Salvirrane A-F, six undescribed nordrimane sesquiterpene derivatives from Salvia castanea Diels f. tomentosa Stib and their cytotoxic activities
Copyright © 2023 Elsevier Ltd. All rights reserved..
Six undescribed nordrimane sesquiterpene derivatives, salvirrane A-F (1-6), were isolated from the roots and rhizomes of Salvia castanea Diels f. tomentosa Stib. Comprehensive spectral analysis and a quantum chemical calculation strategy were employed to determine their structures. These compounds represent four previously unreported nordrimane carbon skeletal types in Salvia genus, including 15-nor-drimane, 11,15-di-nor-drimane, 14,15-di-nor-drimane, and 11,14,15-tri-nor-drimane sesquiterpenes. All compounds were evaluated for their cytotoxic activities against several human cancer cell lines (A549, H460, Hep3B, MCF7, PC3, and HeLa). The results showed that 3 exhibited low activity against MCF7 cells (IC50,72.72 ± 6.95 μM) and moderate activity against HeLa cells (IC50, 9.80 ± 0.64 μM). Moreover, the EdU (5-ethynyl-2'-deoxyuridine) assay demonstrates that 3 displays dose-dependent efficacy in suppressing the proliferation of HeLa cells. Network pharmacology and molecular docking technology implied that 3 may potentially bind to Src (proto-oncogene tyrosine-protein kinase) to exert anti-proliferative activity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:218 |
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| Enthalten in: |
Phytochemistry - 218(2024) vom: 26. Jan., Seite 113958 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Rui [VerfasserIn] |
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| Links: |
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| Themen: |
Antineoplastic Agents |
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| Anmerkungen: |
Date Completed 15.01.2024 Date Revised 15.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.phytochem.2023.113958 |
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| 520 | |a Six undescribed nordrimane sesquiterpene derivatives, salvirrane A-F (1-6), were isolated from the roots and rhizomes of Salvia castanea Diels f. tomentosa Stib. Comprehensive spectral analysis and a quantum chemical calculation strategy were employed to determine their structures. These compounds represent four previously unreported nordrimane carbon skeletal types in Salvia genus, including 15-nor-drimane, 11,15-di-nor-drimane, 14,15-di-nor-drimane, and 11,14,15-tri-nor-drimane sesquiterpenes. All compounds were evaluated for their cytotoxic activities against several human cancer cell lines (A549, H460, Hep3B, MCF7, PC3, and HeLa). The results showed that 3 exhibited low activity against MCF7 cells (IC50,72.72 ± 6.95 μM) and moderate activity against HeLa cells (IC50, 9.80 ± 0.64 μM). Moreover, the EdU (5-ethynyl-2'-deoxyuridine) assay demonstrates that 3 displays dose-dependent efficacy in suppressing the proliferation of HeLa cells. Network pharmacology and molecular docking technology implied that 3 may potentially bind to Src (proto-oncogene tyrosine-protein kinase) to exert anti-proliferative activity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cytotoxic | |
| 650 | 4 | |a Lamiaceae | |
| 650 | 4 | |a Molecular docking | |
| 650 | 4 | |a Network pharmacology | |
| 650 | 4 | |a Nordrimane | |
| 650 | 4 | |a Salvia castanea | |
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| 700 | 1 | |a Wang, Dong-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Lian-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Ji, Peng-Xue |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xin-Min |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Zi-Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jue |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Jing-Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, An-Hua |e verfasserin |4 aut | |
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