Head-to-head comparison of two angiography-derived fractional flow reserve techniques in patients with high-risk acute coronary syndrome : A multicenter prospective study
Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved..
BACKGROUND: FFRangio and QFR are angiography-based technologies that have been validated in patients with stable coronary artery disease. No head-to-head comparison to invasive fractional flow reserve (FFR) has been reported to date in patients with acute coronary syndromes (ACS).
METHODS: This study is a subset of a larger prospective multicenter, single-arm study that involved patients diagnosed with high-risk ACS in whom 30-70% stenosis was evaluated by FFR. FFRangio and QFR - both calculated offline by 2 different and blinded operators - were calculated and compared to FFR. The two co-primary endpoints were the comparison of the Pearson correlation coefficient between FFRangio and QFR with FFR and the comparison of their inter-observer variability.
RESULTS: Among 134 high-risk ACS screened patients, 59 patients with 84 vessels underwent FFR measurements and were included in this study. The mean FFR value was 0.82 ± 0.40 with 32 (38%) being ≤0.80. The mean FFRangio was 0.82 ± 0.20 and the mean QFR was 0.82 ± 0.30, with 27 (32%) and 25 (29%) being ≤0.80, respectively. The Pearson correlation coefficient was significantly better for FFRangio compared to QFR, with R values of 0.76 and 0.61, respectively (p = 0.01). The inter-observer agreement was also significantly better for FFRangio compared to QFR (0.86 vs 0.79, p < 0.05). FFRangio had 91% sensitivity, 100% specificity, and 96.8% accuracy, while QFR exhibited 86.4% sensitivity, 98.4% specificity, and 93.7% accuracy.
CONCLUSION: In patients with high-risk ACS, FFRangio and QFR demonstrated excellent diagnostic performance. FFRangio seems to have better correlation to invasive FFR compared to QFR but further larger validation studies are required.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:399 |
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| Enthalten in: |
International journal of cardiology - 399(2024) vom: 15. Feb., Seite 131663 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Skalidis, Ioannis [VerfasserIn] |
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| Links: |
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| Themen: |
ACS |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2023.131663 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366323865 |
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| 100 | 1 | |a Skalidis, Ioannis |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Head-to-head comparison of two angiography-derived fractional flow reserve techniques in patients with high-risk acute coronary syndrome |b A multicenter prospective study |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: FFRangio and QFR are angiography-based technologies that have been validated in patients with stable coronary artery disease. No head-to-head comparison to invasive fractional flow reserve (FFR) has been reported to date in patients with acute coronary syndromes (ACS) | ||
| 520 | |a METHODS: This study is a subset of a larger prospective multicenter, single-arm study that involved patients diagnosed with high-risk ACS in whom 30-70% stenosis was evaluated by FFR. FFRangio and QFR - both calculated offline by 2 different and blinded operators - were calculated and compared to FFR. The two co-primary endpoints were the comparison of the Pearson correlation coefficient between FFRangio and QFR with FFR and the comparison of their inter-observer variability | ||
| 520 | |a RESULTS: Among 134 high-risk ACS screened patients, 59 patients with 84 vessels underwent FFR measurements and were included in this study. The mean FFR value was 0.82 ± 0.40 with 32 (38%) being ≤0.80. The mean FFRangio was 0.82 ± 0.20 and the mean QFR was 0.82 ± 0.30, with 27 (32%) and 25 (29%) being ≤0.80, respectively. The Pearson correlation coefficient was significantly better for FFRangio compared to QFR, with R values of 0.76 and 0.61, respectively (p = 0.01). The inter-observer agreement was also significantly better for FFRangio compared to QFR (0.86 vs 0.79, p < 0.05). FFRangio had 91% sensitivity, 100% specificity, and 96.8% accuracy, while QFR exhibited 86.4% sensitivity, 98.4% specificity, and 93.7% accuracy | ||
| 520 | |a CONCLUSION: In patients with high-risk ACS, FFRangio and QFR demonstrated excellent diagnostic performance. FFRangio seems to have better correlation to invasive FFR compared to QFR but further larger validation studies are required | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ACS | |
| 650 | 4 | |a FFR | |
| 650 | 4 | |a FFRangio | |
| 650 | 4 | |a HIGH-RISK ACS | |
| 650 | 4 | |a QFR | |
| 700 | 1 | |a Noirclerc, Nathalie |e verfasserin |4 aut | |
| 700 | 1 | |a Meier, David |e verfasserin |4 aut | |
| 700 | 1 | |a Luangphiphat, Wongsakorn |e verfasserin |4 aut | |
| 700 | 1 | |a Cagnina, Aurelien |e verfasserin |4 aut | |
| 700 | 1 | |a Mauler-Wittwer, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Mahendiran, Thabo |e verfasserin |4 aut | |
| 700 | 1 | |a De Bruyne, Bernard |e verfasserin |4 aut | |
| 700 | 1 | |a Candreva, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Collet, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Sonck, Jeroen |e verfasserin |4 aut | |
| 700 | 1 | |a Muller, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Fournier, Stephane |e verfasserin |4 aut | |
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