: Fifty-one thousand two hundred fifty-three participants from 10 distinct population-based Asian studies | ||
| 520 | |a METHODS: Age-related macular degeneration was defined using the Wisconsin Age-Related Maculopathy Grading System, the International Age-Related Maculopathy Epidemiological Study Group Classification, or the Beckman Clinical Classification. Chronic kidney disease was defined as estimated glomerular filtration rate (eGFR) of less than 60 ml/min per 1.73 m2. A pooled analysis using individual-level participant data was performed to examine the associations between CKD and eGFR with AMD (early and late), adjusting for age, sex, hypertension, diabetes, body mass index, smoking status, total cholesterol, and study groups | ||
| 520 | |a MAIN OUTCOME MEASURES: Odds ratio (OR) of early and late AMD | ||
| 520 | |a RESULTS: Among 51 253 participants (mean age, 54.1 ± 14.5 years), 5079 had CKD (9.9%). The prevalence of early AMD was 9.0%, and that of late AMD was 0.71%. After adjusting for confounders, individuals with CKD were associated with higher odds of late AMD (OR, 1.46; 95% confidence interval [CI], 1.11-1.93; P = 0.008). Similarly, poorer kidney function (per 10-unit eGFR decrease) was associated with late AMD (OR, 1.12; 95% CI, 1.05-1.19; P = 0.001). Nevertheless, CKD and eGFR were not associated significantly with early AMD (all P ≥ 0.149) | ||
| 520 | |a CONCLUSIONS: Pooled analysis from 10 distinct Asian population-based studies revealed that CKD and compromised kidney function are associated significantly with late AMD. This finding further underscores the importance of ocular examinations in patients with CKD | ||
| 520 | |a FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Age-related macular degeneration | |
| 650 | 4 | |a Chronic kidney disease | |
| 650 | 4 | |a Estimated glomerular filtration rate | |
| 700 | 1 | |a Sim, Ralene |e verfasserin |4 aut | |
| 700 | 1 | |a Chee, Miao Li |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ya Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Rim, Tyler Hyungtaek |e verfasserin |4 aut | |
| 700 | 1 | |a Hyung, Park Kyu |e verfasserin |4 aut | |
| 700 | 1 | |a Woong, Kang Se |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Su Jeong |e verfasserin |4 aut | |
| 700 | 1 | |a Nangia, Vinay |e verfasserin |4 aut | |
| 700 | 1 | |a Panda-Jonas, Songhomitra |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ning Li |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Sasaki, Mariko |e verfasserin |4 aut | |
| 700 | 1 | |a Harada, Sei |e verfasserin |4 aut | |
| 700 | 1 | |a Toru, Takebayashi |e verfasserin |4 aut | |
| 700 | 1 | |a Ryo, Kawasaki |e verfasserin |4 aut | |
| 700 | 1 | |a Raman, Rajiv |e verfasserin |4 aut | |
| 700 | 1 | |a Surya, Janani |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Rehana |e verfasserin |4 aut | |
| 700 | 1 | |a Bikbov, Mukharram |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Ian Y |e verfasserin |4 aut | |
| 700 | 1 | |a Cheung, Chui Ming Gemmy |e verfasserin |4 aut | |
| 700 | 1 | |a Jonas, Jost B |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Ching-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Tham, Yih-Chung |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Ophthalmology |d 1993 |g (2023) vom: 29. Dez. |w (DE-627)NLM000457019 |x 1549-4713 |7 nnns |
| 773 | 1 | 8 | |g year:2023 |g day:29 |g month:12 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ophtha.2023.12.030 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 29 |c 12 | ||