Development of a new endoscopy system to visualize bilirubin for the diagnosis of duodenogastroesophageal reflux
© 2023 Japan Gastroenterological Endoscopy Society..
OBJECTIVES: Reflux hypersensitivity (RH) is a form of refractory gastroesophageal reflux disease in which duodenogastroesophageal reflux (DGER) plays a role. This study aimed to determine the usefulness of an endoscopy system equipped with image-enhanced technology for evaluating DGER and RH.
METHODS: The image enhancement mode for detecting bilirubin and calculated values were defined as the Bil mode and Bil value, respectively. First, the visibility of the Bil mode was validated for a bilirubin solution and bile concentrations ranging from 0.01% to 100% (0.002-20 mg/dL). Second, visibility scores of the Bil mode, when applied to the porcine esophagus sprayed with a bilirubin solution, were compared to those of the blue laser imaging (BLI) and white light imaging (WLI) modes. Third, a clinical study was conducted to determine the correlations between esophageal Bil values and the number of nonacid reflux events (NNRE) during multichannel intraluminal impedance-pH monitoring as well as the utility of esophageal Bil values for the differential diagnosis of RH.
RESULTS: Bilirubin solution and bile concentrations higher than 1% were visualized in red using the Bil mode. The visibility score was significantly higher with the Bil mode than with the BLI and WLI modes for 1% to 6% bilirubin solutions (P < 0.05). The esophageal Bil value and NNRE were significantly positively correlated (P = 0.031). The area under the receiver operating characteristic curve for the differential diagnosis of RH was 0.817.
CONCLUSION: The Bil mode can detect bilirubin with high accuracy and could be used to evaluate DGER in clinical practice.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society - (2023) vom: 21. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wada, Masafumi [VerfasserIn] |
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| Links: |
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| Themen: |
Bile reflux |
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| Anmerkungen: |
Date Revised 02.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1111/den.14749 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366207199 |
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| 041 | |a eng | ||
| 100 | 1 | |a Wada, Masafumi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Development of a new endoscopy system to visualize bilirubin for the diagnosis of duodenogastroesophageal reflux |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2023 Japan Gastroenterological Endoscopy Society. | ||
| 520 | |a OBJECTIVES: Reflux hypersensitivity (RH) is a form of refractory gastroesophageal reflux disease in which duodenogastroesophageal reflux (DGER) plays a role. This study aimed to determine the usefulness of an endoscopy system equipped with image-enhanced technology for evaluating DGER and RH | ||
| 520 | |a METHODS: The image enhancement mode for detecting bilirubin and calculated values were defined as the Bil mode and Bil value, respectively. First, the visibility of the Bil mode was validated for a bilirubin solution and bile concentrations ranging from 0.01% to 100% (0.002-20 mg/dL). Second, visibility scores of the Bil mode, when applied to the porcine esophagus sprayed with a bilirubin solution, were compared to those of the blue laser imaging (BLI) and white light imaging (WLI) modes. Third, a clinical study was conducted to determine the correlations between esophageal Bil values and the number of nonacid reflux events (NNRE) during multichannel intraluminal impedance-pH monitoring as well as the utility of esophageal Bil values for the differential diagnosis of RH | ||
| 520 | |a RESULTS: Bilirubin solution and bile concentrations higher than 1% were visualized in red using the Bil mode. The visibility score was significantly higher with the Bil mode than with the BLI and WLI modes for 1% to 6% bilirubin solutions (P < 0.05). The esophageal Bil value and NNRE were significantly positively correlated (P = 0.031). The area under the receiver operating characteristic curve for the differential diagnosis of RH was 0.817 | ||
| 520 | |a CONCLUSION: The Bil mode can detect bilirubin with high accuracy and could be used to evaluate DGER in clinical practice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a bile reflux | |
| 650 | 4 | |a bilirubin | |
| 650 | 4 | |a duodenogastroesophageal reflux | |
| 650 | 4 | |a image-enhanced endoscopy | |
| 650 | 4 | |a refractory gastroesophageal reflux disease | |
| 700 | 1 | |a Minoda, Yosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Ihara, Eikichi |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuru, Hirotaka |e verfasserin |4 aut | |
| 700 | 1 | |a Hata, Yoshitaka |e verfasserin |4 aut | |
| 700 | 1 | |a Nagatomo, Shuzaburo |e verfasserin |4 aut | |
| 700 | 1 | |a Esaki, Mitsuru |e verfasserin |4 aut | |
| 700 | 1 | |a Bai, Xiaopeng |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Yoshimasa |e verfasserin |4 aut | |
| 700 | 1 | |a Chinen, Takatoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Ogino, Haruei |e verfasserin |4 aut | |
| 700 | 1 | |a Ogawa, Yoshihiro |e verfasserin |4 aut | |
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