Mechanistic account of the left auditory cortex for tone-matching in schizophrenia : A pilot transcranial random noise stimulation (tRNS) sham-controlled study
Copyright © 2023 Elsevier B.V. All rights reserved..
OBJECTIVE: Deficits in the ability to match tones following brief delay and their contribution to higher-order cognitive alterations have been repeatedly documented in schizophrenia. The aim was to explore if left fronto-temporal high-frequency transcranial random noise stimulation (hf-tRNS), with electrodes placed over brain regions involved in tone-matching would significantly modulate performances in participants with schizophrenia.
METHODS: In a randomized, double-blind sham-controlled study, 10 participants with schizophrenia were allocated to receive ten sessions of either active or sham hf-tRNS. The anode was placed over the left prefrontal cortex and the cathode over the left temporoparietal junction. A tone-matching task was administered before and after the hf-tRNS.
RESULTS: We calculated the changes in tone-matching performance before and after hf-tRNS session in each group. A significant between-group difference was observed for the difficult tone-matching conditions (W= 14.500, p = 0.032), with tone-matching improvement in the sham group and no improvement in the active group.
DISCUSSION: hf-tRNS could disrupt the test-retest learning effect in the tone-matching task in individuals with schizophrenia. It is likely that this disruption resulted from cathodal-induced inhibition of the functional coupling between auditory cortical areas that correlates with tone-matching performance in patients.
CONCLUSION: The findings contribute to our understanding of hf-tRNS effects on early auditory processing in schizophrenia.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:92 |
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| Enthalten in: |
Asian journal of psychiatry - 92(2024) vom: 14. Feb., Seite 103879 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dondé, Clément [VerfasserIn] |
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| Links: |
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| Themen: |
Early auditory |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ajp.2023.103879 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366483552 |
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| 245 | 1 | 0 | |a Mechanistic account of the left auditory cortex for tone-matching in schizophrenia |b A pilot transcranial random noise stimulation (tRNS) sham-controlled study |
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| 500 | |a Date Revised 14.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVE: Deficits in the ability to match tones following brief delay and their contribution to higher-order cognitive alterations have been repeatedly documented in schizophrenia. The aim was to explore if left fronto-temporal high-frequency transcranial random noise stimulation (hf-tRNS), with electrodes placed over brain regions involved in tone-matching would significantly modulate performances in participants with schizophrenia | ||
| 520 | |a METHODS: In a randomized, double-blind sham-controlled study, 10 participants with schizophrenia were allocated to receive ten sessions of either active or sham hf-tRNS. The anode was placed over the left prefrontal cortex and the cathode over the left temporoparietal junction. A tone-matching task was administered before and after the hf-tRNS | ||
| 520 | |a RESULTS: We calculated the changes in tone-matching performance before and after hf-tRNS session in each group. A significant between-group difference was observed for the difficult tone-matching conditions (W= 14.500, p = 0.032), with tone-matching improvement in the sham group and no improvement in the active group | ||
| 520 | |a DISCUSSION: hf-tRNS could disrupt the test-retest learning effect in the tone-matching task in individuals with schizophrenia. It is likely that this disruption resulted from cathodal-induced inhibition of the functional coupling between auditory cortical areas that correlates with tone-matching performance in patients | ||
| 520 | |a CONCLUSION: The findings contribute to our understanding of hf-tRNS effects on early auditory processing in schizophrenia | ||
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Early auditory | |
| 650 | 4 | |a Non-invasive brain stimulation | |
| 650 | 4 | |a Schizophrenia | |
| 650 | 4 | |a Tone-matching | |
| 650 | 4 | |a Transcranial random noise stimulation | |
| 700 | 1 | |a Fivel, Laure |e verfasserin |4 aut | |
| 700 | 1 | |a Haesebaert, Fréderic |e verfasserin |4 aut | |
| 700 | 1 | |a Poulet, Emmanuel |e verfasserin |4 aut | |
| 700 | 1 | |a Mondino, Marine |e verfasserin |4 aut | |
| 700 | 1 | |a Brunelin, Jérôme |e verfasserin |4 aut | |
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