Diagnostic performance of wide-field optical coherence tomography angiography in detecting open-angle glaucoma in high myopia
© 2023 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd..
PURPOSE: To compare the diagnostic performance of the capillary density (CD) of the central 1-6 mm and peripheral 6-12 mm annular regions in detecting open-angle glaucoma in high myopia (HM) using 15 × 12 mm wide-field swept-source optical coherence tomography angiography (WF SS-OCTA).
METHODS: The study enrolled 206 and 103 eyes with HM and highly myopic open-angle glaucoma (HM-OAG), respectively. WF SS-OCTA images centred on the fovea were obtained to analyse the changes in the CD in the 1-3 mm, 3-6 mm, 6-9 mm, and 9-12 mm annular regions. CD of the superficial capillary plexus (SCP) was measured with the built-in software. The area under the receiver operating characteristic curve (AUROC) of each region was compared.
RESULTS: The diagnostic performance of the SCP CD in the central 1-6 mm annular region (AUROC = 0.849) was better than that in the peripheral 6-12 mm annular region (AUROC = 0.756, p = 0.001). The annular AUROCs of SCP CD peaked in the 3-6 mm annular region (AUROC = 0.858) and gradually decreased with increasing diameter and were lower than the corresponding AUROCs of the ganglion cell-inner plexiform layer thickness (p < 0.05 for all comparisons). SCP CD of the inferior quadrant in the 3-6 mm annular region had the best diagnostic performance (AUROC = 0.859).
CONCLUSION: The SCP CD in the central 1-6 mm annular region exhibited better diagnostic performance for the detection of HM-OAG in HM. The assessment of more peripheral regions has no added value in detecting glaucoma in HM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:102 |
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| Enthalten in: |
Acta ophthalmologica - 102(2024), 2 vom: 01. Feb., Seite e168-e177 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Yinhang [VerfasserIn] |
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| Links: |
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| Themen: |
Capillary density |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/aos.16603 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Zhang, Yinhang |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Diagnostic performance of wide-field optical coherence tomography angiography in detecting open-angle glaucoma in high myopia |
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| 500 | |a Date Revised 14.02.2024 | ||
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| 520 | |a © 2023 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd. | ||
| 520 | |a PURPOSE: To compare the diagnostic performance of the capillary density (CD) of the central 1-6 mm and peripheral 6-12 mm annular regions in detecting open-angle glaucoma in high myopia (HM) using 15 × 12 mm wide-field swept-source optical coherence tomography angiography (WF SS-OCTA) | ||
| 520 | |a METHODS: The study enrolled 206 and 103 eyes with HM and highly myopic open-angle glaucoma (HM-OAG), respectively. WF SS-OCTA images centred on the fovea were obtained to analyse the changes in the CD in the 1-3 mm, 3-6 mm, 6-9 mm, and 9-12 mm annular regions. CD of the superficial capillary plexus (SCP) was measured with the built-in software. The area under the receiver operating characteristic curve (AUROC) of each region was compared | ||
| 520 | |a RESULTS: The diagnostic performance of the SCP CD in the central 1-6 mm annular region (AUROC = 0.849) was better than that in the peripheral 6-12 mm annular region (AUROC = 0.756, p = 0.001). The annular AUROCs of SCP CD peaked in the 3-6 mm annular region (AUROC = 0.858) and gradually decreased with increasing diameter and were lower than the corresponding AUROCs of the ganglion cell-inner plexiform layer thickness (p < 0.05 for all comparisons). SCP CD of the inferior quadrant in the 3-6 mm annular region had the best diagnostic performance (AUROC = 0.859) | ||
| 520 | |a CONCLUSION: The SCP CD in the central 1-6 mm annular region exhibited better diagnostic performance for the detection of HM-OAG in HM. The assessment of more peripheral regions has no added value in detecting glaucoma in HM | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a capillary density | |
| 650 | 4 | |a diagnostic performance | |
| 650 | 4 | |a high myopia | |
| 650 | 4 | |a open-angle glaucoma | |
| 650 | 4 | |a optical coherence tomography angiography | |
| 650 | 4 | |a wide-field | |
| 700 | 1 | |a Wang, Deming |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Fengbin |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Yunhe |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Yuying |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Meiling |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yuhong |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Jiaxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Zefeng |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiulan |e verfasserin |4 aut | |
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