Probiotics and Prebiotics Orally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis : An Italian Real-Life, Multicenter, Retrospective, Observational Study
The role of the skin-gut axis in atopic dermatitis (AD) remains a subject of debate, limiting non-pharmacological interventions such as probiotics and prebiotics. To improve understanding of their potential as a monotherapy for stable mild cases, we conducted a real-life, multicenter, retrospective observational study in Italy. We administered three selected bacteria (Bifidobacterium animalis subsp. lactis BS01, Lactiplantibacillus plantarum LP14, and Lacticaseibacillus rhamnosus LR05) orally to patients with mild atopic dermatitis without a placebo control group, following up for 12 weeks. Clinical assessments using the Scoring Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and Three-Item Severity (TIS) score were conducted on 144 enrolled patients (average age: 25.1 ± 17.6 years). Notably, both pruritus and AD-related lesions (erythema, edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001) after 12 weeks of exclusive probiotic and prebiotic use. These preliminary results suggest a potential link between the skin-gut microbiome and support the rationale for using specific probiotics and prebiotics in mild AD, even for maintenance, to reduce flares and dysbiosis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
|---|---|
| Enthalten in: |
Medicina (Kaunas, Lithuania) - 59(2023), 12 vom: 27. Nov. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Colombo, Delia [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 25.12.2023 Date Revised 25.12.2023 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.3390/medicina59122080 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM366288423 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM366288423 | ||
| 003 | DE-627 | ||
| 005 | 20231227141119.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231227s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/medicina59122080 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1238.xml |
| 035 | |a (DE-627)NLM366288423 | ||
| 035 | |a (NLM)38138183 | ||
| 035 | |a (PII)2080 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Colombo, Delia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Probiotics and Prebiotics Orally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis |b An Italian Real-Life, Multicenter, Retrospective, Observational Study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.12.2023 | ||
| 500 | |a Date Revised 25.12.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The role of the skin-gut axis in atopic dermatitis (AD) remains a subject of debate, limiting non-pharmacological interventions such as probiotics and prebiotics. To improve understanding of their potential as a monotherapy for stable mild cases, we conducted a real-life, multicenter, retrospective observational study in Italy. We administered three selected bacteria (Bifidobacterium animalis subsp. lactis BS01, Lactiplantibacillus plantarum LP14, and Lacticaseibacillus rhamnosus LR05) orally to patients with mild atopic dermatitis without a placebo control group, following up for 12 weeks. Clinical assessments using the Scoring Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and Three-Item Severity (TIS) score were conducted on 144 enrolled patients (average age: 25.1 ± 17.6 years). Notably, both pruritus and AD-related lesions (erythema, edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001) after 12 weeks of exclusive probiotic and prebiotic use. These preliminary results suggest a potential link between the skin-gut microbiome and support the rationale for using specific probiotics and prebiotics in mild AD, even for maintenance, to reduce flares and dysbiosis | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bifidobacterium animalis subsp. lactis BS01 | |
| 650 | 4 | |a Lacticaseibacillus rhamnosus LR05 | |
| 650 | 4 | |a Lactiplantibacillus plantarum LP14 | |
| 650 | 4 | |a atopic dermatitis | |
| 650 | 4 | |a mild atopic dermatitis | |
| 650 | 4 | |a prebiotics | |
| 650 | 4 | |a prevention | |
| 650 | 4 | |a probiotics | |
| 650 | 7 | |a Prebiotics |2 NLM | |
| 700 | 1 | |a Rigoni, Corinna |e verfasserin |4 aut | |
| 700 | 1 | |a Cantù, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Carnevali, Antonello |e verfasserin |4 aut | |
| 700 | 1 | |a Filippetti, Rossella |e verfasserin |4 aut | |
| 700 | 1 | |a Franco, Tiziana |e verfasserin |4 aut | |
| 700 | 1 | |a Grassi, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Loi, Camilla |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzotta, Annamaria |e verfasserin |4 aut | |
| 700 | 1 | |a Patroi, Ivona |e verfasserin |4 aut | |
| 700 | 1 | |a Raone, Beatrice |e verfasserin |4 aut | |
| 700 | 1 | |a Tomassini, Marco Andrea |e verfasserin |4 aut | |
| 700 | 0 | |a Young Dermatologists Italian Network |e verfasserin |4 aut | |
| 700 | 1 | |a Amoruso, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Pane, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Damiani, Giovanni |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Medicina (Kaunas, Lithuania) |d 1998 |g 59(2023), 12 vom: 27. Nov. |w (DE-627)NLM093687583 |x 1648-9144 |7 nnns |
| 773 | 1 | 8 | |g volume:59 |g year:2023 |g number:12 |g day:27 |g month:11 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/medicina59122080 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 59 |j 2023 |e 12 |b 27 |c 11 | ||