Cognitive, Mental Health, Functional, and Quality of Life Outcomes 1 Year After Spontaneous Subarachnoid Hemorrhage : A Prospective Observational Study
© 2023. The Author(s)..
BACKGROUND: Patients with spontaneous subarachnoid hemorrhage (SAH) frequently encounter cognitive dysfunction and mental health issues with negative effects on health-related quality of life (HR-QoL). Here, we aimed to describe the prevalence of cognitive deficits, mental health problems, and HR-QoL impairments 1 year after SAH.
METHODS: In this prospective observational study, 177 patients with SAH admitted to our neurointensive care unit over a time span of ten years followed the invitation for an in-person 1-year follow-up, including a standardized neuropsychological test battery. Mental health issues (anxiety and depression) and HR-QoL were evaluated using questionnaires (Hospital Anxiety and Depression Scale; 36-item Short Form questionnaire). Functional outcome was assessed with the modified Rankin Scale (mRS) score.
RESULTS: Patients were 54 years of age (interquartile range 47-62 years) and presented with a median Hunt and Hess score of 2 (interquartile range 1-3) at admission. Most patients (93%) achieved good functional 1-year outcomes (mRS score 0-2). Seventy-one percent of patients had deficits in at least one cognitive domain, with memory deficits being the most prevalent (51%), followed by deficits in executive functions (36%), visuoconstruction (34%), and attention (21%). Even patients with perimesencephalic SAH (18%) or with full functional recovery (mRS score = 0, 46%) had a comparable prevalence of cognitive deficits (61% and 60%, respectively). Symptoms of depression and anxiety were reported by 16% and 33% of patients, respectively. HR-QoL was impaired in 37% (55 of 147). Patients with cognitive deficits (p = 0.001) or mental health issues (p < 0.001) more frequently reported impaired HR-QoL.
CONCLUSIONS: Most patients with SAH have cognitive deficits and mental health issues 1 year after SAH. These deficits impair patients' quality of life.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Neurocritical care - (2023) vom: 21. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rass, Verena [VerfasserIn] |
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| Links: |
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| Themen: |
Cognitive deficits |
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| Anmerkungen: |
Date Revised 22.12.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1007/s12028-023-01895-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366203657 |
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| 245 | 1 | 0 | |a Cognitive, Mental Health, Functional, and Quality of Life Outcomes 1 Year After Spontaneous Subarachnoid Hemorrhage |b A Prospective Observational Study |
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| 520 | |a © 2023. The Author(s). | ||
| 520 | |a BACKGROUND: Patients with spontaneous subarachnoid hemorrhage (SAH) frequently encounter cognitive dysfunction and mental health issues with negative effects on health-related quality of life (HR-QoL). Here, we aimed to describe the prevalence of cognitive deficits, mental health problems, and HR-QoL impairments 1 year after SAH | ||
| 520 | |a METHODS: In this prospective observational study, 177 patients with SAH admitted to our neurointensive care unit over a time span of ten years followed the invitation for an in-person 1-year follow-up, including a standardized neuropsychological test battery. Mental health issues (anxiety and depression) and HR-QoL were evaluated using questionnaires (Hospital Anxiety and Depression Scale; 36-item Short Form questionnaire). Functional outcome was assessed with the modified Rankin Scale (mRS) score | ||
| 520 | |a RESULTS: Patients were 54 years of age (interquartile range 47-62 years) and presented with a median Hunt and Hess score of 2 (interquartile range 1-3) at admission. Most patients (93%) achieved good functional 1-year outcomes (mRS score 0-2). Seventy-one percent of patients had deficits in at least one cognitive domain, with memory deficits being the most prevalent (51%), followed by deficits in executive functions (36%), visuoconstruction (34%), and attention (21%). Even patients with perimesencephalic SAH (18%) or with full functional recovery (mRS score = 0, 46%) had a comparable prevalence of cognitive deficits (61% and 60%, respectively). Symptoms of depression and anxiety were reported by 16% and 33% of patients, respectively. HR-QoL was impaired in 37% (55 of 147). Patients with cognitive deficits (p = 0.001) or mental health issues (p < 0.001) more frequently reported impaired HR-QoL | ||
| 520 | |a CONCLUSIONS: Most patients with SAH have cognitive deficits and mental health issues 1 year after SAH. These deficits impair patients' quality of life | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cognitive deficits | |
| 650 | 4 | |a Mental health outcomes | |
| 650 | 4 | |a Neuropsychological evaluation | |
| 650 | 4 | |a Quality of life | |
| 650 | 4 | |a Subarachnoid hemorrhage | |
| 700 | 1 | |a Altmann, Klaus |e verfasserin |4 aut | |
| 700 | 1 | |a Zamarian, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Lindner, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Kofler, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Gaasch, Max |e verfasserin |4 aut | |
| 700 | 1 | |a Ianosi, Bogdan-Andrei |e verfasserin |4 aut | |
| 700 | 1 | |a Putnina, Lauma |e verfasserin |4 aut | |
| 700 | 1 | |a Kindl, Philipp |e verfasserin |4 aut | |
| 700 | 1 | |a Delazer, Margarete |e verfasserin |4 aut | |
| 700 | 1 | |a Schiefecker, Alois J |e verfasserin |4 aut | |
| 700 | 1 | |a Beer, Ronny |e verfasserin |4 aut | |
| 700 | 1 | |a Pfausler, Bettina |e verfasserin |4 aut | |
| 700 | 1 | |a Helbok, Raimund |e verfasserin |4 aut | |
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