The combined treatment of gold nanoparticles associated with photobiomodulation accelerate the healing of dermonecrotic lesion
Introduction: The search for fast and efficient treatment for dermonecrotic lesions caused by the venom of the spider from the Loxosceles simillis, is a demand in health. Prednisolone is one of the most used drugs, however it has side effects. In this context, addictionally gold nanoparticles (GNPs) have anti-inflammatory, antioxidant, and antibacterial properties. The use of photobiomodulation has show to be efficient in the process of tissue repair. Therefore, the purpose of this study was to investigate the anti-inflammatory effect of photobiomodulation and GNPs associated or not with a low concentration of prednisolone in animal models of dermonecrotic lesion.Methodology: For this, rabbits with venon-induced dermonecrotic lesion were subjected to topical treatment with prednisolone + laser or GNPs + laser or Pred-GNPs + laser. The area of edema, necrosis and erythema were measured. On the last day of treatment, the animals were euthanized to remove the organs for histopathological and biochemical analysis.Results: All treatments combinations were effective in promoting the reduction of necrotic tissue and erythema.Conclusion: With this results, we suggest that the use of laser and nanoparticles, associated or not with prednisolone, should be considered for the treatment of dermonecrotic injury.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Journal of drug targeting - 32(2024), 2 vom: 01. Feb., Seite 172-185 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Oliveira, Daysiane [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.02.2024 Date Revised 02.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/1061186X.2023.2298848 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM366460684 |
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| 245 | 1 | 4 | |a The combined treatment of gold nanoparticles associated with photobiomodulation accelerate the healing of dermonecrotic lesion |
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| 520 | |a Introduction: The search for fast and efficient treatment for dermonecrotic lesions caused by the venom of the spider from the Loxosceles simillis, is a demand in health. Prednisolone is one of the most used drugs, however it has side effects. In this context, addictionally gold nanoparticles (GNPs) have anti-inflammatory, antioxidant, and antibacterial properties. The use of photobiomodulation has show to be efficient in the process of tissue repair. Therefore, the purpose of this study was to investigate the anti-inflammatory effect of photobiomodulation and GNPs associated or not with a low concentration of prednisolone in animal models of dermonecrotic lesion.Methodology: For this, rabbits with venon-induced dermonecrotic lesion were subjected to topical treatment with prednisolone + laser or GNPs + laser or Pred-GNPs + laser. The area of edema, necrosis and erythema were measured. On the last day of treatment, the animals were euthanized to remove the organs for histopathological and biochemical analysis.Results: All treatments combinations were effective in promoting the reduction of necrotic tissue and erythema.Conclusion: With this results, we suggest that the use of laser and nanoparticles, associated or not with prednisolone, should be considered for the treatment of dermonecrotic injury | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Gold nanoparticles | |
| 650 | 4 | |a dermonecrotic lesions | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a nanotechnology | |
| 650 | 4 | |a photobiomodulation | |
| 650 | 4 | |a tissue repair | |
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| 700 | 1 | |a Luiz, Gabriel Paulino |e verfasserin |4 aut | |
| 700 | 1 | |a Scussel, Rahisa |e verfasserin |4 aut | |
| 700 | 1 | |a Fagundes, Mirian Ivens |e verfasserin |4 aut | |
| 700 | 1 | |a Galvani, Nathália Coral |e verfasserin |4 aut | |
| 700 | 1 | |a Abel, Jessica da Silva |e verfasserin |4 aut | |
| 700 | 1 | |a Zaccaron, Rubya Pereira |e verfasserin |4 aut | |
| 700 | 1 | |a de Bem Silveira, Gustavo |e verfasserin |4 aut | |
| 700 | 1 | |a de Andrade, Thiago Antônio Moretti |e verfasserin |4 aut | |
| 700 | 1 | |a Lock Silveira, Paulo Cesar |e verfasserin |4 aut | |
| 700 | 1 | |a Andrez Machado-de-Ávila, Ricardo |e verfasserin |4 aut | |
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