Time course of body composition changes in transgender adolescents during puberty suppression and sex hormone treatment
© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society..
CONTEXT: Transgender adolescents can undergo puberty suppression (PS) and subsequent gender-affirming hormone therapy (GAHT) but little information is available on the expected rate of physical changes.
OBJECTIVE: To investigate the time course of body composition changes during PS and GAHT.
DESIGN: Retrospective cohort study.
SETTING: Gender identity clinic.
PARTICIPANTS: 380 trans boys and 168 trans girls treated with PS prior to GAHT.
MAIN OUTCOME MEASURES: Total lean- and fat mass Z-scores using birth-assigned sex as reference determined using dual energy X-ray absorptiometry.
RESULTS: In trans boys, lean mass Z-scores decreased (-0.32, 95%CI -0.41; -0.23) and fat mass Z-scores increased (0.31, 95%CI 0.21; 0.41) in the first year of PS and remained stable thereafter. Only during the first year of testosterone, lean mass Z-scores increased (0.92, 95%CI 0.81; 1.04) and fat mass Z-scores decreased (-0.43, 95%CI -0.57; -0.29). In trans girls, both lean and fat mass Z-scores gradually changed over three years of PS (respectively -1.13, 95%CI -1.29; -0.98 and 1.06, 95%CI 0.90; 1.23). Only in the first year of GAHT, lean mass Z-scores decreased (-0.19, 95%CI -0.36; -0.03) while fat mass Z-scores remained unchanged after three years (-0.02, 95%CI -0.20; 0.16).
CONCLUSIONS: Compared to peers, trans girls experienced ongoing lean mass decrease and fat mass increase during 3 years of PS while in trans boys smaller changes were observed that stabilized after one year. A large increase in lean mass Z-scores occurred only during the first year of testosterone treatment. In trans girls, body composition changed only slightly during GAHT. This information can improve counseling about treatment effects.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
The Journal of clinical endocrinology and metabolism - (2023) vom: 21. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Boogers, Lidewij Sophia [VerfasserIn] |
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| Links: |
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| Themen: |
Adolescents |
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| Anmerkungen: |
Date Revised 21.12.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1210/clinem/dgad750 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM366187201 |
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| 100 | 1 | |a Boogers, Lidewij Sophia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Time course of body composition changes in transgender adolescents during puberty suppression and sex hormone treatment |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. | ||
| 520 | |a CONTEXT: Transgender adolescents can undergo puberty suppression (PS) and subsequent gender-affirming hormone therapy (GAHT) but little information is available on the expected rate of physical changes | ||
| 520 | |a OBJECTIVE: To investigate the time course of body composition changes during PS and GAHT | ||
| 520 | |a DESIGN: Retrospective cohort study | ||
| 520 | |a SETTING: Gender identity clinic | ||
| 520 | |a PARTICIPANTS: 380 trans boys and 168 trans girls treated with PS prior to GAHT | ||
| 520 | |a MAIN OUTCOME MEASURES: Total lean- and fat mass Z-scores using birth-assigned sex as reference determined using dual energy X-ray absorptiometry | ||
| 520 | |a RESULTS: In trans boys, lean mass Z-scores decreased (-0.32, 95%CI -0.41; -0.23) and fat mass Z-scores increased (0.31, 95%CI 0.21; 0.41) in the first year of PS and remained stable thereafter. Only during the first year of testosterone, lean mass Z-scores increased (0.92, 95%CI 0.81; 1.04) and fat mass Z-scores decreased (-0.43, 95%CI -0.57; -0.29). In trans girls, both lean and fat mass Z-scores gradually changed over three years of PS (respectively -1.13, 95%CI -1.29; -0.98 and 1.06, 95%CI 0.90; 1.23). Only in the first year of GAHT, lean mass Z-scores decreased (-0.19, 95%CI -0.36; -0.03) while fat mass Z-scores remained unchanged after three years (-0.02, 95%CI -0.20; 0.16) | ||
| 520 | |a CONCLUSIONS: Compared to peers, trans girls experienced ongoing lean mass decrease and fat mass increase during 3 years of PS while in trans boys smaller changes were observed that stabilized after one year. A large increase in lean mass Z-scores occurred only during the first year of testosterone treatment. In trans girls, body composition changed only slightly during GAHT. This information can improve counseling about treatment effects | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Estradiol | |
| 650 | 4 | |a GnRHa | |
| 650 | 4 | |a Testosterone | |
| 650 | 4 | |a adolescents | |
| 650 | 4 | |a body composition | |
| 650 | 4 | |a transgender | |
| 700 | 1 | |a Reijtenbagh, Sterre Johanna Petronella |e verfasserin |4 aut | |
| 700 | 1 | |a Wiepjes, Chantal Maria |e verfasserin |4 aut | |
| 700 | 1 | |a van Trotsenburg, Adrianus Sarinus Paulus |e verfasserin |4 aut | |
| 700 | 1 | |a den Heijer, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Hannema, Sabine Elisabeth |e verfasserin |4 aut | |
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