AIM2 inflammasome : A potential therapeutic target in ischemic stroke
Copyright © 2023 Elsevier Inc. All rights reserved..
Ischemic stroke (IS) is a significant global public health issue with a high incidence, disability, and mortality rate. A robust inflammatory cascade with complex and wide-ranging mechanisms occurs following ischemic brain injury. Inflammasomes are multiprotein complexes in the cytoplasm that modulate the inflammatory response by releasing pro-inflammatory cytokines and inducing cellular pyroptosis. Among these inflammasomes, the Absent in Melanoma 2 (AIM2) inflammasome shows the ability to detect a wide range of pathogen DNAs, thereby triggering an inflammatory response. Recent studies have indicated that the aberrant expression of AIM2 inflammasome in various cells is closely associated with the pathological processes of ischemic brain injury. This paper summarizes the expression and regulatory role of AIM2 in CNS and peripheral immune cells and discusses current therapeutic approaches targeting AIM2 inflammasome. These findings aim to serve as a reference for future research in this field.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:259 |
|---|---|
| Enthalten in: |
Clinical immunology (Orlando, Fla.) - 259(2024) vom: 29. Feb., Seite 109881 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Fu, Rong [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
AIM2 inflammasome |
|---|
| Anmerkungen: |
Date Completed 29.01.2024 Date Revised 10.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.clim.2023.109881 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM366335634 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM366335634 | ||
| 003 | DE-627 | ||
| 005 | 20240410232345.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231227s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.clim.2023.109881 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1371.xml |
| 035 | |a (DE-627)NLM366335634 | ||
| 035 | |a (NLM)38142900 | ||
| 035 | |a (PII)S1521-6616(23)00645-9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Fu, Rong |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a AIM2 inflammasome |b A potential therapeutic target in ischemic stroke |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 29.01.2024 | ||
| 500 | |a Date Revised 10.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a Ischemic stroke (IS) is a significant global public health issue with a high incidence, disability, and mortality rate. A robust inflammatory cascade with complex and wide-ranging mechanisms occurs following ischemic brain injury. Inflammasomes are multiprotein complexes in the cytoplasm that modulate the inflammatory response by releasing pro-inflammatory cytokines and inducing cellular pyroptosis. Among these inflammasomes, the Absent in Melanoma 2 (AIM2) inflammasome shows the ability to detect a wide range of pathogen DNAs, thereby triggering an inflammatory response. Recent studies have indicated that the aberrant expression of AIM2 inflammasome in various cells is closely associated with the pathological processes of ischemic brain injury. This paper summarizes the expression and regulatory role of AIM2 in CNS and peripheral immune cells and discusses current therapeutic approaches targeting AIM2 inflammasome. These findings aim to serve as a reference for future research in this field | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a AIM2 inflammasome | |
| 650 | 4 | |a Inflammatory response | |
| 650 | 4 | |a Ischemic stroke | |
| 650 | 4 | |a Pyroptosis | |
| 650 | 7 | |a Inflammasomes |2 NLM | |
| 650 | 7 | |a AIM2 protein, human |2 NLM | |
| 650 | 7 | |a DNA-Binding Proteins |2 NLM | |
| 700 | 1 | |a Zhao, Linna |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Yuying |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Xiaoli |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Wenzhe |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Xueqi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yunsha |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Shixin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical immunology (Orlando, Fla.) |d 1999 |g 259(2024) vom: 29. Feb., Seite 109881 |w (DE-627)NLM098196855 |x 1521-7035 |7 nnns |
| 773 | 1 | 8 | |g volume:259 |g year:2024 |g day:29 |g month:02 |g pages:109881 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.clim.2023.109881 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 259 |j 2024 |b 29 |c 02 |h 109881 | ||