Prevalence and type of MMR expression heterogeneity in colorectal adenocarcinoma : therapeutic implications and reporting
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
Mismatch repair (MMR) immunohistochemical (IHC) evaluation has entered pathology routine practice as the first-line screening method to identify patients with MMR deficient (MMRd)/microsatellite instability (MSI) colorectal cancer (CRC), and its misdiagnosis may significantly impact the personalization of CRC patient care. To determine the prevalence of MMR protein intratumor heterogeneity in real-world practice, we collected a series of 8282 CRCs tested for MMR proteins in the setting of Lynch syndrome universal screening. Four heterogenous cases were also investigated for tumor infiltrating lymphocytes count, MSI status, and consensus molecular subtypes by Nanostring nCounter® Platform. Overall, 1056 (12.8%) CRCs showed a MMR altered status, with 46 cases showing a heterogeneous MMR profile (0.56% of the total, and 4.36% of all MMRd cases). To conclude, the authors make some critical remarks regarding the approach to MMR heterogeneity in clinical practice and routine diagnostics.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Virchows Archiv : an international journal of pathology - (2023) vom: 23. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Grillo, Federica [VerfasserIn] |
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| Links: |
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| Themen: |
Colorectal adenocarcinoma |
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Date Revised 18.01.2024 published: Print-Electronic ErratumIn: Virchows Arch. 2024 Jan 17;:. - PMID 38231403 Citation Status Publisher |
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| doi: |
10.1007/s00428-023-03726-z |
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| PPN (Katalog-ID): |
NLM366317911 |
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| 245 | 1 | 0 | |a Prevalence and type of MMR expression heterogeneity in colorectal adenocarcinoma |b therapeutic implications and reporting |
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| 500 | |a ErratumIn: Virchows Arch. 2024 Jan 17;:. - PMID 38231403 | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a Mismatch repair (MMR) immunohistochemical (IHC) evaluation has entered pathology routine practice as the first-line screening method to identify patients with MMR deficient (MMRd)/microsatellite instability (MSI) colorectal cancer (CRC), and its misdiagnosis may significantly impact the personalization of CRC patient care. To determine the prevalence of MMR protein intratumor heterogeneity in real-world practice, we collected a series of 8282 CRCs tested for MMR proteins in the setting of Lynch syndrome universal screening. Four heterogenous cases were also investigated for tumor infiltrating lymphocytes count, MSI status, and consensus molecular subtypes by Nanostring nCounter® Platform. Overall, 1056 (12.8%) CRCs showed a MMR altered status, with 46 cases showing a heterogeneous MMR profile (0.56% of the total, and 4.36% of all MMRd cases). To conclude, the authors make some critical remarks regarding the approach to MMR heterogeneity in clinical practice and routine diagnostics | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Colorectal adenocarcinoma | |
| 650 | 4 | |a Immunohistochemistry | |
| 650 | 4 | |a Immunotherapy | |
| 650 | 4 | |a MMR; Heterogeneity | |
| 700 | 1 | |a Angerilli, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Parente, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Vanoli, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Luchini, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Sciallero, Stefania |e verfasserin |4 aut | |
| 700 | 1 | |a Puccini, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Bergamo, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Lonardi, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Valeri, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Mastracci, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Fassan, Matteo |e verfasserin |4 aut | |
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