Factors associated with in-hospital and outpatient survival of patients with different types of stage IV cancer and venous thromboembolism
OBJECTIVE: To identify factors associated with in-hospital and outpatient survival of patients with different types of stage IV cancer who present with venous thromboembolic disease (VTE).
METHODS: In this prospective cohort, in-hospital and outpatient survival rates up to 180 days were analyzed using Kaplan-Meier curves. Cox regression was used to identify factors associated with different survival functions.
RESULTS: One hundred patients were analyzed (median age, 67.5 years; 75% with Charlson index of <10; 69% with Eastern Cooperative Oncology Group (ECOG) score of 3-4). In-hospital mortality was 18%, and the median time from admission to death was 11 days (interquartile range, 1-61 days). Factors significantly associated with in-hospital mortality were the ECOG score and thrombocytopenia. The 180-day mortality rate was 52%, with deaths mainly occurring in the first 90 days since VTE diagnosis. Additional factors significantly associated with outpatient mortality included male sex and neoplasms with a high risk of thrombosis (lung, pancreas, stomach, uterus, bladder, and kidney neoplasms).
CONCLUSION: Patients with stage IV cancer and acute VTE have short survival. Poor prognostic factors are thrombocytopenia, the ECOG score, and certain types of cancer. These results may help physicians individualize decisions regarding initiation and continuation of anticoagulant therapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
The Journal of international medical research - 51(2023), 12 vom: 26. Dez., Seite 3000605231219170 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Reyes, Edgar Julián [VerfasserIn] |
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| Links: |
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| Themen: |
Anticoagulants |
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| Anmerkungen: |
Date Completed 28.12.2023 Date Revised 29.12.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1177/03000605231219170 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366383175 |
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| 100 | 1 | |a Reyes, Edgar Julián |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Factors associated with in-hospital and outpatient survival of patients with different types of stage IV cancer and venous thromboembolism |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 28.12.2023 | ||
| 500 | |a Date Revised 29.12.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To identify factors associated with in-hospital and outpatient survival of patients with different types of stage IV cancer who present with venous thromboembolic disease (VTE) | ||
| 520 | |a METHODS: In this prospective cohort, in-hospital and outpatient survival rates up to 180 days were analyzed using Kaplan-Meier curves. Cox regression was used to identify factors associated with different survival functions | ||
| 520 | |a RESULTS: One hundred patients were analyzed (median age, 67.5 years; 75% with Charlson index of <10; 69% with Eastern Cooperative Oncology Group (ECOG) score of 3-4). In-hospital mortality was 18%, and the median time from admission to death was 11 days (interquartile range, 1-61 days). Factors significantly associated with in-hospital mortality were the ECOG score and thrombocytopenia. The 180-day mortality rate was 52%, with deaths mainly occurring in the first 90 days since VTE diagnosis. Additional factors significantly associated with outpatient mortality included male sex and neoplasms with a high risk of thrombosis (lung, pancreas, stomach, uterus, bladder, and kidney neoplasms) | ||
| 520 | |a CONCLUSION: Patients with stage IV cancer and acute VTE have short survival. Poor prognostic factors are thrombocytopenia, the ECOG score, and certain types of cancer. These results may help physicians individualize decisions regarding initiation and continuation of anticoagulant therapy | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a in-hospital survival | |
| 650 | 4 | |a outpatient survival | |
| 650 | 4 | |a prognostic factors | |
| 650 | 4 | |a venous thromboembolism | |
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| 700 | 1 | |a Ruiz-Talero, Paula |e verfasserin |4 aut | |
| 700 | 1 | |a Arenas, Mayra Alejandra |e verfasserin |4 aut | |
| 700 | 1 | |a Hernández-Flórez, Catalina |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz, Oscar M |e verfasserin |4 aut | |
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