Profiling the dysregulated immune response in sepsis : overcoming challenges to achieve the goal of precision medicine
Copyright © 2024 Elsevier Ltd. All rights reserved..
Sepsis is characterised by a dysregulated host immune response to infection. Despite recognition of its significance, immune status monitoring is not implemented in clinical practice due in part to the current absence of direct therapeutic implications. Technological advances in immunological profiling could enhance our understanding of immune dysregulation and facilitate integration into clinical practice. In this Review, we provide an overview of the current state of immune profiling in sepsis, including its use, current challenges, and opportunities for progress. We highlight the important role of immunological biomarkers in facilitating predictive enrichment in current and future treatment scenarios. We propose that multiple immune and non-immune-related parameters, including clinical and microbiological data, be integrated into diagnostic and predictive combitypes, with the aid of machine learning and artificial intelligence techniques. These combitypes could form the basis of workable algorithms to guide clinical decisions that make precision medicine in sepsis a reality and improve patient outcomes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
The Lancet. Respiratory medicine - 12(2024), 4 vom: 29. Apr., Seite 305-322 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Cajander, Sara [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 01.04.2024 Date Revised 01.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/S2213-2600(23)00330-2 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM36633364X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM36633364X | ||
| 003 | DE-627 | ||
| 005 | 20240401232456.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231227s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/S2213-2600(23)00330-2 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1359.xml |
| 035 | |a (DE-627)NLM36633364X | ||
| 035 | |a (NLM)38142698 | ||
| 035 | |a (PII)S2213-2600(23)00330-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Cajander, Sara |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Profiling the dysregulated immune response in sepsis |b overcoming challenges to achieve the goal of precision medicine |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 01.04.2024 | ||
| 500 | |a Date Revised 01.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Sepsis is characterised by a dysregulated host immune response to infection. Despite recognition of its significance, immune status monitoring is not implemented in clinical practice due in part to the current absence of direct therapeutic implications. Technological advances in immunological profiling could enhance our understanding of immune dysregulation and facilitate integration into clinical practice. In this Review, we provide an overview of the current state of immune profiling in sepsis, including its use, current challenges, and opportunities for progress. We highlight the important role of immunological biomarkers in facilitating predictive enrichment in current and future treatment scenarios. We propose that multiple immune and non-immune-related parameters, including clinical and microbiological data, be integrated into diagnostic and predictive combitypes, with the aid of machine learning and artificial intelligence techniques. These combitypes could form the basis of workable algorithms to guide clinical decisions that make precision medicine in sepsis a reality and improve patient outcomes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 700 | 1 | |a Kox, Matthijs |e verfasserin |4 aut | |
| 700 | 1 | |a Scicluna, Brendon P |e verfasserin |4 aut | |
| 700 | 1 | |a Weigand, Markus A |e verfasserin |4 aut | |
| 700 | 1 | |a Mora, Raquel Almansa |e verfasserin |4 aut | |
| 700 | 1 | |a Flohé, Stefanie B |e verfasserin |4 aut | |
| 700 | 1 | |a Martin-Loeches, Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Lachmann, Gunnar |e verfasserin |4 aut | |
| 700 | 1 | |a Girardis, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia-Salido, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Brunkhorst, Frank M |e verfasserin |4 aut | |
| 700 | 1 | |a Bauer, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Torres, Antoni |e verfasserin |4 aut | |
| 700 | 1 | |a Cossarizza, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Monneret, Guillaume |e verfasserin |4 aut | |
| 700 | 1 | |a Cavaillon, Jean-Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Shankar-Hari, Manu |e verfasserin |4 aut | |
| 700 | 1 | |a Giamarellos-Bourboulis, Evangelos J |e verfasserin |4 aut | |
| 700 | 1 | |a Winkler, Martin Sebastian |e verfasserin |4 aut | |
| 700 | 1 | |a Skirecki, Tomasz |e verfasserin |4 aut | |
| 700 | 1 | |a Osuchowski, Marcin |e verfasserin |4 aut | |
| 700 | 1 | |a Rubio, Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Bermejo-Martin, Jesus F |e verfasserin |4 aut | |
| 700 | 1 | |a Schefold, Joerg C |e verfasserin |4 aut | |
| 700 | 1 | |a Venet, Fabienne |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Lancet. Respiratory medicine |d 2013 |g 12(2024), 4 vom: 29. Apr., Seite 305-322 |w (DE-627)NLM232005109 |x 2213-2619 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2024 |g number:4 |g day:29 |g month:04 |g pages:305-322 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/S2213-2600(23)00330-2 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2024 |e 4 |b 29 |c 04 |h 305-322 | ||