Predictive role of monocyte count for significant coronary artery disease identification in patients with stable coronary artery disease
BACKGROUND: The coronary artery disease (CAD) remains the leading cause of morbidity that is characterized by broad spectrum of symptoms. Up to 30% of performed angiographies reveal normal coronary arteries. The aim of the study was to find simple predictor for significant epicardial artery stenosis among patients with chronic coronary syndrome.
METHODS: There were 187 patients (131 (709%) men and 56 (30%) women) in the median (Q1-Q3) age of 67 [58-72] presenting with stable CAD symptoms enrolled into the present retrospective analysis. The demographical, clinical and laboratory characteristics between patients with normal and significant coronary artery stenosis were compared.
RESULTS: The multivariable analysis revealed coexistence of hypercholesterolemia as significant differentiation factor (odds ratio [OR]: 4.38, 95% confidence interval [CI]: 1.78-10.80, p = 0.001) for significant CAD and inverse relation to serum high density lipoprotein (OR: 0.19, 95% CI: 0.05-0.72, p = 0.015) and relation to creatinine concentration (OR: 1.03, 95% CI: 1.00-1.05, p = 0.012). Among whole peripheral blood count analysis, the significant relation was noticed to be hemoglobin concentration (OR: 1.09, 95% CI: 1.10-1.18, p = 0.022) and monocyte count (OR: 32.3, 95% CI: 1.09-653.6, p = 0.017). Receiver operator curve revealed (AUC: 0.641, p = 0.001) with the optimal cut-off value above 0.45 K/uL for monocyte, yelding sensitivity of 81.82% and specificity of 58.06%.
CONCLUSIONS: The peripheral monocyte count above 0.45 k/uL may be considered as a predictor of significant coronary artery disease in symptomatic patients with chronic coronary syndrome.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Cardiology journal - (2023) vom: 27. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Urbanowicz, Tomasz [VerfasserIn] |
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| Links: |
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| Themen: |
Angina |
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| Anmerkungen: |
Date Revised 27.12.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.5603/cj.95131 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366401483 |
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| 100 | 1 | |a Urbanowicz, Tomasz |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Predictive role of monocyte count for significant coronary artery disease identification in patients with stable coronary artery disease |
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| 500 | |a Date Revised 27.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a BACKGROUND: The coronary artery disease (CAD) remains the leading cause of morbidity that is characterized by broad spectrum of symptoms. Up to 30% of performed angiographies reveal normal coronary arteries. The aim of the study was to find simple predictor for significant epicardial artery stenosis among patients with chronic coronary syndrome | ||
| 520 | |a METHODS: There were 187 patients (131 (709%) men and 56 (30%) women) in the median (Q1-Q3) age of 67 [58-72] presenting with stable CAD symptoms enrolled into the present retrospective analysis. The demographical, clinical and laboratory characteristics between patients with normal and significant coronary artery stenosis were compared | ||
| 520 | |a RESULTS: The multivariable analysis revealed coexistence of hypercholesterolemia as significant differentiation factor (odds ratio [OR]: 4.38, 95% confidence interval [CI]: 1.78-10.80, p = 0.001) for significant CAD and inverse relation to serum high density lipoprotein (OR: 0.19, 95% CI: 0.05-0.72, p = 0.015) and relation to creatinine concentration (OR: 1.03, 95% CI: 1.00-1.05, p = 0.012). Among whole peripheral blood count analysis, the significant relation was noticed to be hemoglobin concentration (OR: 1.09, 95% CI: 1.10-1.18, p = 0.022) and monocyte count (OR: 32.3, 95% CI: 1.09-653.6, p = 0.017). Receiver operator curve revealed (AUC: 0.641, p = 0.001) with the optimal cut-off value above 0.45 K/uL for monocyte, yelding sensitivity of 81.82% and specificity of 58.06% | ||
| 520 | |a CONCLUSIONS: The peripheral monocyte count above 0.45 k/uL may be considered as a predictor of significant coronary artery disease in symptomatic patients with chronic coronary syndrome | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a angina | |
| 650 | 4 | |a atherosclerosis | |
| 650 | 4 | |a coronary artery disease | |
| 650 | 4 | |a monocyte | |
| 650 | 4 | |a significant stenosis | |
| 700 | 1 | |a Olasińska-Wiśniewska, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Michalak, Michał |e verfasserin |4 aut | |
| 700 | 1 | |a Komosa, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Filipiak, Krzysztof J |e verfasserin |4 aut | |
| 700 | 1 | |a Uruski, Paweł |e verfasserin |4 aut | |
| 700 | 1 | |a Radziemski, Artur |e verfasserin |4 aut | |
| 700 | 1 | |a Tykarski, Andrzej |e verfasserin |4 aut | |
| 700 | 1 | |a Jemielity, Marek |e verfasserin |4 aut | |
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