Arterial stiffness and risk of new-onset fragility fracture in Chinese men and women : The Kailuan cohort study
Copyright © 2023 Elsevier Inc. All rights reserved..
BACKGROUND: Previous studies have shown an association between increased arterial stiffness and reduced bone mineral density. However, the relationship between arterial stiffness and fragility fracture remains unclear. In this study, we explored the impact of arterial stiffness on the risk of new-onset fragility fracture.
METHODS: The study included 53,107 participants in the Kailuan Study in whom brachial-ankle pulse wave velocity (baPWV) measurements were obtained between 2010 and 2021. All participants were free of fragility fractures at baseline. A Cox proportional hazard regression model was used to estimate the hazard ratio (HR) and 95 % confidence interval (CI) for incident fragility fracture on the baseline baPWV groups: <1400 cm/s (reference), 1400 ≤ baPWV < 1800 cm/s, and ≥1800 cm/s.
RESULTS: In total, 327 incident fragility fractures were recorded during an average follow-up of 4.99 ± 3.02 years. After adjustment for potential confounders, the HR for the risk of new-onset fragility fracture was 1.66 (95 % CI 1.14-2.42) for the arterial stiffness group in comparison with the normal baPWV group. The risk of fragility fracture was higher in men (HR 1.64, 95 % CI 1.05-2.57). There was a linear association between higher baPWV and fragility fracture.
CONCLUSIONS: Arterial stiffness as measured by baPWV was associated with the risk of fragility fracture.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:180 |
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| Enthalten in: |
Bone - 180(2024) vom: 23. März, Seite 116991 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guo, Lu [VerfasserIn] |
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| Links: |
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| Themen: |
Arterial stiffness |
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| Anmerkungen: |
Date Completed 23.01.2024 Date Revised 04.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bone.2023.116991 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366324071 |
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| 245 | 1 | 0 | |a Arterial stiffness and risk of new-onset fragility fracture in Chinese men and women |b The Kailuan cohort study |
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| 500 | |a Date Revised 04.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Previous studies have shown an association between increased arterial stiffness and reduced bone mineral density. However, the relationship between arterial stiffness and fragility fracture remains unclear. In this study, we explored the impact of arterial stiffness on the risk of new-onset fragility fracture | ||
| 520 | |a METHODS: The study included 53,107 participants in the Kailuan Study in whom brachial-ankle pulse wave velocity (baPWV) measurements were obtained between 2010 and 2021. All participants were free of fragility fractures at baseline. A Cox proportional hazard regression model was used to estimate the hazard ratio (HR) and 95 % confidence interval (CI) for incident fragility fracture on the baseline baPWV groups: <1400 cm/s (reference), 1400 ≤ baPWV < 1800 cm/s, and ≥1800 cm/s | ||
| 520 | |a RESULTS: In total, 327 incident fragility fractures were recorded during an average follow-up of 4.99 ± 3.02 years. After adjustment for potential confounders, the HR for the risk of new-onset fragility fracture was 1.66 (95 % CI 1.14-2.42) for the arterial stiffness group in comparison with the normal baPWV group. The risk of fragility fracture was higher in men (HR 1.64, 95 % CI 1.05-2.57). There was a linear association between higher baPWV and fragility fracture | ||
| 520 | |a CONCLUSIONS: Arterial stiffness as measured by baPWV was associated with the risk of fragility fracture | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Arterial stiffness | |
| 650 | 4 | |a Brachial-ankle pulse wave velocity | |
| 650 | 4 | |a Cohort study | |
| 650 | 4 | |a Fragility fracture | |
| 700 | 1 | |a Zhang, Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yimeng |e verfasserin |4 aut | |
| 700 | 1 | |a Xing, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Wenqi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wenjuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Lisha |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Xiaoli |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Shuohua |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Shouling |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Faming |e verfasserin |4 aut | |
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