Validity and reliability of the MetabQoL 1.0 and assessment of neuropsychiatric burden in organic acidemias : Reflections from Turkey
Copyright © 2023 Elsevier Inc. All rights reserved..
OBJECTIVES: The MetabQoL 1.0 is the first disease-specific health related quality of life (HrQoL) questionnaire for patients with intoxication-type inherited metabolic disorders. Our aim was to assess the validity and reliability of the MetabQoL 1.0, and to investigate neuropsychiatric burden in our patient population.
METHODS: Data from 29 patients followed at a single center, aged between 8 and 18 years with the diagnosis of methylmalonic acidemia (MMA), propionic acidemia (PA) or isovaleric acidemia (IVA), and their parents were included. The Pediatric Quality of Life Inventory (PedsQoL) was used to evaluate the validity and reliability of MetabQoL 1.0.
RESULTS: The MetabQoL 1.0 was shown to be valid and reliable (Cronbach's alpha: 0.64-0.9). Fourteen out of the 22 patients (63.6%) formally evaluated had neurological findings. Of note, 17 out of 20 patients (85%) had a psychiatric disorder when evaluated formally by a child and adolescent psychiatrist. The median mental scores of the MetabQoL 1.0 proxy report were significantly higher than those of the self report (p = 0.023). Patients with neonatal-onset disease had higher MetabQoL 1.0 proxy physical (p = 0.008), mental (p = 0.042), total scores (p = 0.022); and self report social (p = 0.007) and total scores (p = 0.043) than those with later onset disease.
CONCLUSIONS: This study continues to prove that the MetabQoL 1.0 is an effective tool to measure what matters in intoxication-type inherited metabolic disorders. Our results highlight the importance of clinical assessment complemented by patient reported outcomes which further expands the evaluation toolbox of inherited metabolic diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:141 |
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| Enthalten in: |
Molecular genetics and metabolism - 141(2024), 1 vom: 29. Jan., Seite 108117 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ersak, Ayşe Şenol [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 22.01.2024 Date Revised 22.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ymgme.2023.108117 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM366252399 |
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| 100 | 1 | |a Ersak, Ayşe Şenol |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Validity and reliability of the MetabQoL 1.0 and assessment of neuropsychiatric burden in organic acidemias |b Reflections from Turkey |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVES: The MetabQoL 1.0 is the first disease-specific health related quality of life (HrQoL) questionnaire for patients with intoxication-type inherited metabolic disorders. Our aim was to assess the validity and reliability of the MetabQoL 1.0, and to investigate neuropsychiatric burden in our patient population | ||
| 520 | |a METHODS: Data from 29 patients followed at a single center, aged between 8 and 18 years with the diagnosis of methylmalonic acidemia (MMA), propionic acidemia (PA) or isovaleric acidemia (IVA), and their parents were included. The Pediatric Quality of Life Inventory (PedsQoL) was used to evaluate the validity and reliability of MetabQoL 1.0 | ||
| 520 | |a RESULTS: The MetabQoL 1.0 was shown to be valid and reliable (Cronbach's alpha: 0.64-0.9). Fourteen out of the 22 patients (63.6%) formally evaluated had neurological findings. Of note, 17 out of 20 patients (85%) had a psychiatric disorder when evaluated formally by a child and adolescent psychiatrist. The median mental scores of the MetabQoL 1.0 proxy report were significantly higher than those of the self report (p = 0.023). Patients with neonatal-onset disease had higher MetabQoL 1.0 proxy physical (p = 0.008), mental (p = 0.042), total scores (p = 0.022); and self report social (p = 0.007) and total scores (p = 0.043) than those with later onset disease | ||
| 520 | |a CONCLUSIONS: This study continues to prove that the MetabQoL 1.0 is an effective tool to measure what matters in intoxication-type inherited metabolic disorders. Our results highlight the importance of clinical assessment complemented by patient reported outcomes which further expands the evaluation toolbox of inherited metabolic diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a MetabQoL 1.0 | |
| 650 | 4 | |a Neurologic comorbidity | |
| 650 | 4 | |a Organic acidemias | |
| 650 | 4 | |a Pscyhiatric comorbidity | |
| 650 | 4 | |a Quality of life | |
| 700 | 1 | |a Çak, Halime Tuna |e verfasserin |4 aut | |
| 700 | 1 | |a Yıldız, Yılmaz |e verfasserin |4 aut | |
| 700 | 1 | |a Çavdar, Merve Kaşıkcı |e verfasserin |4 aut | |
| 700 | 1 | |a Tunç, Sıla |e verfasserin |4 aut | |
| 700 | 1 | |a Özer, Nagihan |e verfasserin |4 aut | |
| 700 | 1 | |a Zeltner, Nina A |e verfasserin |4 aut | |
| 700 | 1 | |a Huemer, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Tokatlı, Ayşegül |e verfasserin |4 aut | |
| 700 | 1 | |a Haliloğlu, Göknur |e verfasserin |4 aut | |
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