Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved..
BACKGROUND: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma.
OBJECTIVE: To investigate the impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in adults with severe asthma.
METHODS: This was a longitudinal, cohort study across 22 countries participating in the International Severe Asthma Registry (https://isaregistries.org/) between May 2017 and January 2023. Change in 4 asthma domains (exacerbation rate, asthma control, long-term oral corticosteroid [LTOCS] dose, and lung function) was assessed from biologic initiation to 1 year post-treatment (minimum 24 weeks). Pre- to post-biologic changes for responders and nonresponders were described along a categorical gradient for each domain derived from pre-biologic distributions (exacerbation rate: 0 to 6+/y; asthma control: well controlled to uncontrolled; LTOCS: 0 to >30 mg/d; percent-predicted forced expiratory volume in 1 second [ppFEV1]: <50% to ≥80%).
RESULTS: Percentage of biologic responders (ie, those with a category improvement pre- to post-biologic) varied by domain and increased with greater pre-biologic impairment, increasing from 70.2% to 90.0% for exacerbation rate, 46.3% to 52.3% for asthma control, 31.1% to 58.5% for LTOCS daily dose, and 35.8% to 50.6% for ppFEV1. The proportion of patients having improvement post-biologic tended to be greater for anti-IL-5/5R compared with for anti-IgE for exacerbation, asthma control, and ppFEV1 domains, irrespective of pre-biologic impairment.
CONCLUSION: Our results provide realistic outcome-specific post-biologic expectations for both physicians and patients, will be foundational to inform future work on a multidimensional approach to define and assess biologic responders and response, and may enhance appropriate patient selection for biologic therapies.
TRIAL REGISTRATION: The ISAR database has ethical approval from the Anonymous Data Ethics Protocols and Transparency (ADEPT) committee (ADEPT0218) and is registered with the European Union Electronic Register of Post-Authorization studies (ENCEPP/DSPP/23720). The study was designed, implemented, and reported in compliance with the European Network Centres for Pharmacoepidemiology and Pharmacovigilance (ENCEPP) Code of Conduct (EUPAS38288) and with all applicable local and international laws and regulation, and registered with ENCEPP (https://www.encepp.eu/encepp/viewResource.htm?id=38289). Governance was provided by ADEPT (registration number: ADEPT1220).
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
|---|---|
| Enthalten in: |
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - (2023) vom: 25. Dez. |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 20.01.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.anai.2023.12.023 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM366417533 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM366417533 | ||
| 003 | DE-627 | ||
| 005 | 20240120231847.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231229s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.anai.2023.12.023 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1265.xml |
| 035 | |a (DE-627)NLM366417533 | ||
| 035 | |a (NLM)38151100 | ||
| 035 | |a (PII)S1081-1206(23)01508-9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Perez-de-Llano, Luis |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 20.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma | ||
| 520 | |a OBJECTIVE: To investigate the impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in adults with severe asthma | ||
| 520 | |a METHODS: This was a longitudinal, cohort study across 22 countries participating in the International Severe Asthma Registry (https://isaregistries.org/) between May 2017 and January 2023. Change in 4 asthma domains (exacerbation rate, asthma control, long-term oral corticosteroid [LTOCS] dose, and lung function) was assessed from biologic initiation to 1 year post-treatment (minimum 24 weeks). Pre- to post-biologic changes for responders and nonresponders were described along a categorical gradient for each domain derived from pre-biologic distributions (exacerbation rate: 0 to 6+/y; asthma control: well controlled to uncontrolled; LTOCS: 0 to >30 mg/d; percent-predicted forced expiratory volume in 1 second [ppFEV1]: <50% to ≥80%) | ||
| 520 | |a RESULTS: Percentage of biologic responders (ie, those with a category improvement pre- to post-biologic) varied by domain and increased with greater pre-biologic impairment, increasing from 70.2% to 90.0% for exacerbation rate, 46.3% to 52.3% for asthma control, 31.1% to 58.5% for LTOCS daily dose, and 35.8% to 50.6% for ppFEV1. The proportion of patients having improvement post-biologic tended to be greater for anti-IL-5/5R compared with for anti-IgE for exacerbation, asthma control, and ppFEV1 domains, irrespective of pre-biologic impairment | ||
| 520 | |a CONCLUSION: Our results provide realistic outcome-specific post-biologic expectations for both physicians and patients, will be foundational to inform future work on a multidimensional approach to define and assess biologic responders and response, and may enhance appropriate patient selection for biologic therapies | ||
| 520 | |a TRIAL REGISTRATION: The ISAR database has ethical approval from the Anonymous Data Ethics Protocols and Transparency (ADEPT) committee (ADEPT0218) and is registered with the European Union Electronic Register of Post-Authorization studies (ENCEPP/DSPP/23720). The study was designed, implemented, and reported in compliance with the European Network Centres for Pharmacoepidemiology and Pharmacovigilance (ENCEPP) Code of Conduct (EUPAS38288) and with all applicable local and international laws and regulation, and registered with ENCEPP (https://www.encepp.eu/encepp/viewResource.htm?id=38289). Governance was provided by ADEPT (registration number: ADEPT1220) | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Scelo, Ghislaine |e verfasserin |4 aut | |
| 700 | 1 | |a Canonica, G Walter |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Wenjia |e verfasserin |4 aut | |
| 700 | 1 | |a Henley, William |e verfasserin |4 aut | |
| 700 | 1 | |a Larenas-Linnemann, Désirée |e verfasserin |4 aut | |
| 700 | 1 | |a Peters, Matthew J |e verfasserin |4 aut | |
| 700 | 1 | |a Pfeffer, Paul E |e verfasserin |4 aut | |
| 700 | 1 | |a Tran, Trung N |e verfasserin |4 aut | |
| 700 | 1 | |a Ulrik, Charlotte Suppli |e verfasserin |4 aut | |
| 700 | 1 | |a Popov, Todor A |e verfasserin |4 aut | |
| 700 | 1 | |a Sadatsafavi, Mohsen |e verfasserin |4 aut | |
| 700 | 1 | |a Hew, Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Máspero, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Gibson, Peter G |e verfasserin |4 aut | |
| 700 | 1 | |a Christoff, George C |e verfasserin |4 aut | |
| 700 | 1 | |a Fitzgerald, J Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Torres-Duque, Carlos A |e verfasserin |4 aut | |
| 700 | 1 | |a Porsbjerg, Celeste M |e verfasserin |4 aut | |
| 700 | 1 | |a Papadopoulos, Nikolaos G |e verfasserin |4 aut | |
| 700 | 1 | |a Papaioannou, Andriana I |e verfasserin |4 aut | |
| 700 | 1 | |a Heffler, Enrico |e verfasserin |4 aut | |
| 700 | 1 | |a Iwanaga, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Ahmad, Mona |e verfasserin |4 aut | |
| 700 | 1 | |a Kuna, Piotr |e verfasserin |4 aut | |
| 700 | 1 | |a Fonseca, João A |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Lehebi, Riyad |e verfasserin |4 aut | |
| 700 | 1 | |a Rhee, Chin Kook |e verfasserin |4 aut | |
| 700 | 1 | |a Koh, Mariko Siyue |e verfasserin |4 aut | |
| 700 | 1 | |a Cosio, Borja G |e verfasserin |4 aut | |
| 700 | 1 | |a Perng Steve, Diahn-Warng |e verfasserin |4 aut | |
| 700 | 1 | |a Mahboub, Bassam |e verfasserin |4 aut | |
| 700 | 1 | |a Menzies-Gow, Andrew N |e verfasserin |4 aut | |
| 700 | 1 | |a Jackson, David J |e verfasserin |4 aut | |
| 700 | 1 | |a Busby, John |e verfasserin |4 aut | |
| 700 | 1 | |a Heaney, Liam G |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Pujan H |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Eileen |e verfasserin |4 aut | |
| 700 | 1 | |a Wechsler, Michael E |e verfasserin |4 aut | |
| 700 | 1 | |a Altraja, Alan |e verfasserin |4 aut | |
| 700 | 1 | |a Lehtimäki, Lauri |e verfasserin |4 aut | |
| 700 | 1 | |a Bourdin, Arnaud |e verfasserin |4 aut | |
| 700 | 1 | |a Bjermer, Leif |e verfasserin |4 aut | |
| 700 | 1 | |a Bulathsinhala, Lakmini |e verfasserin |4 aut | |
| 700 | 1 | |a Carter, Victoria |e verfasserin |4 aut | |
| 700 | 1 | |a Murray, Ruth |e verfasserin |4 aut | |
| 700 | 1 | |a Beastall, Aaron |e verfasserin |4 aut | |
| 700 | 1 | |a Denton, Eve |e verfasserin |4 aut | |
| 700 | 1 | |a Price, David B |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology |d 1995 |g (2023) vom: 25. Dez. |w (DE-627)NLM075127695 |x 1534-4436 |7 nnns |
| 773 | 1 | 8 | |g year:2023 |g day:25 |g month:12 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.anai.2023.12.023 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 25 |c 12 | ||