Dietary Vitamin D Mitigates Coronavirus-Induced Lung Inflammation and Damage in Mice
The COVID-19 pandemic caused by the SARS-CoV-2 (β-CoV) betacoronavirus has posed a significant threat to global health. Despite the availability of vaccines, the virus continues to spread, and there is a need for alternative strategies to alleviate its impact. Vitamin D, a secosteroid hormone best known for its role in bone health, exhibits immunomodulatory effects in certain viral infections. Here, we have shown that bioactive vitamin D (calcitriol) limits in vitro replication of SARS-CoV-2 and murine coronaviruses MHV-3 and MHV-A59. Comparative studies involving wild-type mice intranasally infected with MHV-3, a model for studying β-CoV respiratory infections, confirmed the protective effect of vitamin D in vivo. Accordingly, mice fed a standard diet rapidly succumbed to MHV-3 infection, whereas those on a vitamin D-rich diet (10,000 IU of Vitamin D3/kg) displayed increased resistance to acute respiratory damage and systemic complications. Consistent with these findings, the vitamin D-supplemented group exhibited lower viral titers in their lungs and reduced levels of TNF, IL-6, IL-1β, and IFN-γ, alongside an enhanced type I interferon response. Altogether, our findings suggest vitamin D supplementation ameliorates β-CoV-triggered respiratory illness and systemic complications in mice, likely via modulation of the host's immune response to the virus.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Viruses - 15(2023), 12 vom: 15. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Campolina-Silva, Gabriel [VerfasserIn] |
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| Links: |
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| Themen: |
1406-16-2 |
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| Anmerkungen: |
Date Completed 25.12.2023 Date Revised 25.12.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/v15122434 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The COVID-19 pandemic caused by the SARS-CoV-2 (β-CoV) betacoronavirus has posed a significant threat to global health. Despite the availability of vaccines, the virus continues to spread, and there is a need for alternative strategies to alleviate its impact. Vitamin D, a secosteroid hormone best known for its role in bone health, exhibits immunomodulatory effects in certain viral infections. Here, we have shown that bioactive vitamin D (calcitriol) limits in vitro replication of SARS-CoV-2 and murine coronaviruses MHV-3 and MHV-A59. Comparative studies involving wild-type mice intranasally infected with MHV-3, a model for studying β-CoV respiratory infections, confirmed the protective effect of vitamin D in vivo. Accordingly, mice fed a standard diet rapidly succumbed to MHV-3 infection, whereas those on a vitamin D-rich diet (10,000 IU of Vitamin D3/kg) displayed increased resistance to acute respiratory damage and systemic complications. Consistent with these findings, the vitamin D-supplemented group exhibited lower viral titers in their lungs and reduced levels of TNF, IL-6, IL-1β, and IFN-γ, alongside an enhanced type I interferon response. Altogether, our findings suggest vitamin D supplementation ameliorates β-CoV-triggered respiratory illness and systemic complications in mice, likely via modulation of the host's immune response to the virus | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Vitamin D | |
| 650 | 4 | |a betacoronavirus | |
| 650 | 4 | |a murine coronavirus (MHV) | |
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| 700 | 1 | |a Andrade, Ana Cláudia Dos Santos Pereira |e verfasserin |4 aut | |
| 700 | 1 | |a Couto, Manoela |e verfasserin |4 aut | |
| 700 | 1 | |a Bittencourt-Silva, Paloma G |e verfasserin |4 aut | |
| 700 | 1 | |a Queiroz-Junior, Celso M |e verfasserin |4 aut | |
| 700 | 1 | |a Lacerda, Larisse de Souza B |e verfasserin |4 aut | |
| 700 | 1 | |a Chaves, Ian de Meira |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira, Leonardo C |e verfasserin |4 aut | |
| 700 | 1 | |a Marim, Fernanda Martins |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira, Cleida A |e verfasserin |4 aut | |
| 700 | 1 | |a da Silva, Glauber S F |e verfasserin |4 aut | |
| 700 | 1 | |a Teixeira, Mauro Martins |e verfasserin |4 aut | |
| 700 | 1 | |a Costa, Vivian Vasconcelos |e verfasserin |4 aut | |
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