Virucidal effect of mouthwash on acyclovir-resistant herpes simplex virus
© 2023 Wiley Periodicals LLC..
OBJECTIVES: The symptoms of herpes simplex viruses type 1 (HSV-1) infections might be severe and persistent in immunocompromised patients in whom they reactivate at a high frequency. The development of Acyclovir (ACV) resistant strains due to long-term treatment with antiviral agents in those patients is not uncommon. The aim of the present study was to assess the virucidal effect of commercially available mouthwashes against ACV-resistant HSV-1 strains.
MATERIALS AND METHODS: Two acyclovir-resistant HSV-1 strains were exposed for 30 s to essential oil-based (Listerine Fresh Burst® and Listerine Zero®), chlorhexidine gluconate 0.2% (Hexidyl®) and povidone-iodine 7.5% (Betadine Gargle®) mouthwashes. Loss of virus infectivity was determined by means of plaque reduction assays in a cell culture system.
RESULTS: All 4 of the tested solutions significantly reduced virus infectivity, with the essential oil-based and povidone-iodine mouthwashes being slightly more efficacious, compared to chlorhexidine.
CONCLUSION: The findings of this analysis revealed that the tested oral rinses demonstrated in-vitro antiviral activity against ACV-resistant HSV. Comparative clinical trials are required to establish the clinical effectiveness of daily use of oral rinses in reducing the appearance of oral HSV lesions in immunocompromised patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Oral diseases - (2023) vom: 27. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bar Ilan, M [VerfasserIn] |
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| Links: |
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| Themen: |
Acyclovir |
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| Anmerkungen: |
Date Revised 27.12.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1111/odi.14843 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36641691X |
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| 245 | 1 | 0 | |a Virucidal effect of mouthwash on acyclovir-resistant herpes simplex virus |
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| 500 | |a Date Revised 27.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2023 Wiley Periodicals LLC. | ||
| 520 | |a OBJECTIVES: The symptoms of herpes simplex viruses type 1 (HSV-1) infections might be severe and persistent in immunocompromised patients in whom they reactivate at a high frequency. The development of Acyclovir (ACV) resistant strains due to long-term treatment with antiviral agents in those patients is not uncommon. The aim of the present study was to assess the virucidal effect of commercially available mouthwashes against ACV-resistant HSV-1 strains | ||
| 520 | |a MATERIALS AND METHODS: Two acyclovir-resistant HSV-1 strains were exposed for 30 s to essential oil-based (Listerine Fresh Burst® and Listerine Zero®), chlorhexidine gluconate 0.2% (Hexidyl®) and povidone-iodine 7.5% (Betadine Gargle®) mouthwashes. Loss of virus infectivity was determined by means of plaque reduction assays in a cell culture system | ||
| 520 | |a RESULTS: All 4 of the tested solutions significantly reduced virus infectivity, with the essential oil-based and povidone-iodine mouthwashes being slightly more efficacious, compared to chlorhexidine | ||
| 520 | |a CONCLUSION: The findings of this analysis revealed that the tested oral rinses demonstrated in-vitro antiviral activity against ACV-resistant HSV. Comparative clinical trials are required to establish the clinical effectiveness of daily use of oral rinses in reducing the appearance of oral HSV lesions in immunocompromised patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a acyclovir | |
| 650 | 4 | |a chlorhexidine | |
| 650 | 4 | |a essential oils-based mouthwashes | |
| 650 | 4 | |a herpes simplex virus | |
| 650 | 4 | |a povidone-iodine | |
| 650 | 4 | |a resistant | |
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| 700 | 1 | |a Cohen, R |e verfasserin |4 aut | |
| 700 | 1 | |a Georgaki, M |e verfasserin |4 aut | |
| 700 | 1 | |a Papadopoulou, E |e verfasserin |4 aut | |
| 700 | 1 | |a Nikitakis, N G |e verfasserin |4 aut | |
| 700 | 1 | |a Yarom, N |e verfasserin |4 aut | |
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