Omega-3 Blood Levels and Stroke Risk : A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies
BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear.
METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome.
RESULTS: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.
CONCLUSIONS: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.
| Errataetall: | |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
|---|---|
| Enthalten in: |
Stroke - 55(2024), 1 vom: 01. Jan., Seite 50-58 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
25167-62-8 |
|---|
| Anmerkungen: |
Date Completed 25.12.2023 Date Revised 18.04.2024 published: Print-Electronic ErratumIn: Stroke. 2024 Mar;55(3):e109. - PMID 38406856 Citation Status MEDLINE |
|---|
| doi: |
10.1161/STROKEAHA.123.044281 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM366249231 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM366249231 | ||
| 003 | DE-627 | ||
| 005 | 20240418232421.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231227s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1161/STROKEAHA.123.044281 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1379.xml |
| 035 | |a (DE-627)NLM366249231 | ||
| 035 | |a (NLM)38134264 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a O'Keefe, James H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Omega-3 Blood Levels and Stroke Risk |b A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.12.2023 | ||
| 500 | |a Date Revised 18.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: Stroke. 2024 Mar;55(3):e109. - PMID 38406856 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear | ||
| 520 | |a METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome | ||
| 520 | |a RESULTS: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD | ||
| 520 | |a CONCLUSIONS: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a atrial fibrillation | |
| 650 | 4 | |a cerebrovascular disease | |
| 650 | 4 | |a fish | |
| 650 | 4 | |a fish oil | |
| 650 | 4 | |a stroke | |
| 650 | 7 | |a Eicosapentaenoic Acid |2 NLM | |
| 650 | 7 | |a AAN7QOV9EA |2 NLM | |
| 650 | 7 | |a Docosahexaenoic Acids |2 NLM | |
| 650 | 7 | |a 25167-62-8 |2 NLM | |
| 650 | 7 | |a Fatty Acids, Omega-3 |2 NLM | |
| 700 | 1 | |a Tintle, Nathan L |e verfasserin |4 aut | |
| 700 | 1 | |a Harris, William S |e verfasserin |4 aut | |
| 700 | 1 | |a O'Keefe, Evan L |e verfasserin |4 aut | |
| 700 | 1 | |a Sala-Vila, Aleix |e verfasserin |4 aut | |
| 700 | 1 | |a Attia, John |e verfasserin |4 aut | |
| 700 | 1 | |a Garg, G Manohar |e verfasserin |4 aut | |
| 700 | 1 | |a Hure, Alexis |e verfasserin |4 aut | |
| 700 | 1 | |a Bork, Christian Sørensen |e verfasserin |4 aut | |
| 700 | 1 | |a Schmidt, Erik Berg |e verfasserin |4 aut | |
| 700 | 1 | |a Venø, Stine Krogh |e verfasserin |4 aut | |
| 700 | 1 | |a Chien, Kuo-Liong |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yun-Yu Amelia |e verfasserin |4 aut | |
| 700 | 1 | |a Egert, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Feldreich, Tobias Rudholm |e verfasserin |4 aut | |
| 700 | 1 | |a Ärnlöv, Johan |e verfasserin |4 aut | |
| 700 | 1 | |a Lind, Lars |e verfasserin |4 aut | |
| 700 | 1 | |a Forouhi, Nita G |e verfasserin |4 aut | |
| 700 | 1 | |a Geleijnse, Johanna M |e verfasserin |4 aut | |
| 700 | 1 | |a Pertiwi, Kamalita |e verfasserin |4 aut | |
| 700 | 1 | |a Imamura, Fumiaki |e verfasserin |4 aut | |
| 700 | 1 | |a de Mello Laaksonen, Vanessa |e verfasserin |4 aut | |
| 700 | 1 | |a Uusitupa, W Matti |e verfasserin |4 aut | |
| 700 | 1 | |a Tuomilehto, Jaakko |e verfasserin |4 aut | |
| 700 | 1 | |a Laakso, Markku |e verfasserin |4 aut | |
| 700 | 1 | |a Lankinen, Maria Anneli |e verfasserin |4 aut | |
| 700 | 1 | |a Laurin, Danielle |e verfasserin |4 aut | |
| 700 | 1 | |a Carmichael, Pierre-Hugues |e verfasserin |4 aut | |
| 700 | 1 | |a Lindsay, Joan |e verfasserin |4 aut | |
| 700 | 1 | |a Leander, Karin |e verfasserin |4 aut | |
| 700 | 1 | |a Laguzzi, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Swenson, Brenton R |e verfasserin |4 aut | |
| 700 | 1 | |a Longstreth, William T |e verfasserin |4 aut | |
| 700 | 1 | |a Manson, JoAnn E |e verfasserin |4 aut | |
| 700 | 1 | |a Mora, Samia |e verfasserin |4 aut | |
| 700 | 1 | |a Cook, Nancy R |e verfasserin |4 aut | |
| 700 | 1 | |a Marklund, Matti |e verfasserin |4 aut | |
| 700 | 1 | |a Melo van Lent, Debora |e verfasserin |4 aut | |
| 700 | 1 | |a Murphy, Rachel |e verfasserin |4 aut | |
| 700 | 1 | |a Gudnason, Vilmundur |e verfasserin |4 aut | |
| 700 | 1 | |a Ninomiya, Toshihara |e verfasserin |4 aut | |
| 700 | 1 | |a Hirakawa, Yoichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Qian, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Ardisson Korat, Andres V |e verfasserin |4 aut | |
| 700 | 1 | |a Risérus, Ulf |e verfasserin |4 aut | |
| 700 | 1 | |a Lázaro, Iolanda |e verfasserin |4 aut | |
| 700 | 1 | |a Samieri, Cecilia |e verfasserin |4 aut | |
| 700 | 1 | |a Le Goff, Mélanie |e verfasserin |4 aut | |
| 700 | 1 | |a Helmer, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Steur, Marinka |e verfasserin |4 aut | |
| 700 | 1 | |a Voortman, Trudy |e verfasserin |4 aut | |
| 700 | 1 | |a Ikram, M Kamran |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Toshiko |e verfasserin |4 aut | |
| 700 | 1 | |a Das, Jayanta K |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrucci, Luigi |e verfasserin |4 aut | |
| 700 | 1 | |a Bandinelli, Stefania |e verfasserin |4 aut | |
| 700 | 1 | |a Tsai, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Guan, Weihua |e verfasserin |4 aut | |
| 700 | 1 | |a Garg, Parveen |e verfasserin |4 aut | |
| 700 | 1 | |a Verschuren, W M Monique |e verfasserin |4 aut | |
| 700 | 1 | |a Boer, Jolanda M A |e verfasserin |4 aut | |
| 700 | 1 | |a Biokstra, Anneke |e verfasserin |4 aut | |
| 700 | 1 | |a Virtanen, Jyrki |e verfasserin |4 aut | |
| 700 | 1 | |a Wagner, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Westra, Jason |e verfasserin |4 aut | |
| 700 | 1 | |a Albuisson, Luc |e verfasserin |4 aut | |
| 700 | 1 | |a Yamagishi, Kazumasa |e verfasserin |4 aut | |
| 700 | 1 | |a Siscovick, David S |e verfasserin |4 aut | |
| 700 | 1 | |a Lemaitre, Rozenn N |e verfasserin |4 aut | |
| 700 | 1 | |a Mozaffarian, Dariush |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Stroke |d 1970 |g 55(2024), 1 vom: 01. Jan., Seite 50-58 |w (DE-627)NLM000010995 |x 1524-4628 |7 nnns |
| 773 | 1 | 8 | |g volume:55 |g year:2024 |g number:1 |g day:01 |g month:01 |g pages:50-58 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1161/STROKEAHA.123.044281 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 55 |j 2024 |e 1 |b 01 |c 01 |h 50-58 | ||